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| 1 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Spontaneous intramural duodenal hematoma in type 2B von Willebrand disease显示文摘Intramural duodenal hematoma is a rare cause of a proximal gastrointestinal tract obstruction.Presentation of intramural duodenal hematoma most often occurs following blunt abdominal trauma in children,but spontaneous non-traumatic cases have been linked to anticoagulant therapy,pancreatitis,malignancy,vasculitis and endoscopy.We report an unusual case of spontaneous intramural duodenal hematoma presenting as an intestinal obstruction associated with acute pancreatitis in a patient with established von Willebrand disease,type 2B.The patient presented with abrupt onset of abdominal pain,nausea,and vomiting.Computed tomography imaging identified an intramural duodenal mass consistent with blood measuring 4.7 cm×8.7 cm in the second portion of the duodenum abutting on the head of the pancreas.Serum lipase was 3828 units/L.Patient was managed conservatively with bowel rest,continuous nasogastric decompression,total parenteral nutrition,recombinant factorⅧ(humateP)and transfusion.Symptoms resolved over the course of the hospitalization.This case highlights an important complication of an inherited coagulopathy. | Derrick D Eichele Meredith Ross Patrick Tang Grant F Hutchins Mark Mailliard | 2013 | World Journal of Gastroenterology2013，19，41： | 3 |
| 3 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 4 | Farming options for the Netherlands explored by multi-objective modeling 显示文摘 | TEN BERGE H F M VAN ITYERSUM M K ROSSING W A H | 2000 | Eur J Agron2000，13，23： | 1 |
| 5 | A review and update of animal toxicoses associated with fumonisin contaminated feeds and production of fumonisins by Fusarium isolates显示文摘 | ROSS P F RICE L G OSWEILER G D | 1992 | Mycopthol1992，117，： | 1 |
| 6 | Evolving role of self-eapangding metal stents in the treatmet of malignat dysphagia and fistulas 显示文摘 | Ross WA Alkassab F Lynch PM | 2007 | Gastrointest Endosc2007，65，1： | 1 |
| 7 | Immunogenicity of outer membrane components of Haemophilus ( Actinobacillus ) pleuropleumoniae 显示文摘 | Rapp V J Ross R F | 1988 | Can Vet J1988，29，： | 1 |
| 8 | Aminoguanidine ameliorates and L-arginine worsens brain damage from intraluminal middle cerebral artery occlusion显示文摘 | Zhang F Casey RM Ross ME | 1996 | Stroke1996，27，2： | 1 |
| 9 | Regulation of AMP-Activated Protein Kinase by a Pseudosubstrate Sequence on the Gamma Subunit显示文摘 | Scott J W Ross F A Liu J K | 2007 | EMBO J2007，26，3： | 1 |
| 10 | Cloning of porcine NRAMP1 and its induction by lipopolysaccharide,tumor necrosis factor alpha,and interleukin-1beta:Role of CD14 and mitogen-activated protein kinases显示文摘 | Zhang G Wu H Ross C R Minton J E and Blecha F | | 0，，03： | 1 |
| 11 | Spectral algorithm for pseudospcctral methods in optimal control 显示文摘 | Gong Q Ross I M Fahroo F | 2008 | Journal of Guidance Control and Dynamics2008，31，3： | 1 |
| 12 | Escherichia coli heat-labile enterotoxin promotes protective Thl7 responses against infection by driving innate IL-1 and IL-23 production显示文摘 | Brereton C F Sutton C E Ross P J | 2011 | J Immunol2011，186，10： | 1 |
| 13 | AMPK:a nutrient and energy sensor that maintains energy homeostasis显示文摘 | HARDIE D G ROSS F A HAWLEY S A | 2012 | Nature Reviews Molecular Cell Biology2012，13，4： | 1 |
| 14 | Localized acquired resistance to plant virus infection in hypersentive hosts显示文摘 | Ross A F | 1961 | Virology1961，14，： | 1 |
| 15 | Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione显示文摘 | LOPACHIN R M ROSS J F REID M L | 2002 | Neurotoxicology2002，23，1： | 1 |
| 16 | Endothelial dysfunction and inflammation predict development of diabetic nephropathy in the Irbesartan in Patients with Type 2 Diabetes and Microalbuminuria (IRMA 2) study 显示文摘 | Persson F Rossing P Hovind P | 2008 | Scand J Clin Lab Invest2008，68，8： | 1 |
| 17 | Cyclo-oxyenase-2 gene expression in neurons contributes to ischemic brain damage显示文摘 | Nogawa S Zhang F Ross ME | 1997 | J Neurosci1997，17，8： | 1 |
| 18 | Selective interactions between prostate fibroblast and epithelial cells in co-culture maintain the BPH phenotype显示文摘 | Bayne CW Ross M Donnelly F | 1998 | Urol Int1998，61，1： | 1 |
| 19 | Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity显示文摘 | Patel H C Ross F M Heenan L E | 2006 | Journal of Neuroscience Research2006，83，3： | 1 |
| 20 | The gene for toxic shock toxinis carryed by a family of mmobile pathogenicity islands in Staphyloccus aureus显示文摘 | Lindsay J A Ruzin A Ross H F | 1998 | Mol Microbiol1998，29，： | 1 |
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