|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Vitamin D in esophageal cancer: Is there a role for chemoprevention?显示文摘Vitamin D has emerged as a promising anti-cancer agent due to its diverse biological effects on tumor differentiation, apoptosis and suppression of cellular proliferation. Current evidence suggests a protective role of vitamin D in colon cancer. The effect of vitamin D on esophageal cancer remains controversial. Multiple studies investigated the association between vitamin D and esophageal cancer, employing different modes of assessment of vitamin D status such as serum 25-hydroxyvitamin D levels, vitamin D dietary intake or exposure to ultraviolet B(UVB) radiation. Genetic variations of the vitamin D receptor(VDR) gene and VDR expression in esophageal specimens have also been investigated. Ecological studies evaluating exposure to UVB radiation yielded an inverse correlation with esophageal cancer. When vitamin D dietary intake was assessed, direct association with esophageal cancer was observed. However, circulating 25-hydroxyvitamin D concentrations showed inconsistent results. In this review article, we present a detailed summary of the current data on the effects of vitamin D on various histological subtypes of esophageal cancer and their precursor lesions. Well-powered prospective studies with accurate measurement of vitamin D status are needed before chemoprevention with vitamin D is recommended, as current evidence does not support a chemopreventive role of vitamin D against esophageal cancer. Future studies looking at the incidence of esophageal cancer in patients with pre-cancerous lesions(Barrett's esophagus and squamous cell dysplasia) receiving vitamin D supplementation are needed. | Carol Rouphael Afrin Kamal Madhusudhan R Sanaka Prashanthi N Thota | 2018 | World Journal of Gastrointestinal Oncology2018，10，1： | 5 |
| 2 | Lymphocytic esophagitis: Still an enigma a decade later显示文摘Lymphocytic esophagitis (LE) is a clinicopathologic entity first described by Rubio et al in 2006. It is defined as peripapillary intraepithelial lymphocytosis with spongiosis and few or no granulocytes on esophageal biopsy. This definition is not widely accepted and the number of lymphocytes needed to make the diagnosis varied in different studies. Multiple studies have described potential clinical associations and risk factors for LE, such as old age, female gender and smoking history. This entity was reported in inflammatory bowel disease in the pediatric population but not in adults. Other associations include gastroesophageal reflux disease and primary esophageal motility disorders. The most common symptom is dysphagia, with a normal appearing esophagus on endoscopy, though esophageal rings, webs, nodularities, furrows and strictures have been described. Multiple treatment modalities have been used such as proton pump inhibitors and topical steroids. Esophageal dilation seems to be therapeutic when dysphagia is present along with esophageal narrowing secondary to webs, rings or strictures. The natural history of the disease remains unclear and needs to be better delineated. Overall, lymphocytic esophagitis seems to have a chronic and benign course, except for two cases of esophageal perforation in the literature, thought to be secondary to this entity. | Carol Rouphael Ilyssa O Gordon Prashanthi N Thota | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 3 | Polymyxin B and doxycycline use in patients with multidrug-resistant Acinetobacter baumannii infections in the intensive care unit显示文摘 | Holloway K P Rouphael N G Wells J B | 2006 | Ann Pharrnacother2006，40，11： | 1 |
| 4 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati N J Vaughan C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
| 5 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati N J Vaughan C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
| 6 | Spectrum of CNS disease caused by rapidly growing mycobacteria显示文摘 | Talati N J Rouphael N Kuppalli K | 2008 | Lancet Infect Dis2008，8，6： | 1 |
| 7 | Polymyxin B and doxycycline use in patients with muhidrug resisitant acinetobacter baumanni, infections in the intensive care unit 显示文摘 | HOLLOWAY K P ROUPHAEL N G WELLS J B | 2006 | Ann Pharmacother2006，40，11： | 1 |
| 8 | Infections associated with haemophagocytic syndrome显示文摘 | Rouphael N G Talati N J Vaughan C | 2007 | Lancet In-fect Dis2007，7，12： | 1 |
| 9 | Infections associated with haemophagocytic syndrome显示文摘 | Rouphael N G Talati N J Vaughan C | 2007 | Lancet Infeet Dis2007，，7： | 1 |
| 10 | Skin ulcers misdiagnosed as pyodermagangrenosum显示文摘 | ROUPHAEL N G AYOUB N M TOMB R R | | 0，，11： | 1 |
| 11 | Molecular signatures of antibody responses derived from a systems biology study of five human vaccines 显示文摘 | Li S Rouphael N Duralsingham S | 2014 | Nat Immuno12014，15，2： | 1 |
| 12 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael N G Talati N J Vaughan C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
| 13 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati N J Vaughan C | 2007 | Lancet Infect Dis2007，7，： | 1 |
| 14 | Infections as- sociated with haemophagocytic syndrome 显示文摘 | Rouphael N G Talati N J Vaughan C | 2007 | Lancet In- fect Dis2007，，7： | 1 |
| 15 | Polymyxin B and doxyeycline ues in patients with multidrug-resistant Acinetobacter banmannii infections in the intensive care unit显示文摘 | HOLLOWAY K P ROUPHAEL N G WELLS J B | 2006 | Ann Pharmacother2006，40，14： | 1 |
| 16 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati N J VaughanC | 2007 | Lancet Infect Dis2007，7，： | 1 |
| 17 | Vaccination strategies to prevent tuberculosis in the new mil lennium: from BCG to new vaccine candidates显示文摘 | Franco-Paredes C Rouphael N del RC el al | 2006 | Int J Infec Dis2006，1，： | 1 |
| 18 | Polymyxin B and doxycycline use in patients with multidrug-Rrsisrant Acinetobacter baumannii infections in the intensive care unit 显示文摘 | Holloway K P Rouphael N G Wells J B | 2006 | Ann Pharmacother2006，40，11： | 1 |
| 19 | Clostridium difficle-associated diarrhea: an emerging threat to pregnant women 显示文摘 | Rouphael N G O 'Donnell J A Bhatnagar J | 2008 | Am J Obstet Gynecol2008，198，： | 1 |
| 20 | Infections associated with haemophagocytic syndrome 显示文摘 | Rouphael NG Talati N J Vaughan C | 2007 | Lancet Infect Dis2007，7，12： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员