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| 1 | Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy显示文摘The prevalence of skin cancer is rising along with the rapid population aging in recent years.Traditional therapies,such as surgical treatment,radiotherapy,chemotherapy,photodynamic therapy,and immunotherapy,may accompany serious side effects,limiting their clinical benefits.According to the biological characteristics of skin cancer,we have already established two kinds of synergetic systems of photothermal therapy(microneedle)and chemotherapy,containing gold nanorods(GNR).Although the microneedle system exhibited great potential for skin cancer treatment,the system could be still improved further.So,we designed a near-infrared lightresponsive 5-fluorouracil(5-Fu)and indocyanine green(ICG)loaded monomethoxy-poly(ethylene glycol)-polycaprolactone(MPEG-PCL)nanoparticle(5-Fu-ICG-MPEG-PCL),and then 5-Fu-ICG-MPEG-PCL was integrated with a hyaluronic acid dissolvable microneedle system(HA MN)to get 5-Fu-ICG-MPEG-PCL loaded HA MN for treating skin cancers,including human epidermoid cancer and melanoma.In this system,hyaluronic acid,the microneedle carrier,possesses good skin penetration ability and is approved by FDA as a pharmaceutical adjuvant;5-Fu is recommended by FDA for skin cancer treatment;ICG,a photothermal agent,possesses a strong photothermal ability and is approved by FDA for its use in the human body.We hypothesized that 5-Fu-ICG-MPEG-PCL could be delivered by the dissolvable microneedle through the skin,and the release behavior of the drug in the nanoparticle could be controlled by near-infrared light for achieving a single-dose cure of skin cancer,improving the cure rate of skin cancer and providing a new idea and possibility for the clinical treatment of skin cancer. | Ying Hao YuWen Chen XinLong He Fan Yang RuXia Han ChengLi Yang Wei Li ZhiYong Qian | 2020 | Bioactive Materials2020，5，3： | 17 |
| 2 | Key features of new particle formation events at background sites in China and their influence on cloud condensation nuclei显示文摘 | Xiaojing SHEN Junying SUN Xiaoye ZHANG Yangmei ZHANG Lu ZHANG Ruxia FAN | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 5 |
| 3 | Ultrasensitive graphene-Si position-sensitive detector for motion tracking显示文摘Motion tracking has attracted great attention in the fields of real-time tracking,nanorobotics,and targeted therapy.For achieving more accurate motion tracking,the highly sensitive position-sensitive detector(PSD)is desirable.Here,we demonstrate a meliorated PSD based on graphene-Si heterojunction for motion tracking.The position sensitivity of PSD was improved by employing surface engineering of graphene.Through modulating the transport property of graphene,nearly 20-fold increase of sensitivity was achieved under weak light,and at the same time,the detection limit power was reduced to^2 nW.A motion tracking system was developed based on the improved PSD,and human arm swing was tracked,which demonstrated high sensitivity and real-time tracking capabilities of the PSD.In addition,the PSD can support up to^10 kHz high-frequency tracking.This work provides a new strategy for improving the performance of PSD,and promotes the development of two-dimensional materials in novel optoelectronic devices. | Wenhui Wang Kaiyang Liu Jie Jiang Ruxia Du Litao Sun Wei Chen Junpeng Lu Zhenhua Ni | 2020 | InfoMat2020，2，4： | 3 |
| 4 | Structural characterizations of protonated homodimers of amino acids:Revealed by infrared multiple photon dissociation(IRMPD) spectroscopy and theoretical calculations显示文摘Infrared multiple photon dissociation(IRMPD) spectroscopic and theoretical studies of protonated homodimers of amino acids generated by electrospray ionization in the gas phase have been reviewed.Results show that proton affinity(PA) may be applied as a probe to predict their structural type: saltbridged or charge-solvated. Proline can be viewed as a reference. For an amino acid with a PA value higher than that of proline, the most stable conformation of its protonated homodimer tends to prefer saltbridged conformation; otherwise, charge-solvated conformation is expected to be the most stable.However, side chain effects may cause the inaccuracy in structural determination due to the strong interactions with the charge, which makes the charge-solvated structure more stable even for species with high PA values. Temperature effect on distribution of different isomers is also very important. In lots of cases, the coexistence of multiple isomers is general, which makes the explanation of an overall IRMPD spectrum difficult. So a statistical view on the distribution of optimized isomers is very helpful. | Lifu Ma Juan Ren Ruxia Feng Kailin Zhang Xianglei Kong | 2018 | Chinese Chemical Letters2018，29，9： | 3 |
| 5 | Dietary Enteromorpha polysaccharide-Zn supplementation regulates amino acid and fatty acid metabolism by improving the antioxidant activity in chicken显示文摘Background:Enteromorpha prolifera(E.prolifera)polysaccharide has become a promising feed additive with a variety of physiological activities,such as anti-oxidant,anti-cancer,anti-diabetic,immunomodulatory,hypolipidemic,and cation chelating ability.However,whether Enteromorpha polysaccharide-trace element complex supplementation regulates amino acid and fatty acid metabolism in chicken is largely unknown.This study was conducted to investigate the effects of E.prolifera polysaccharide(EP)-Zn supplementation on growth performance,amino acid,and fatty acid metabolism in chicken.Methods:A total of 184 one-day-old Ross-308 broiler chickens were randomly divided into two treatment groups with 8 replicates,12 chickens per replicate,and fed either the basal diet(control group)or basal diet plus E.prolifera polysaccharide-Zinc(400 mg EP-Zn/kg diet).Results:Dietary EP-Zn supplementation significantly increased(P<0.05)the body weight,average daily gain,muscle antioxidant activity,serum HDL level,and reduced serum TG and LDL concentration.In addition,dietary EPZn supplementation could modulate ileal amino acid digestibility and upregulate the mRNA expression of amino acid transporter genes in the jejunum,ileum,breast muscle,and liver tissues(P<0.05).Compared with the control group,breast meat from chickens fed EP-Zn had higher(P<0.05)Pro and Asp content,and lower(P<0.05)Val,Phe,Gly,and Cys free amino acid content.Furthermore,EP-Zn supplementation upregulated(P<0.05)the mRNA expressions of mTOR and anti-oxidant related genes,while down-regulated protein degradation related genes in the breast muscle.Breast meat from EP-Zn supplemented group had significantly lower(P<0.05)proportions ofΣn-3 PUFA,and a higher percentage ofΣn-6 PUFA and the ratio of n-6/n-3 PUFA.Besides,EP-Zn supplementation regulated lipid metabolism by inhibiting the gene expression of key enzymes involved in the fatty acid synthesis and activating genes that participated in fatty acid oxidation in the liver tissue.Conclusions:It is concluded that EP-Zn complex supplementation regulates apparent ileal amino acid digestibility,enhances amino acid metabolism,and decreases oxidative stress-associated protein breakdown,thereby improving the growth performance.Furthermore,it promotes fatty acid oxidation and restrains fat synthesis through modulating lipid metabolism-related gene expression. | Teketay Wassie Xinyi Duan Chunyan Xie Ruxia Wang Xin Wu | 2022 | Journal of Animal Science and Biotechnology2022，13，3： | 3 |
| 6 | Sustained co-delivery of gemcitabine and cis-platinum via biodegradable thermo-sensitive hydrogel for synergistic combination therapy of pancreatic cancer显示文摘Pancreatic cancer is one of the most devastating cancers with poor prognosis and no significant change in the survival rate over the past decades.Localized targeted drug delivery through interventional endoscopic ultrasonography-guided fine-needle injection (EUS-FNI) is an attractive and minimally invasive strategy for inoperable pancreatic cancer.An injectable in-situ formed long-lasting drug delivery system is a promising alternative for the localized treatment of pancreatic cancer via EUS-FNI.Here,a biodegradable thermo-sensitive copolymer hydrogel for the co-delivery of anticancer agents gemcitabine (GEM) and cis-platinum (DDP) was developed.This hydrogel is a free flowable liquid at room temperature that changes into a semi-solid hydrogel following injection in response to the physiological temperature.Both in vitro and in vivo drug release behaviors indicate sustained drug release of this delivery system.Synergistic cellular proliferation inhibition and desirable apoptosis promotion have been found when pancreatic cancer Bxpc-3 cells were co-cultured with this GEM-DDP/hydrogel system.After a single intratumoral injection,the dual-drug loaded hydrogel formulation exhibited superior anti-tumor efficacy and minimized systemic side effect on pancreatic cancer xenograft mouse model in comparison to the intravenously injected free GEM and DDP combination.In addition,a strong synergistic therapeutic effect of the GEM-DDP/hydrogel system against pancreatic cancer has been found in vitro and in vivo compared to the single-drug loaded hydrogel composites.The obtained findings suggest this developed thermo-sensitive copolymer hydrogel system as a potential universal carrier for the localized targeted delivery of multi-drugs,for use in a variety of inoperable solid tumors. | Kun Shi Bingxin Xue Yanpeng Jia Liping Yuan Ruxia Han Fan Yang Jinrong Peng Zhiyong Qian | 2019 | Nano Research2019，12，6： | 3 |
| 7 | Dandelion-Like Bi_(2)S_(3)/rGO hierarchical microspheres as high-performance anodes for potassium-ion and half/full sodium-ion batteries显示文摘Sodium-ion batteries (SIBs) and potassium-ion batteries (PIBs) have been considered as attractive alternatives for next-generation battery systems, which have promising application potential due to their earth abundance of potassium and sodium, high capacity and suitable working potential, however, the design and application of bi-functional high-performance anode still remain a great challenge up to date. Bismuth sulfide is suitable as anode owing to its unique laminar structure with relatively large interlayer distance to accommodate larger radius ions, high theoretical capacity and high volumetric capacity etc. In this study, dandelion-like Bi_(2)S_(3)/rGO hierarchical microspheres as anode material for PIBs displayed reversible capacity, and 206.91 mAh·g^(−1) could be remained after 1,200 cycles at a current density of 100 mA·g^(−1). When applied as anode materials for SIBs, 300 mAh·g^(−1) could be retained after 300 cycles at 2 A·g^(−1) and its initial Coulombic efficiency is as high as 97.43%. Even at high current density of 10 A·g^(−1), 120.3 mAh·g^(−1) could be preserved after 3,400 cycles. The Na_(3)V_(2)(PO_(4))_(3)@rGO//Bi_(2)S_(3)/rGO sodium ion full cells were successfully assembled which displays stable performance after 60 cycles at 100 mA·g^(−1). The above results demonstrate that Bi2S3/rGO has application potential as high performance bi-functional anode for PIBs and SIBs. | Xiuping Sun Lu Wang Chuanchuan Li Debao Wang Iqbal Sikandar Ruxia Man Fang Tian Yitai Qian Liqiang Xu | 2021 | Nano Research2021，14，12： | 2 |
| 8 | Microstructure Evolution and Mechanical Behavior of Laser Melting Deposited TA15 Alloy at 500℃ under In-Situ Tension in SEM显示文摘TA15 alloy fabricated by laser melting deposition was investigated at 500℃ under tensile deformation. The damage behavior of microstructure was analyzed by the real time observation of the microstructure evolution, microcracks initiation and propagation using in-situ tensile equipment fitted in the SEM chamber. Finally, the mechanism of fracture was discussed. The result showed anisotropic mechanical properties in X-and Z-direction. The existence of columnar β grains and its orientation to the tensile direction were the major factors inducing the anisotropic mechanical properties. As compared to Z-direction specimen, high tensile strength was observed in X-direction specimen due to the resistance in slips propagation provided by the prior-β grain boundaries( β GBs). Accumulation of the cracks at prior β GB caused the shear fracture. In case of Z-direction specimen, parallel orientation of prior β GB and GB α with the tensile direction resulted in a homogeneous deformation. The high reduction of cross section showed the enhanced ductile characteristics at high temperature. | Muhammad Rizwan Junxia Lu Fei Chen Ruxia Chai Rafi Ullah Yuefei Zhang Ze Zhang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，9： | 2 |
| 9 | Intracellular aggregation of peptide-reprogrammed small molecule nanoassemblies enhances cancer chemotherapy and combinatorial immunotherapy显示文摘The intracellular retention of nanotherapeutics is essential for their therapeutic activity.The immobilization of nanotherapeutics inside target cell types can regulate various cell behaviors.However,strategies for the intracellular immobilization of nanoparticles are limited.Herein,a cisplatin prodrug was synthesized and utilized as a glutathione(GSH)-activated linker to induce aggregation of the cisplatin prodrug/IR820/docetaxel nanoassembly.The nanoassembly has been reprogrammed with peptidecontaining moieties for tumor-targeting and PD-1/PD-L1 blockade.The aggregation of the nanoassemblies is dependent on GSH concentration.Evaluations in vitro and in vivo revealed that GSH-induced intracellular aggregation of the nanoassemblies enhances therapeutic activity in primary tumors by enhancing the accumulation and prolonging the retention of the chemotherapeutics in the tumor site and inducing reactive oxygen species(ROS)generation and immunogenic cell death.Moreover,the nanoassemblies reinvigorate the immunocytes,especially the systemic immunocytes,and thereby alleviate pulmonary metastasis,even though the population of immunocytes in the primary tumor site is suppressed due to the enhanced accumulation of chemotherapeutics.This strategy provides a promising option for the intracellular immobilization of nanoparticles in vitro and in vivo. | Jinrong Peng Yao Xiao Qian Yang Qingya Liu Yu Chen Kun Shi Ying Hao Ruxia Han Zhiyong Qian | 2021 | Acta Pharmaceutica Sinica B2021，11，4： | 2 |
| 10 | Review of a new bone tumor therapy strategy based on bifunctional biomaterials显示文摘Bone tumors,especially those in osteosarcoma,usually occur in adolescents.The standard clinical treatment includes chemotherapy,surgical therapy,and radiation therapy.Unfortunately,surgical resection often fails to completely remove the tumor,which is the main cause of postoperative recurrence and metastasis,resulting in a high mortality rate.Moreover,bone tumors often invade large areas of bone,which cannot repair itself,and causes a serious effect on the quality of life of patients.Thus,bone tumor therapy and bone regeneration are challenging in the clinic.Herein,this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy.The selected bifunctional materials include 3D-printed scaffolds,nano/microparticle-containing scaffolds,hydrogels,and bone-targeting nanomaterials.Numerous related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were reviewed.Finally,a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is discussed.This review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering. | Jinfeng Liao Ruxia Han Yongzhi Wu Zhiyong Qian | 2021 | Bone Research2021，9，2： | 2 |
| 11 | The antigenicity of SARS-CoV-2 Delta variants aggregated 10 high-frequency mutations in RBD has not changed sufficiently to replace the current vaccine strain显示文摘Emerging SARS-CoV-2 variants are the most serious problem for COVID-19 prophylaxis and treatment.To determine whether the SARS-CoV-2 vaccine strain should be updated following variant emergence like seasonal flu vaccine,the changed degree on antigenicity of SARS-CoV-2 variants and H3N2 flu vaccine strains was compared.The neutralization activities of Alpha,Beta and Gamma variants’spike protein-immunized sera were analysed against the eight current epidemic variants and 20 possible variants combining the top 10 prevalent RBD mutations based on the Delta variant,which were constructed using pseudotyped viruses.Meanwhile,the neutralization activities of convalescent sera and current inactivated and recombinant protein vaccine-elicited sera were also examined against all possible Delta variants.Eight HA protein-expressing DNAs elicited-animal sera were also tested against eight pseudotyped viruses of H3N2 flu vaccine strains from 2011–2019.Our results indicate that the antigenicity changes of possible Delta variants were mostly within four folds,whereas the antigenicity changes among different H3N2 vaccine strains were approximately 10–100-fold.Structural analysis of the antigenic characterization of the SARS-CoV-2 and H3N2 mutations supports the neutralization results.This study indicates that the antigenicity changes of the current SARS-CoV-2 may not be sufficient to require replacement of the current vaccine strain. | Jiajing Wu Jianhui Nie Li Zhang Hao Song Yimeng An Ziteng Liang Jing Yang Ruxia Ding Shuo Liu Qianqian Li Tao Li Zhimin Cui Mengyi Zhang Peng He Youchun Wang Xiaowang Qu Zhongyu Hu Qihui Wang Weijin Huang | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 1 |
| 12 | Ag2S nanoparticles as an emerging single-component theranostic agent显示文摘Last two decades,with the rapid changes and development of nanotechnology and biological materials,diverse multi-functional nanomaterials emerging,which offers a novel way to treat and diagnose diseases,and therefore spawned the new biomedical technology of theranostics,which integrates the treatment and diagnosis or monitoring of diseases into one.Ag2S as a bio-nanomaterial with low biotoxicity has attracted more and more attention due to its good photoluminescence properties and fluorescence imaging of small animals in the second near-infrared region(NIR-Ⅱ).Meanwhile,Ag2S has the ability to absorb near-infrared light strongly because of its local surface plasma resonance(LSPR)effect and had become a kind of photothermal conve rters with good photothermal conve rsion efficiency.More interestingly,both photothermal effect and fluorescence characteristics of Ag2S nanoparticles(NPs)are closely related to their particle sizes.However,the relationship between photothermal effect and fluorescence characteristics of Ag2S NPs and their sizes has not been reviewed so far.Herein,the synthesis methods and influencing factors of synthesize Ag2S NPs with different sizes were compared firstly,and then the photothermal effect and fluorescence characte ristics of Ag2S NPs with different sizes were summarized.Finally,the possibilities and challenges of using Ag2S NPs to construct theranostic agent were discussed in the end. | Ruxia Han Jinrong Peng Yao Xiao Ying Hao Yanpeng Jia Zhiyong Qian | 2020 | Chinese Chemical Letters2020，31，7： | 1 |
| 13 | Phosphorus-doping-tuned PtNi concave nanocubes with high-index facets for enhanced methanol oxidation reaction显示文摘Surface engineering has been found to be an efficient strategy to boost the catalytic performance of noble-metal-based nanocatalysts.In this work,a small amount of P was doped to the surface of PtNi concave cube(P-PtNi CNC).Interestingly,the P-PtNi CNC nanocatalyst shows an enhanced methanol oxidation reaction(MOR)performance with achieving 8.19 times of specific activity than that of comercial Pt/C.The electrochemical in situ Fourier transform infrared spectroscopy(FTIR)results reveal that the surface P doping promotes the adsorption energy of OH,enhancing the resistance against CO poisoning.Therefore,the intermediate adsorbed CO(COads)reacted with adsorbed OH(OHads)through the Langmuir–Hinshelwood(LH)mechanism to generate CO_(2)and release surface active sites for further adsorption.This work provides a promising strategy via the incorporation of non-metallic elements into the PtNi alloys bounded with high-index facets(HIFs)as efficient fuel cell catalysts. | Aixin Fan Congli Qin Ruxia Zhao Haixiao Sun Hui Sun Xiaoping Dai Jin-Yu Ye Shi-Gang Sun Yanhong Lu Xin Zhang | 2022 | Nano Research2022，15，8： | 1 |
| 14 | Erratum to “Near-infrared responsive 5-fluorouracil and indocyanine green loaded MPEG-PCL nanoparticle integrated with dissolvable microneedle for skin cancer therapy” [Bioact. Mater. 5 (2020) 542–552]显示文摘This is an erratum to our published paper,the scale bar in Fig.6A was wrong[1].In the paper mentioned above,the scale bar in Fig.6A was wrong[1].We missed a decimal point of the scale bar.The correct scale bar of 5-Fu-ICG-MPEG-PCL@HA MN should be 1.00 mm instead of 100 mm.We have corrected the scale bar in Fig.6 as follows. | Ying Hao YuWen Chen XinLong He Fan Yang RuXia Han ChengLi Yang Wei Li ZhiYong Qian | 2021 | Bioactive Materials2021，6，1： | 0 |
| 15 | Studies on the Preparation of Polymer Spherical Symmetry GRIN Sphere and Controlling its Gradient Index Distribution显示文摘In this paper, a polymer spherical symmetry GRIN sphere lens were prepared by the suspension-diffusion-copolymerization(SDC) technique, selecting methyl methacrylate(MMA) as monomer M1 and acrylic 2,2,2-trifluoroethyl ester(3FEA) as M2. The radial distribution of refractive index of the lens was measured by the shearing interference method, which demonstrated that the quadratic refractive-index distribution was formed in the sphere lens, and its Δn=0.019. | RuXIA YuChuanZHANG YouMinYI ShiWeiSHI QunYANG QiangYU | 2004 | Chinese Chemical Letters2004，15，5： | 0 |
| 16 | Adhesive chitosan-based hydrogel assisted with photothermal antibacterial property to prompt mice infected skin wound healing显示文摘Bacterial infection of wounds is an escalating medical problem,issuing threats to both global public health and personal health.Photothermal antibacterial technology as a novel sterilization strategy has outstanding sterilization efficiency,high safety and low risk of emergence of drug-resistant bacteria.By combining inherent antibacterial activity and light-assisted antibacterial treatment,developing novel multifunctional dressings with synergistic high-efficiency antibacterial effects and also promoting wound healing possesses attractive advantages in the field of treating bacterial wound infections in clinical care.Herein,a multifunctional hydrogel formed by in situ photo-cross linking was designed and prepared by first grafting methacrylic anhydride as a photosensitizer onto chitosan,and then introducing oxidatively synthesized polydopamine(PDA).The physicochemical characterizations of the synthesized hydrogels demonstrated their tunability certainly associated with PDA concentration,including pore size,water swelling,rheological properties and in vitro degradability.In addition,the composite hydrogels exhibited good adhesion,anti-oxidation and photothermal properties due to the existence of PDA.Within 10min upon exposure to 808 nm near-infrared(NIR)light irradiation,this hydrogel system displayed outstanding antibacterial activity against Staphylococcus aureus with almost 100%killing efficiency,of which rapid efficient sterilization plays a significant role in wound healing.Moreover,the hydrogel is capable of cytocompatibility and has low toxicity to murine fibroblasts(L929 and NIH/3T3).In the full-thickness wound defect infection model in mice,the wound closure ratio,inflammatory response,fibroblasts,neovascularization and epithelialization were measured.Animal experiments also reveal that the hydrogel assisted with NIR laser irradiation can inhibit effectively infection at an early stage and accelerate the wound healing process.In summary,this novel multifunctional injectable hydrogel exhibits excellent swelling capacity,bio-adhesion,antioxidant property,photothermal activity,efficient antibacterial property and facilitates skin healing,which has great promising application as a medical dressing biomaterial in infected wound carefields. | Shuang Cheng Meng Pan Danrong Hu Ruxia Han Lang Li Zhongwu Bei Yicong Li Ao Sun Zhiyong Qian | 2023 | Chinese Chemical Letters2023，34，12： | 0 |
| 17 | Change in elastic properties during room-temperature aging in body-centered cubic Mg-Li and Mg-Li-Al single crystals显示文摘Biodegradable materials,with many advantages over conventionally used non-biodegradable materials,have received much attention owing to the elimination of the need for a secondary surgery for the removal of implants after implantation.Compared with other biodegradable ceramics and/or polymers,Mg alloys are considered to be the most promising biodegradable orthopedic materials because they feature not only high specific strength and compressive yield strength but also a low Young’s modulus,which is comparable to that of human bones(10-30 GPa)[1,2]. | Ruxia Liu Shota Higashino Koji Hagihara Lianmeng Zhang Tohru Sekino Masakazu Tane | 2022 | Journal of Materials Science & Technology2022，，14： | 0 |
| 18 | Bioreactor performance and microbial community dynamics in a production-scale biogas plant in northeastern China显示文摘In cold regions,heating is necessary to maintain the continuous and steady year-round operation of biogas fermentation.In this study,changes in the liquid composition,biogas production,and microbial diversity in heated-and unheated-phase samples were evaluated in a production-scale biogas plant that was fed continuously with cattle manure as a mono-substrate in Heilongjiang province in northeastern China.The volatile solid(VS)and volatile fatty acid(VFA)contents both gradually decreased in the heated and unheated fermentation processes.The chemical oxygen demand(COD)removal efficiency in the unheated phase sampled on June 15(s-6-15)and October 15(a-10-15)and in the heated phase sampled on January 15(w-1-15)was 63.35%,44.2%and 44.0%,respectively.The biogas production yields were in agreement with the results obtained for the VS and VFA contents and COD removal efficiency.The performance of the reactor in the heated phase was less efficient than that in the unheated phase,and the biogas production efficiency in June-August was higher than that in the other months.However,the CH4 content in the biogas remained similar all year.Moreover,ARDRA(Amplified Ribosomal DNA Restriction Analysis)was used to study the microbial community composition in the fermentation process.The results showed that the methanogenic archaeal consortium consisted mainly of members of the genera Methanomicrobiales and Methanosarcinales.In the heated phase,hydrogenotrophic methanogens represented the dominant methanogen in w-1-15 feedstock.After fermentation,the strict aceticlastic methanogen Methanosaeta became the dominant methanogen.In the unheated phase,the hydrogenotrophic methanogens and aceticlastic methanogens were equivalent in s-6-15 feedstock and effluent,and aceticlastic methanogens were dominant in both a-10-15 feedstock and effluent.Assessments of the bacteria diversity of the microbial communities revealed that the common strains in the feed and effluent of the three samples included the rumen bacteria,Bacteroides,Clostridium,Ruminococcaceae and Proteobacteria. | Gao Yamei Yang Anyi Bao Jun Ma Ruxia Yan Lei Wang Yanjie Wang Weidong | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 0 |
| 19 | Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients显示文摘Antibody-dependent cellular cytotoxicity(ADCC)responses to viral infection are a form of antibody regulated immune responses mediated through the Fc fragment.Whether severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)triggered ADCC responses contributes to COVID-19 disease development is currently not well understood.To understand the potential correlation between ADCC responses and COVID-19 disease development,we analyzed the ADCC activity and neutralizing antibody response in 255 individuals ranging from asymptomatic to fatal infections over 1 year post disease.ADCC was elicited by 10 days post-infection,peaked by 11-20 days,and remained detectable until 400 days post-infection.In general,patients with severe disease had higher ADCC activities.Notably,patients who had severe disease and recovered had higher ADCC activities than patients who had severe disease and deceased.Importantly,ADCC activities were mediated by a diversity of epitopes in SARS-COV-2-infected mice and induced to comparable levels against SARS-CoV-2 variants of concern(VOCs)(B.1.1.7,B.1.351,and P.1)as that against the D614G mutant in human patients and vaccinated mice.Our study indicates anti-SARS-CoV-2 ADCC as a major trait of COVID-19 patients with various conditions,which can be applied to estimate the extra-neutralization level against COVID-19,especially lethal COVID-19. | Yuanling Yu Meiyu Wang Xiaoai Zhang Shufen Li Qingbin Lu Haolong Zeng Hongyan Hou Hao Li Mengyi Zhang Fei Jiang Jiajing Wu Ruxia Ding Zehua Zhou Min Liu Weixue Si Tao Zhu Hangwen Li Jie Ma Yuanyuan Gu Guangbiao She Xiaokun Li Yulan Zhang Ke Peng Weijin Huang Wei Liu Youchun Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 0 |
| 20 | Sustained co-delivery of 5-fluorouracil and cis-platinum via biodegradable thermo-sensitive hydrogel for intraoperative synergistic combination chemotherapy of gastric cancer显示文摘Gastric cancer is the fifth most common cancer and the third leading cause of cancer death worldwide,posing a severe threat to human health.Surgical resection remains the most preferred option for gastric cancer treatment.However,for advanced gastric cancer,the curative effect of surgical resection is usually limited by the local recurrence,peritoneal carcinomatosis,or distal metastasis.Intraoperative chemotherapy is an attractive in situ adjuvant treatment strategy to reduce the recurrence and metastasis after surgical resection.Here,we designed a 5-fluorouracil(5-FU)and cis-platinum(DDP)co-delivery system based on a biodegradable temperature-sensitive hydrogel(PDLLA-PEG-PDLLA,PLEL)for intraoperative adjuvant combination chemotherapy of gastric cancer.This 5-FU+DDP/PLEL hydrogel system characterized by a special sol-gel phase transition in response to physiological temperature and presented sustained drug release in vitro and in vivo.A strong synergistic cell proliferation inhibition and apoptosis promotion of 5-FU+DDP/PLEL were observed against gastric cancer MKN45-luc cells.After intraperitoneal injection,the dual-drug loaded hydrogel formulation showed superior anti-tumor effects than the single-drug carrying hydrogels and combination of free 5-FU and DDP on the gastric cancer peritoneal carcinomatosis model.The use of hydrogel for dual-drug delivery had benefited to fewer side effects as well.What’s more,we established a mouse model for postsurgical residual tumors and peritoneal carcinomatosis of gastric cancer,in which the intraoperative administration of 5-FU+DDP/PLEL also remarkably inhibited the local recurrence of the orthotopic tumors and the growth of the abdominal metastatic tumors,resulting in an extended lifetime.Hence,this developed dual-drug loaded hydrogel system has great potential in the intraoperative chemotherapy of gastric cancer,that suggests a clinically-relevant and valuable option for postsurgical management of gastric cancer. | Wen Chen Kun Shi Jie Liu Peipei Yang Ruxia Han Meng Pan Liping Yuan Chao Fang Yongyang Yu Zhiyong Qian | 2023 | Bioactive Materials2023，，5： | 0 |
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