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| 1 | Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis显示文摘AIM: To assess the relationship between vitamin D re-ceptor (VDR) gene polymorphisms and the presence of hepatocellular carcinoma (HCC). METHODS: Two-hundred forty patients who underwent liver transplantation were studied. The etiologies of liver disease were hepatitis C (100 patients), hepatitis B (37) and alcoholic liver disease (103). A group of 236 healthy subjects served as controls. HCC in the explanted liver was detected in 80 patients. The following single nucle-otide gene polymorphisms of the VDR were investigatedby polymerase chain reaction and restriction fragment length polymorphism: FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) (BAT). RESULTS: The frequencies of genotypes in patients without and with HCC were for FokI F/F = 69, F/f = 73, f/f = 18 and F/F = 36, F/f = 36, f/f = 8; BsmI b/b = 45, B/b = 87, B/B = 28 and b/b = 33, B/b = 35, B/B = 12; for ApaI A/A = 53, A/a = 85, a/a = 22 and A/A = 27, A/a = 38, a/a = 15; for TaqI T/T = 44, T/t = 88, t/t = 28 and T/T = 32, T/t = 38, t/t = 10. Carriage of the b/b genotype of BsmI and the T/T genotype of TaqI was signif icantly associated with HCC (45/160 vs 33/80, P < 0.05 and 44/160 vs 32/80, P < 0.05, respectively). The absence of the A-T-C protective allele of BAT was signif i-cantly associated with the presence of HCC (46/80 vs 68/160, P < 0.05). A strong association was observed between carriage of the BAT A-T-C and G-T-T haplotypes and HCC only in alcoholic liver disease (7/46 vs 12/36 vs 11/21, P < 0.002, respectively).CONCLUSION: VDR genetic polymorphisms are sig-nificantly associated with the occurrence of HCC in patients with liver cirrhosis. This relationship is more specific for patients with an alcoholic etiology. | Edmondo Falleti Davide Bitetto Carlo Fabris Annarosa Cussigh Elisabetta Fontanini Ezio Fornasiere Elisa Fumolo Sara Bignulin Sara Cmet Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: Role in the course of chronic viral hepatitis and the development of HCC显示文摘 | Carlo Fabris Edmondo Falleti Annarosa Cussigh Davide Bitetto Elisabetta Fontanini Sara Bignulin Sara Cmet Ezio Fornasiere Elisa Fumolo Stefano Fangazio Andrea Cerutti Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | Journal of Hepatology2010，，4： | 1 |
| 3 | Excess body weight, liver steatosis, and early fibrosis progression due to hepatitis C recurrence after liver transplantation显示文摘AIM: To investigate how weight gain after OLT affects the speed of fibrosis progression (SFP) during recurrent hepatitis C virus (HCV) infection of the graft.METHODS: Ninety consecutive patients (63 males,median age 53 years; 55 with HCV-related liver disease),transplanted at a single institution, were studied. All were followed for at least 2 years after OLT and had at least one follow-up graft biopsy, performed not earlier than 1 year after the transplant operation. For each biopsy, a single,experienced pathologist gave an estimate of both the staging according to Ishak and the degree of hepatic steatosis.The SFP was quantified in fibrosis units/month (FU/mo).The lipid metabolism status of patients was summarized by the plasma triglycerides/cholesterol (T/C) ratio. Body mass index (BMI) was measured before OLT, and 1 and 2 years after it.RESULTS: In the HCV positive group, the highest SFP was observed in the first post-OLT year. At that time point,a SFP ≤0.100 FU/mo was observed more frequently among recipients who had received their graft from a young donor and had a pre-transplant BMI value >26.0 kg/m2. At completion of the first post-transplant year, a BMI value >26.5 kg/m2 was associated with a T/C ratio ≤1. The proportion of patients with SFP >0.100 FU/mo descended in the following order: female recipients with a high T/C ratio, male recipients with high T/C ratio, and recipients of either gender with low T/C ratio. Hepatic steatosis was observed more frequently in recipients who, in the first post-transplant year, had increased their BMI ≥1.5 kg/m2 in comparison to the pre-transplant value. Hepatic steatosis was inversely associated with the staging score.CONCLUSION: Among HCV positive recipients, excessweight gain post-OLT does not represent a factor favoring early liver fibrosis development and might even be protective against it. | Pierluigi Toniutto Carlo Fabris Claudio Avellini Rosalba Minisini Davide Bitetto Elisabetta Rossi Carlo Smirne Mario Pirisi | 2005 | World Journal of Gastroenterology2005，11，38： | 1 |
| 4 | IL-28B rs12979860 C/T allele distribution in patients with liver cirrhosis: Role in the course of chronic viral hepatitis and the development of HCC显示文摘 | Carlo Fabris Edmondo Falleti Annarosa Cussigh Davide Bitetto Elisabetta Fontanini Sara Bignulin Sara Cmet Ezio Fornasiere Elisa Fumolo Stefano Fangazio Andrea Cerutti Rosalba Minisini Mario Pirisi Pierluigi Toniutto | 2010 | Journal of Hepatology2010，，4： | 1 |
| 5 | TGF-β1 genotypes in cirrhosis: Relationship with the occurrence of liver cancer显示文摘 | Edmondo Falleti Carlo Fabris Pierluigi Toniutto Elisabetta Fontanini Annarosa Cussigh Davide Bitetto Ezio Fornasiere Claudio Avellini Rosalba Minisini Mario Pirisi | 2008 | Cytokine2008，，： | 1 |
| 6 | Genetic polymorphisms of interleukin-6 modulate fibrosis progression in mild chronic hepatitis C显示文摘 | Edmondo Falleti Carlo Fabris Carmen Vandelli Cosimo Colletta Annarosa Cussigh Carlo Smirne Elisabetta Fontanini Sara Cmet Rosalba Minisini Davide Bitetto Pierluigi Toniutto Mario Pirisi | 2010 | Human Immunology2010，，10： | 1 |
| 7 | Finding the seed of recurrence:Hepatocellular carcinoma circulating tumor cells and their potential to drive the surgical treatment显示文摘The treatment for hepatocellular carcinoma(HCC)relies on liver resection,which is,however,burdened by a high rate of recurrence after surgery,up to 60%at 5 years.No pre-operative tools are currently available to assess the recurrence risk tailored to every single patient.Recently liquid biopsy has shown interesting results in diagnosis,prognosis and treatment allocation strategies in other types of cancers,since its ability to identify circulating tumor cells(CTCs)derived from the primary tumor.Those cells were advocated to be responsible for the majority of cases of recurrence and cancer-related deaths for HCC.In fact,after being modified by the epithelial-mesenchymal transition,CTCs circulate as“seeds”in peripheral blood,then reach the target organ as dormant cells which could be subsequently“awakened”and activated,and then initiate metastasis.Their presence may justify the disagreement registered in terms of efficacy of anatomic vs non-anatomic resections,particularly in the case of microvascular invasion,which has been recently pointed as a histological sign of the spread of those cells.Thus,their presence,also in the early stages,may justify the recurrence event also in the contest of liver transplant.Understanding the mechanism behind the tumor progression may allow improving the treatment selection according to the biological patient-based characteristics.Moreover,it may drive the development of novel biological tailored tests which could address a specific patient to neoadjuvant or adjuvant strategies,and in perspective,it could also become a new method to allocate organs for transplantation,according to the risk of relapse after liver transplant.The present paper will describe the most recent evidence on the role of CTCs in determining the relapse of HCC,highlighting their potential clinical implication as novel tumor behavior biomarkers able to influence the surgical choice. | Francesca Carissimi Matteo Nazzareno Barbaglia Livia Salmi Cristina Ciulli Linda Roccamatisi Giuseppe Cordaro Venkata Ramana Mallela Rosalba Minisini Biagio Eugenio Leone Matteo Donadon Guido Torzilli Mario Pirisi Fabrizio Romano Simone Famularo | 2021 | World Journal of Gastrointestinal Surgery2021，13，9： | 0 |
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