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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Seasonal and spatial variation in the occurrence of vesicular - arbuscular (VA) mycorrkiza in salt marsh plants 显示文摘 | Van Duin WE Rozema J Ernst WHO | 1989 | Agriculture Ecosystems and Environment1989，29，： | 1 |
| 3 | Resoluble poly L-lacide plates and screws for the fixation of lygomatic fracture显示文摘 | Bos R M Rozema F R | 1987 | Oral Maxillofac Surg1987，45，： | 1 |
| 4 | Bioabsorbable plates and screws for internal fixation of madibular fracture显示文摘 | Bos RR M Rozema FR Boeing G | 1989 | Int J Oral Maxillofac Surg1989，18，： | 1 |
| 5 | Comparison of nodal risk formula and MR lymphography for predicting lymph node involvement in prostate cancer显示文摘 | Deserno WM Debats OA Rozema T | | 0，，： | 1 |
| 6 | siRNA delivery technologies for mammalian systems显示文摘 | Rozema DB Lewis DL | 2003 | Targets2003，2，6： | 1 |
| 7 | Toward solving the UV puzzle显示文摘 | ROZEMA J VAN GEEL B BJORN LO | 2002 | Science2002，296，： | 1 |
| 8 | Computer-aided optimization of choice and positioning of bone plates and screws used for internal fixation of mandibular fractures显示文摘 | Rozema FR Otten E Bos RR | 1992 | Int J Oral Maxillofac Surg1992，21，6： | 1 |
| 9 | 显示文摘 | Bergsma J E Rozema F R Bos R R M | 1995 | Biomaterials1995，16，： | 1 |
| 10 | Artificial chaperone-assistant refolding of denatured-reduced lysozyme: modulatin of the competition between renaturation and aggregation 显示文摘 | Rozema D Gellman S | 1996 | Biochemistry1996，35，15： | 1 |
| 11 | Late degradation tissue reponse to poly(L-lactide) bone plates and screws 显示文摘 | Bergsma EJ de Bruijn WC Rozema FR | 1995 | Biomaterials1995，16，： | 1 |
| 12 | Artificial chaperone-assistant refolding of carbonic anhydrase B显示文摘 | Rozema D Gellman S | 1996 | J Biol Chem1996，271，： | 1 |
| 13 | Stratospheric ozone reduction and ecosystem processes: enhanced UV-B radiation affects chemical quality and decomposition of leaves of the dune grassland species Calam agrostis epigeios显示文摘 | Rozema J TosseramsM Nelissen H J | 1997 | Plant Ecol1997，，128： | 1 |
| 14 | Late degradation tissue response to poly(-lactide) bone plates and screws显示文摘 | Bergsma J E De Bruijn W C Rozema F R | | 0，，01： | 1 |
| 15 | Resorbable poly(L-lactide)plates and screws for the fixation of zygomatie fractures显示文摘 | Bes RR Boering G Rozema FR | 1987 | J Oral Maxillofsc Surg1987，45，9： | 1 |
| 16 | Investigating the origin of Pb pollution in a terrestrial soil-plant-snail food chain by means of Pb isotope ratios显示文摘 | NOTTEN M J M WALRAVEN N BEETS C J VROON P ROZEMA J AERTS R | 2008 | Applied Geochemistry2008，23，6： | 1 |
| 17 | Hot- runner system boosts stack mold benefits显示文摘 | TRAVAGLINI V ROZEMA H | 1997 | Moderm Plastics Inter national1997，27，12： | 1 |
| 18 | Late degradation tissue response to poly(L-lactide)bone plates and screws显示文摘 | Bergsma JE De Bruijn WC Rozema FR | 1995 | Biomaterials1995，16，1： | 1 |
| 19 | Degradation of and tissue reaction to biodegradable poly(L-lactide) for use as internal fixation of fractures:a study in rats显示文摘 | Bos RR Rozema FR Boering G | 1991 | Biomaterials1991，12，1： | 1 |
| 20 | Biocompatibility and degradation mechanisms of predegraded and non-predegraded poly(lactide) implants: an animal study显示文摘 | J. E. Bergsma F. R. Rozema R. R. M. Bos A. W. M. Rozendaal W. H. Jong J. S. Teppema C. A. P. Joziasse | 1995 | Journal of Materials Science: Materials in Medicine1995，，12： | 1 |
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