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| 1 | Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases显示文摘Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic targets.Here,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic potential.Treatment with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and sepsis.We show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic effects.Because citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET formation.tACPA suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related stimuli.Moreover,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of IA.To our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner. | Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 2 | 帕克活性生物砂滤脱氮的四年运行经验显示文摘由于执行新的氮排放标准,位于鹿特丹西部Vlaardingen地区的排水厂'De Groote Lucht'需要改扩建以达到新要求。该厂在干旱季水量是4,350m3/h,最大水量为12,000m3/h。为了达到总氮的严格要求(总氮年平均小于10mg/L),该排水厂在1999年增设了Astrasand活性生物砂滤床作为脱氮后处理。该系统既能达到很高的脱氮效率,又能很好的去除SS。这篇文章报道了四年连续运行的条件和结果。 | Kramer J.P. Wouters J.W. Rosmalen Pvan | 2009 | 水工业市场2009，，3： | 3 |
| 3 | 帕克活性生物砂滤脱氮工艺的设计与运行显示文摘位于鹿特丹西部的De Groote Lucht污水厂的原处理工艺无法满足新的氮排放标准,因此进行了改扩建工程,增加了活性生物砂滤床作为三级处理工艺。改造后的处理系统既能达到很高的脱氮效率,又能较好地去除SS和COD,运行稳定,人工操作简单,可满足年平均总氮含量<10 mg/L的标准要求。 | Kramer J P Wouters J W Rosmalen P van | 2007 | 中国给水排水2007，23，6： | 3 |
| 4 | The association between neuroticism and self-reported common somatic symptoms in a population cohort显示文摘 | Judith G.M. Rosmalen Jan Neeleman Reinold O.B. Gans Peter de Jonge | 2007 | Journal of Psychosomatic Research2007，，3： | 2 |
| 5 | GFAP and S100B are biomarkers of traumatic brain injury: An observational cohort study显示文摘 | P.E. Vos B. Jacobs T.M.J.C. Andriessen K.J.B. Lamers G.F. Borm T. Beems M. Edwards C.F. Rosmalen J.L.M. Vissers | 2010 | Neurology2010，，20： | 1 |
| 6 | Acidic dissolution of zinc ferrite显示文摘 | ELGERSMA F KAMST G F WITKAMP G J van ROSMALEN G M | 1992 | Hydrometallurgy1992，29，13： | 1 |
| 7 | Primary nucleation induced by ultrasnnic cavitation显示文摘 | Virone C Kramer H J Rosmalen G M | 2006 | Journal of Crystal Growth2006，294，6： | 1 |
| 8 | Incorporation of Zinc in Continuous Jarosite Precipitation 显示文摘 | Elgersma F Witkamp G J Rosmalen G M van | 1993 | Hydrometallurgy1993，33，3： | 1 |
| 9 | Induction time and metastability limit in new phase formation显示文摘 | KASHCHIEV D VERDOES D yon ROSMALEN G M | 1991 | Journal of Crystal Growth1991，110，： | 1 |
| 10 | Oriented growth of silica molec- ular sieve crystals as supported films 显示文摘 | Jansen J C Rosmalen G M | 1995 | Journal of Crystal Growth1995，128，： | 1 |
| 11 | Simultaneous Dissolution of Zinc Ferrite and Precipitation of Ammonium Jarosite显示文摘 | Elgersma F Witkamp G J Van Rosmalen G | 1993 | Hydrometallurgy1993，34，1： | 1 |
| 12 | psychophysiological biomarkers explaining the association between depression and prognosis in coronary artery patients a critical review of the literature显示文摘 | de Jonge P Rosmalen JG Kema IP | 2010 | Neurosci Biobehav Rev2010，35，1： | 1 |
| 13 | Review: Nucleation in solutions revisited显示文摘 | KASHCHIEV D VAN ROSMALEN G M | 2003 | Cryst Res Technol2003，38，78： | 1 |
| 14 | 单个腺病毒颗粒的原子力显微镜液相成像及样品制备方法显示文摘原子力显微镜(Atomic force microscopy,AFM)作为一种纳米级高分辨率的探针扫描显微镜,在病毒形态学研究等领域有广泛的应用。为更好地利用AFM在接近病毒生理环境(液相)中观测单个病毒颗粒,选择合适的基底吸附病毒样品是重要的前提保障。本文介绍了一种病毒样品制备及AFM液相成像方法。首先制备疏水化处理的玻璃盖玻片作为吸附基底,再将观察样品腺病毒重组载体颗粒(Adenovirus type 5F35,Ad5F35)吸附于基底上,建立在液相下单个病毒颗粒的原子力显微镜成像方法。通过该方法获取了单个腺病毒颗粒在液相下的高分辨率纳米级高度图(height image),且病毒颗粒保持了约90nm的正确测量高度。实验结果表明疏水化处理的玻璃基底具有良好的吸附力,有助于病毒颗粒牢固地吸附在基底上,且不会引起较大的形变。本研究为AFM观测病毒等生物样品提供了一种较为合适的吸附基底和在液相中的AFM成像方法,对后期开展病毒形态结构、物理属性及其与宿主细胞受体相互作用的研究打下基础。 | 梁艳 李晨 Mariska G M van Rosmalen Gijs J L Wuite Wouter H Roos | 2015 | 病毒学报2015，31，6： | 1 |
| 15 | Prevalence of somatoform disorders and medically unexplained symptoms in old age populations in comparison with younger age groups : A systematic re- view 显示文摘 | HILDERINK PH COLLARD R ROSMALEN JG | 2013 | Aging Res Rev2013，12，1： | 1 |
| 16 | Lung cancer probability in patients with CT-detected pulmonary nodules: a pre- specified analysis of data from the NELSON trial of low-dose CT screening显示文摘 | Horeweg N van Rosmalen J Heuvelmans MA | 2014 | Lancet Oncol2014，15，12： | 1 |
| 17 | Review: nuclea- tion in solutions revisited显示文摘 | KASHCHIEV D VAN ROSMALEN G M | 2003 | Crystal Research and Technol- ogy2003，38，： | 1 |
| 18 | Cost-effectiveness of cervical cancer screening: cytology versus human papilla-mavirus DNA testing 显示文摘 | Van Rosmalen J de Kok IM van Ballegooijen M | 2012 | BJOG2012，119，6： | 1 |
| 19 | Pastille Purification in a Gravity Wash Column显示文摘 | Van Der Gun M A Bruinsma O S L Van Rosmalen G M | 2001 | Chemical Engineering Science2001，56，： | 1 |
| 20 | Precipitation of ultrafine organic crystals from the rapid expansion of supercritical solutionsovera capillary and a frit nozzle显示文摘 | Domingo C Berends E van Rosmalen G M | 1997 | Ournal of Supercritical Fluids1997，10，： | 1 |
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