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| 1 | Bloodcells cholinester- ase activity in early stage alzheimer, s Disease and vascular de- mentia显示文摘 | Rommy V Bernhard I Rodrigo A | 2005 | Dement Geriatr Cogn Disord2005，19，4： | 1 |
| 2 | Mothers inter- actions with normal and conduct disordered boys: who affects whom? 显示文摘 | Anderson KE Lytton H Rommy DM | 1986 | Developmental Psychology1986，22，： | 1 |
| 3 | High - thermal - conductivity, meso - phase - pitch - derived carbon foams: effect of precursor on structure and properties 显示文摘 | JAMES KLETT ROMMIE HARDY ERNIE ROMINE | 2000 | Carbon2000，38，： | 1 |
| 4 | High-thermal- conductivity, mesophase-pitch-derived carbon foams : Effect of precursor on structure and properties显示文摘 | James Klett Rommie Hardy Ernie Romine | 2000 | Carbon2000，38，7： | 1 |
| 5 | High-thermal-conductivity, mesophase-pitch-derived carbon foams : effect of precursor on structure and properties 显示文摘 | James Klett Rommie Hardy Ernie Romine | 2000 | Carbon2000，38，7： | 1 |
| 6 | Implementing ERP显示文摘 | S Glover D Prawitt and M Rommy | 1999 | The Internal Auditor1999，56，1： | 1 |
| 7 | Highthermal-conductivity, mesophase-pitch-derived carbon foa-ms; Effect of precursor on structure and properties显示文摘 | James Klett Rommie Hardy Ernie Romine | 2000 | Carbon2000，38，： | 1 |
| 8 | Mothers interactions with normal and conduct disordered boys : who affects whom? 显示文摘 | Anderson ICE Lytton H Rommy DM | 1986 | Developmental Psychology1986，22，： | 1 |
| 9 | s Disease and vascular dementia显示文摘 | Rommy V Bernhard I Rodrigo A Diego M Blood- cells cholinesterase activity in early stage alzheimer | 2005 | Dement Geriatr Cogn Disord2005，19，4： | 1 |
| 10 | High-thermal-conductivity, mesophase-pitch-derived carbon foams: effect of precursor on structure and properties显示文摘 | JAMES KLETT ROMMIE HARDY ERNIE ROMINE CLAUDIA WALLS TIM BURCHELL | 2000 | Carbon2000，，38： | 1 |
| 11 | Blood cells cholinesterase activity in early stage alzheimer' s Disease and vascular dementia 显示文摘 | Rommy yon Bemhardi Rodrigo Alarcon Diego Mezzano | 2005 | Dement Geriatr Cogn Disord2005，19，4： | 1 |
| 12 | An improved relaxed complex scheme for receptor flexibility in computer-aided drug design显示文摘 | Rommie E. Amaro Riccardo Baron J. Andrew McCammon | 2008 | Journal of Computer - Aided Molecular Design2008，，9： | 1 |
| 13 | High-thermal-conductivity, mesophase-pitch-derived carbon foams: effect of precursor on structure and properties显示文摘 | James Klett Rommie Hardy Ernie Romine Claudia Walls Tim Burchell | 2000 | Carbon2000，，7： | 1 |
| 14 | Highthermal-conductivity mesophase-pitch-derived carbon foams,effect of precursor on structure and properties显示文摘 | James Klett Rommie Hardy Ernie Romine | | 0，，07： | 1 |
| 15 | Ways of Increasing Synergy in Automated Factory Design and Commissioning Teamwork显示文摘 | Rommi Kaeillo Martin Eerme Vello Reedik | 2013 | 材料科学与工程(中英文B版)2013，3，9： | 0 |
| 16 | On Synergy Deployment in Engineering Design显示文摘 | Tiit Hindreus Frid Kaljas Rommi Kaillo Andres Martin Toivo Taihemaa Vello Reedik | 2012 | 材料科学与工程(中英文B版)2012，2，6： | 0 |
| 17 | DelEnsembleElec:Computing Ensemble-Averaged Electrostatics Using DelPhi显示文摘A new VMD plugin that interfaces with DelPhi to provide ensemble-averaged electrostatic calculations using the Poisson-Boltzmann equation is presented.The general theory and context of this approach are discussed,and examples of the plugin interface and calculations are presented.This new tool is applied to systems of current biological interest,obtaining the ensemble-averaged electrostatic properties of the two major influenza virus glycoproteins,hemagglutinin and neuraminidase,from explicitly solvated all-atom molecular dynamics trajectories.The differences between the ensemble-averaged electrostatics and those obtained from a single structure are examined in detail for these examples,revealing how the plugin can be a powerful tool in facilitating the modeling of electrostatic interactions in biological systems. | Lane W.Votapka Luke Czapla Maxim Zhenirovskyy Rommie E.Amaro | 2013 | Communications in Computational Physics2013，13，1： | 0 |
| 18 | Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue显示文摘Market drugs,suchas Foodand Drug Administration(FDA)or European Medicines Agency(EMA)-approved drugs for specific indications provide opportunities for repurposing for newer therapeutics.This potentially saves resources invested in clinical trials that verify drug safety and tolerance in humans prior to alternative indication approval.Protein arginine methyltransferase 5(PRMT5)overexpression has been linked to promoting the tumor phenotype in several cancers,including pancreatic ductal adenocarcinoma(PDAC),colorectal cancer(CRC),and breast cancer(BC),making PRMT5 an important target for cancer therapy.Previously,we showed that PRMT5-mediated methylation of the nuclear factor(NF)-kB,partially contributes to its constitutive activation observed in cancers.In this study,we utilized an AlphaLiSA-based high-throughput screening method adapted in our lab,and identified one FDA-approved drug,Candesartan cilexetil(Can,used in hypertension treatment)and one EMA-approved drug,Cloperastine hydrochloride(Clo,used in cough treatment)that had significant PRMT5-inhibitory activity,and their anti-tumor properties were validated using cancer phenotypic assays in vitro.Furthermore,PRMT5 selective inhibition of methyltransferase activity was confirmed by reduction of both NF-kB methylation and its subsequent activation upon drug treatment.Using in silico prediction,we identified critical residues on PRMT5 targeted by these drugs that may interfere with its enzymatic activity.Finally,Clo and Can treatment have exhibited marked reduction in tumor growth in vivo.Overall,we provide basis for pursuing repurposing Clo and Can as anti-PRMT5 cancer therapies.Our study offers potential safe and fast repurposing of previously unknown PRMT5 inhibitors into clinical practice. | Lakshmi Prabhu Matthew Martin Lan Chen Ozlem Demir Jiamin Jin Xiumei Huang Aishat Motolani Mengyao Sun Guanglong Jiang Harikrishna Nakshatri Melissa L.Fishel Steven Sun Ahmad Safa Rommie E.Amaro Mark R.Kelley Yunlong Liu Zhong-Yin Zhang Tao Lu | 2023 | Genes & Diseases2023，10，1： | 0 |
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