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| 1 | Systematic review: The placebo effect of psychological interventions in the treatment of irritable bowel syndrome显示文摘AIM To determine the placebo response rate associated with different types of placebo interventions used in psychological intervention studies for irritable bowel syndrome. METHODS Randomized controlled trials comparing psychological interventions(stress management/relaxation therapy(cognitive) behavioral therapy, short-term psychodynamic therapy, and hypnotherapy) for the treatment of adult patients with irritable bowel syndrome(IBS) diagnosed with the Manning or Rome criteria with an adequate placebo control treatment and reporting data on IBS symptom severity were identified by searching Pub Med, Embase, the Cochrane Library, CINAHL and Psyc INFO databases. Full-text articles that were written in English and published between 1966 and February 2016 in peer-reviewed journals were selected for the present review. Placebo interventions were considered to be adequate if the number of sessions and the amount of time spent with the therapist were the same as in the active treatment. The placebo response rate(PRR) was computed for IBS symptom severity(primary outcome measure) as well as for anxiety, depression and quality of life(secondary outcome measures). RESULTS Six studies, with a total of 555 patients met the inclusion criteria. Four studies used an educational intervention, whereas two studies used a form of supportive therapy as the placebo intervention. The PRR for IBS symptom severity ranged from 25% to 59%, with a pooled mean of 41.4%. The relative PRR for the secondary outcome measures ranged from 0% to 267% for anxiety, 6% to 52% for depression 20% to 125% for quality of life. The PRR associated with pharmacological treatments, treatment with dietary bran and complementary medicine ranged from 37.5% to 47%. Contrary to our expectations, the PRR in studies on psychological interventions was comparable to that in studies on pharmacological, dietary and alternative medical interventions.CONCLUSION The PRR is probably determined to a larger extent by patient-related factors, such as expectations and desire for the treatment to be effective, than the content of the placebo intervention. | Carla E Flik Laura Bakker Wijnand Laan Yanda R van Rood André JPM Smout Niek J de Wit | 2017 | World Journal of Gastroenterology2017，23，12： | 7 |
| 2 | Mercury adsorption properties of sulfur-impregnated adsorbents 显示文摘 | Hsi H Rood M J Abadi M R | 2002 | Journal of Environmental Engineering2002，128，11： | 1 |
| 3 | The 5'non-translated region of Varroa destructor virus 1 ( genus Iflavirus ) : structure prediction and IRES activity in Lymantria dispar cells 显示文摘 | Ongus R Roode C Pleij A | 2006 | J Gen Virol2006，87，11： | 1 |
| 4 | Perspectives for the industrial enzymatic production of glycosides显示文摘 | DE ROODE B M FRANSSEN M C R PADT A | 2003 | Bioteelmol Prog2003，19，5： | 1 |
| 5 | Prevalence study of an-tibody to ratborne pathogens and other agents among patients u-sing a free clinic in downtown Los Angeles显示文摘 | Smith HM Reporter R Rood MP | 2002 | J Infect Dis2002，186，11： | 1 |
| 6 | Auditory Steadystate responses for children with servere to profound hearing loss 显示文摘 | Swanepoel D Hugo R Roode R | 2004 | Arch Otolaryngol headneck surg2004，130，： | 1 |
| 7 | Stratosphere-troposphere exchange 显示文摘 | Holton J R Haynes P H MeIntyre M E Douglass A R Rood R B PfisterL | 1995 | Rev Geophys1995，33，4： | 1 |
| 8 | Childhood- onset systemic lupus erythematosus: Clinical presentation and prognosis in 31 patients 显示文摘 | Rood MJ ten Cate R van Suijlekom- Smit LW | 1999 | Scand J Rheumatol1999，28，4： | 1 |
| 9 | Multidimensional flux-form semi-Lagrangian transport schemes 显示文摘 | Lin S J Rood R B | 1996 | Mon Wea Rev1996，124，： | 1 |
| 10 | Synopticscale mass exchange from the troposphere to the stratosphere显示文摘 | Rood R B Douglass A R Cerniglia M C | 1997 | Journal of Geophysical Research1997，102，23： | 1 |
| 11 | Atmospheric sulfurcycle simulated in the global model GOCART : Modeldescription and global properties显示文摘 | CHIN M ROOD R B LIN S J | 2000 | Journal of Geophysi-cal Research: Atmospheres (1984-2012)2000，105，24： | 1 |
| 12 | Auditory steadystate responses for children with severe to profound hearing loss显示文摘 | Swanepoel D Hugo R Roode R | 2004 | Arch Otolaryngol Head Neck Surg2004，130，5： | 1 |
| 13 | Regulation of the rabbit ileal brush-border Na^+/H^+ exchanger by an ATP-requiring Ca^2+/calmodulin-mediated process 显示文摘 | Rood R P Emmer E Wesolek J | 1988 | The Journal of Clinical Investigation1988，82，： | 1 |
| 14 | Hepatitis E virus in rats, Los Angeles, California, USA 显示文摘 | PURCELL R H ENGLE R E ROOD M P | 2011 | Emerg Infect Dis2011，17，12： | 1 |
| 15 | The occurrence of antibiotic resistance in Clostridium perfringens from pigs 显示文摘 | Rood J L Buddle J R Wales A J | 1985 | Aust Vet J1985，62，8： | 1 |
| 16 | Effect of tolerance to noninherited maternal antigens on the occurrence of graft-veersus-host disease after bone marrow transplantation from a parent or an HLA-haploidentical sibling显示文摘 | VAN ROOD J J LOBERIZA F R J R ZHANG M J | 2002 | Blood2002，99，： | 1 |
| 17 | Scavenger chemokine(CXC motif)receptor7(CXCR7)is a direct target gene of HIC1(hypermethylated in cancer1)显示文摘 | Van Rechem C Rood B R Touka M | 2009 | Journal of Biological Chemistry2009，284，20： | 1 |
| 18 | The 5'non-translated region of Varroa destructor virus 1(genus Iflavirus):structure prediction and IRES activity in Lymantria dispar cells显示文摘 | Ongus J R Roode E C Pleij C W A | 2006 | J Gen Virol2006，87，11： | 1 |
| 19 | Fetal development of the auditory tube and paratubal musculature显示文摘 | SWARTS J D ROOD S R DOYLE W J | 1986 | Cleft Palate J1986，23，： | 1 |
| 20 | Effect of toleranc to noninheritde maternal antigens on the occurrence of graf rsus-hast diease after bone marrow transplantation from a parent or all HLA-haploidentical sibling显示文摘 | VAN ROOD J J LOBERIZAFR J R ZHANG M J | 2002 | Blood2002，99，： | 1 |
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