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| 1 | Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis显示文摘AIM: To evaluate the association of known copy number variations(CNVs) in ulcerative colitis(UC) progressing to colorectal cancer.METHODS: Microsatellite instability analysis using the National Cancer Institute's panel of markers, and CNV association studies using Agilent 2 × 105 k arrays were done in tissue samples from four patient groups with UC: those at low risk(LR) or high risk of developing colorectal cancer, those with premalignant dysplastic lesions, and those with colitis-associated colorectal cancer(CAC). DNA from tissue samples of these groups were independently hybridized on arrays and analyzed. The data obtained were further subjected to downstream bioinformatics enrichment analysis to examine the correlation with CAC progression.RESULTS: Microarray analysis highlighted a progressive increase in the total number of CNVs [LR(n = 178) vs CAC(n = 958), 5.3-fold], gains and losses [LR(n = 37 and 141) vs CAC(n = 495 and 463), 13.4- and 3.3-fold, respectively], size [LR(964.2 kb) vs CAC(10540 kb), 10.9-fold] and the number of genes in such regions [LR(n = 119) vs CAC(n = 455), 3.8-fold]. Chromosomewise analysis of CNVs also showed an increase in the number of CNVs across each chromosome. There were 38 genes common to all four groups in the study; 13 of these were common to cancer genes from the Genetic Disease Association dataset. The gene set enrichment analysis and ontology analysis highlighted many cancerassociated genes. All the samples in the different groupswere microsatellite stable.CONCLUSION: Increasing numbers of CNVs are associated with the progression of UC to CAC, and warrant further detailed exploration. | Bhadravathi Marigowda Shivakumar Harish Rotti Thanvanthri Gururajan Vasudevan Aswath Balakrishnan Sanjiban Chakrabarty Ganesh Bhat Lakshmi Rao Cannanore Ganesh Pai Kapaettu Satyamoorthy | 2015 | World Journal of Gastroenterology2015，21，2： | 10 |
| 2 | Distribution of and changes in industrial carbondioxide production显示文摘 | Rotty R M | 1983 | Journal of Geophysical Research1983，88，2： | 1 |
| 3 | The viral replication complex is associated with the virulence of Newcastle disease virus显示文摘 | Dortmans J C Rotti P J Koch G | | 0，，19： | 1 |
| 4 | Cancer anorexia-cachexia syndrome显示文摘 | Muliawati Y Haroen H Rotty LW | 2012 | Acta Med Indones2012，44，2： | 1 |
| 5 | Carbon dioxide emissions from fossil fuels: A procedure for estimation and results for 1950-1982显示文摘 | Marland G Rotty R M | 1984 | Tellus1984，36，： | 1 |
| 6 | Carbon dioxide emission from fossil fuels: a procedure for estimation and results for 1950-1982 显示文摘 | Marland G Rotty R M | 1984 | Tellus1984，36，： | 1 |
| 7 | Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry显示文摘 | Shin I Rotty J Wu FY | 2004 | J Biol Chem2004，280，7： | 1 |
| 8 | Keratin 16 regulates innate immunity in response to epidemlal barrier breach显示文摘 | Lessard JC Pina-Paz S Rotty JD | 2013 | Proc Natl Acad Sci USA2013，110，19： | 1 |
| 9 | Carbon dioxide emissions from fossil fuels: A procedure for estimation and results for 1950-1982 显示文摘 | Marland G Rotty R M | 1984 | Telluz1984，36，： | 1 |
| 10 | Thermodynamics and his value as the sources of energy policy instrumentss显示文摘 | Rotty R M Van Artsdalen E R | 1978 | Energy1978，，3： | 1 |
| 11 | Establishing ITER-grade prop- erties in CuCrZr: The Indian experience显示文摘 | Rotti C Panda N Patel H | 2014 | Fusion Science and Technology2014，65，2： | 1 |
| 12 | Carbon dioxide from fissile fuels: a procedure forestimation and results 1950-1982 显示文摘 | Marland G Rotty R | 1984 | Tellus B1984，36，： | 1 |
| 13 | A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair显示文摘 | Rotty JD Coulombe PA | 2012 | J Cell Biol2012，197，3： | 1 |
| 14 | Thermal fatigue damage of CuCrZr alloys显示文摘 | CHATTERJEEA A MITRA R CHAKRABORTY A K ROTTI C RAY K K | 2013 | Journal of Nuclear Materials2013，443，13： | 1 |
| 15 | Keratin 16 regulates innate immunity in response to epidermal barrier breach 显示文摘 | Lessard JC Pina-Paz S Rotty JD | 2013 | Proc Natl Acad Sci U S A2013，110，19： | 1 |
| 16 | Carbon dioxide emissions from fossil fuels: a procedure for estimation and results for 1950 - 1982 显示文摘 | Marland G Rotty R M | 1984 | Tellus1984，36，： | 1 |
| 17 | Allogenic hemato-poietic stem cell as curative treatment in myelofibrosis 显示文摘 | Wardhana Datau E A Rotty L W | 2011 | Acta Med Indones2011，43，4： | 1 |
| 18 | Preliminary assess- ment of Treponema pallidum specific IgM antibody detection and a new rapid point-of-care assay for the diagnosis of syphilis in human immunodeficiency virus-1- infected patients 显示文摘 | Rotty J Anderson D Garcia M | 2010 | Int J STD AIDS2010，21，11： | 1 |
| 19 | Carbon dioxide emissions from fossil fuels:A procedure for estimation and results for 1950-1982显示文摘 | Marland G Rotty R M | 1984 | Tellus1984，，36： | 1 |
| 20 | Prosthetic particles modify the expression of bone-related proteins by human osteoblastic cells in vitro 显示文摘 | Zreiqat HC rotti TN Howlett CR | 2003 | Biomaterials2003，24，2： | 1 |
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