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245篇 您的检索式：作者名="Rowe A J"

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	题名	作者	年代	出处	被引量
1	Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease显示文摘AIM To develop a human in vitro model of non-alcoholic fatty liver disease(NAFLD), utilising primary hepatocytes cultured in a three-dimensional(3D) perfused platform. METHODS Fat and lean culture media were developed to directly investigate the effects of fat loading on primary hepatocytes cultured in a 3D perfused culture system. Oil Red O staining was used to measure fat loading in the hepatocytes and the consumption of free fatty acids(FFA) from culture medium was monitored. Hepatic functions, gene expression profiles and adipokine release were compared for cells cultured in fat and lean conditions. To determine if fat loading in the system could be modulated hepatocytes were treated with known anti-steatotic compounds. RESULTS Hepatocytes cultured in fat medium were found to accumulate three times more fat than lean cells and fat uptake was continuous over a 14-d culture. Fat loading of hepatocytes did not cause any hepatotoxicity and significantly increased albumin production. Numerous adipokines were expressed by fatty cells and genes associated with NAFLD and liver disease were upregulated including: Insulin-like growth factorbinding protein 1, fatty acid-binding protein 3 and CYP7A1. The metabolic activity of hepatocytes cultured in fatty conditions was found to be impaired and the activities of CYP3A4 and CYP2C9 were significantlyreduced, similar to observations made in NAFLD patients. The utility of the model for drug screening was demonstrated by measuring the effects of known antisteatotic compounds. Hepatocytes, cultured under fatty conditions and treated with metformin, had a reduced cellular fat content compared to untreated controls and consumed less FFA from cell culture medium.CONCLUSION The 3D in vitro NAFLD model recapitulates many features of clinical NAFLD and is an ideal tool for analysing the efficacy of anti-steatotic compounds.	Tomasz Kostrzewski Terri Cornforth Sophie A Snow Larissa Ouro-Gnao Cliff Rowe Emma M Large David J Hughes	2017	World Journal of Gastroenterology2017，23，2：	6
2	Comparison of video shot boundary detection techniques 显示文摘	Boreczky J S Rowe L A	1996	Journal of Elec- tronic Imaging1996，5，2：	1
3	Localization of mrna for vascular endothelial growth factor (Vegf), angio- poietins and their receptors during the peri-implanta- tion period and early pregnancy in marmosets (Cal- lithrix Jacchus) 显示文摘	Rowe A J Wulff C Fraser H M	2003	Reproduction2003，126，2：	1
4	Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland 显示文摘	MAGA E A SHOEMAKER C F ROWE J D	2006	Journal of Dairy Science2006，89，2：	1
5	Avoidance of Thermal Damage in Grinding and Prediction of the Damage Threshold显示文摘	ROWE W B PETTIT J A BOYLE	1988	Annals of the CIRP1988，37，1：	1
6	Ultrahigh-vacuum studies of enhanced Raman scattering from pyridine on Ag surfaces显示文摘	Rowe J E Shank C V Zwemer D A	1980	Phys Rev Lett1980，44，：	1
7	A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion显示文摘	Rowe C L Connolly S A Chen J Jardetzky T S Longnecker R	2013	Virology2013，436，1：	1
8	Complex Compounds of Tertiary Phosphines and a Tertiary Arsine With Rhenium(Ⅴ),Rhenium(Ⅲ) and Rhenium(Ⅱ)显示文摘	CHATT J ROWE G A	1962	J Chem Soc1962，，：	1
9	Avoidance ofThermal Damage in Grinding and Prediction of theDamage Threshold显示文摘	ROWE W B PETTIT J A BOYLE A	1988	Annals of the CIRP1988，37，1：	1
10	Risk of malignancy after gamma knife stereotactic radiosurgery显示文摘	Rowe J Grainger A Walton L	2007	Neurosurgery2007，60，1：	1
11	Seven polymorphic microsatellite loci in honeybees (Apis mellifera) 显示文摘	ROWE D J RINDERER T E STELZER J A	1997	Insectes-Soc iaux1997，44，2：	1
12	MBE growth and properties of ZnO on sapphire and SiC substrates 显示文摘	Johnson M A L Fujita S Row landW H J		Electron Mater0，25，5：	1
13	Gamma knife radiosurgery for cerebral arteriovenous malformations显示文摘	Kemeny A A Radatz M W Rowe J G	2004	Acta Neurochir Suppl2004，91，：	1
14	Production and processing of milk from transgenic goats expressing human lysozyme in the mammary gland显示文摘	Maga E A Shoemaker C F Rowe J D	2006	J Dairy Sci2006，89，2：	1
15	Eosinophilie esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula显示文摘	Kelly K J Lazenby A J Rowe PC	1995	Gastroenterology1995，109，：	1
16	The frameless copper IUD(GyneFix) and the TCu380A IUD: results of an 8- year multicenter randomized comparative trial显示文摘	Meirik O Rowe P J Peregoudov A	2010	Contraception2010，81，5：	1
17	Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia显示文摘	DiNardo C D Propert K J Loren A W Paietta E Sun Z X Levine R L Straley K S Yen K Patel J P Agresta S Abdel-Wahab O Perl A E Litzow M R Rowe J M Lazarus H M Fernandez H F Margolis D J Tallman M S Luger S M Carroll M	2012	Blood2012，121，24：	1
18	Isolation of a cy topathic agent from human adenoids undergoing spontaneous degradation in tissue culture显示文摘	Rowe W P H uebner R J Gilmore L K et a l	1953	Proceedings of the Society for Experimental Biology and Medicine1953，84，：	1
19	Collagen biomechanics in cerebral arteries and bifurcations assessed by polarizing microscopy显示文摘	Rowe A J Finlay H M Canham P B	2003	J Vasc Res2003，40，4：	1
20	A distinct lineage of influenza A virus from bats显示文摘	Tong S Li Y Rivailler P Conrardy C Castillo D A Chen L M Recuenco S Ellison J A Davis C T York I A Turmelle A S Moran D Rogers S Shi M Tao Y Weil M R Tang K Rowe L A Sammons S Xu X Frace M Lindblade K A Cox N J Anderson L J Rupprecht C E Donis R O	2012	PANS2012，109，11：	1

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