|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nat Biotechnol:将人星形胶质细胞重编程为多巴胺能神经元,有助治疗帕金森病显示文摘帕金森病是一种主要影响运动系统的神经退行性疾病。它的特征在于大脑中的多巴胺能神经元(dopaminergic neuron)渐进性丧失。尽管当前的疗法旨在补充多巴胺水平,但是没有一种疗法能够恢复这些丢失的细胞。如今。在一项新的研究中,来自瑞典、奥地利、西班牙和美国的研究人员开发出一种方法:将神经胶质细胞(glialcell)转化为活性的多巴胺能神经元,并且所产生的多巴胺能神经元能够部分恢复帕金森病模式小鼠的运动功能。这项概念验证研究可能为开发出一种治疗这种疾病的新方法铺平道路。 | Pia Rivetti di Val Cervo, Elisa Martín-Montañez, Enrique M Toledo, Gioele La Manno, Sara Padrell Sánchez, Sten Linnarsson Ernest Arenas Roman A Romanov, Christian Pifl Tibor Harkany Roman A Romanov, Giada Spigolon, Débora Masini, Michael Feyder, Tibor Harkany Gilberto Fisone Elisa Martín-Montañez Yi-Han Ng Marius Wernig | 2017 | 现代生物医学进展2017，17，17： | 11 |
| 2 | Deregulation,Privatization,and Competition:Transmission Planning under Uncertainty显示文摘 | De la Torre T Feltes J W Roman T G S | 1999 | IEEE Trans on Power Systems1999，14，2： | 1 |
| 3 | Disparity for the minor histocompatibility antigen HA-1 is associated with an increased risk of acute graft-versus-host disease(GvHD)but it does not affect chronic GvHD incidence,disease-free survival or overall survival after allogeneic human leucocyte antigen-identical sibling donor transplantation显示文摘 | Arostegui JI Balas A Torres A Caballero D Carreras E Brunet S Jimenez A Mataix R Serrano D Vallejo C Sanz G Solano C Rodriguez-Luaces M Marin J Baro J Sanz C Roman J Gonzalez M Martorell J Sierra J Martin C de la Camara R Granena A | 2001 | Br J Haematol2001，114，4： | 1 |
| 4 | Synthesis of terpineol from α-pinene by homogeneous acid catalysis显示文摘 | ROMAN AGUIRRE M DE LA TORRE SAENZ L FLORE W A | 2005 | Catalysis Today2005，，： | 1 |
| 5 | Synthesis of terpineol fromα-pinene by homo-geneous acid catalysis显示文摘 | Roman Aguirre M De la Torre Saenz L Wilber AntunezFlore | 2005 | Catalysis Today2005，，107108： | 1 |
| 6 | Specific therapy in water,electrolyte and blood-volume replacement during pediatric surgery显示文摘 | Furman EB Roman DG Lemmer LA | 1975 | Anesthesiology1975，42，2： | 1 |
| 7 | Cerebral Palsy显示文摘 | Roman LA Smith BP Shilt | 2004 | Lancet (S1474-- 4422)2004，363，： | 1 |
| 8 | Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients显示文摘 | Wang TL Diaz LA Jr Romans K | 2004 | Proc Natl Acad Sci U S A2004，101，9： | 1 |
| 9 | Videokeratoscopes for dioptric power measurement during surgery显示文摘 | Carvalho LA Stefani M Roman AC | 2002 | J Cataract Refract Surg2002，28，11： | 1 |
| 10 | Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5 -fluorouracil in metastatic colorectal cancer patients 显示文摘 | Wang TL Diaz LA Romans K | 2004 | Proc Nat! Acad Sci USA2004，101，9： | 1 |
| 11 | Synthesis of terpineol from a-pi- nene by homogeneous acid catalysis显示文摘 | Roman Aguirre M De la Torre Saenz L Wilber An- tunez Flore | 2005 | Catalysis Today2005，，： | 1 |
| 12 | Disseminating tumor cells and their interactions with leukocytes visualized in the brain 显示文摘 | Lampson LA Wen P Roman VA | 1992 | Cancer Res1992，52，4： | 1 |
| 13 | Transforming growth factor betal expression and activation is increased in the alcoholic rat lung显示文摘 | Bechara RI Brown LA Roman J | 2004 | AmJRespirCritCare Med2004，170，2： | 1 |
| 14 | Under regulation privatization and competition:transmission planning under uncertainty显示文摘 | Teofilo De la Tone Feltes J W Tomas Gomez San Roman | 1999 | IEEE Transactions on Power Systems1999，14，2： | 1 |
| 15 | 地中海膳食可降低24h动态血压、空腹血糖及血脂:1年随机临床试验显示文摘地中海膳食(MedDiets)添加橄榄油或坚果,较对照组低脂膳食可减少心血管事件,特别是脑卒中,但其心血管保护机制尚不清楚。研究人员进行随机、平行设计、对照试验研究,评估长达1年添加橄榄油或坚果的地中海膳食对24h动态血压、血糖和血脂的影响。膳食时间随意, | Doménech M Roman P Lapetra J García de la Corte FJ Sala-Vila A de la Torre R Corella D Salas-Salvadó J Ruiz-Gutiérrez V Lamuela-Raventós RM Toledo E Estruch R Coca A Ros E 赵狄 | 2014 | 中华高血压杂志2014，22，7： | 1 |
| 16 | Synthesis of terpineol from a-pinene by homogeneous acid catalysis显示文摘 | Roman Aguirre M De la Torte Saenz L Wilber Antunez Flore | 2005 | Catalysis Today2005，，： | 1 |
| 17 | Prospective application of a bleeding and ischemic risks-adjusted antithrombotic protocol in elderly patients revascularized with everolimus-eluting stents:EPIC05-Sierra75 study显示文摘OBJECTIVES Elderly patients show a higher incidence of ischemic and bleeding events after percutaneous transluminal coron-ary intervention(PCI).We sought to investigate outcomes in elderly patients treated with antithrombotic strategy guided by bleeding and ischemic risks after revascularization with last generation everolimus-eluting stent(EES).METHODS Prospective multicenter registry including patients over 75 years revascularized with EES and antithrombotic ther-apy guided by clinical presentation,PCI complexity and PRECISE DAPT score.Co-primary safety endpoints were:(1)composite of cardiac death,myocardial infarction and stent thrombosis and;(2)bleeding(BARC 2-5).Primary efficacy endpoint was target lesion revascularization.A matched group of patients revascularized with current drug-eluting stents and no such tailored antith-rombotic therapy was used as control.RESULTS Finally,1064 patients were included in SIERRA-75 cohort,80.8±4.2 years,36.6%women,71%acute coronary syn-dromes(ACS)and 53.6%complex PCI.Co-primary safety endpoint of major adverse cardiovascular events was met in 6.2%,co-primary safety endpoint of bleeding in 7.8%and primary efficacy endpoint of TKLR in 1.5%.The multivariable adjusted model showed no significant association of the prescribed short/long dual antiplatelet therapy(DAPT)durations with any endpoint suggesting a well tailored therapy.No stent thrombosis reported in the subgroup with 1-3 months DAPT duration.As compared to control group,bleeding BARC 2-5 was significantly lower in SIERRA-75 group(7.4%vs.10.2%,P=0.04)as well as the net safety-efficacy endpoint(14.3%vs.18.5%,P=0.02).CONCLUSIONS In elderly population,the application of this risks-adjusted antithrombotic protocol after revascularization with last generation EES seems to be associated with an improved prognosis in terms of ischemic and bleeding outcomes. | Jose M de la Torre Hernandez Ramon Lopez Palop Jesus M Jimenez Mazuecos Pilar Carrillo Sáez Alejandro Gutierez-Barrios Eduardo Pinar Belen Cid Luis Fernandez Tamara Garcia Camarero Cristóbal Urbano-Carrillo Juan F Oteo Dominguez Victor A Jimenez Diaz Antonio EGomez Menchero Eladio Galindo Fernández Juan GCórdoba Soriano Raymundo Ocaranza Eduardo ArroyoÚcar Koldobika Garcia San Roman Silvio Leal Ginés Martínez Cáceres Jose A Linares Vicente Georgina Fuertes Ferre Xavier Carrillo Juan CRama Merchán Catia Costa Juan Sanchis Renato Fernandes Alberto Rodrigues Jose M Vegas Valle Hélder Pereira Armando Perez de Prado | 2022 | Journal of Geriatric Cardiology2022，19，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员