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| 1 | Prefoldins Negatively Regulate Cold Acclimation in Arabidopsis thaliana by Promoting Nuclear Proteasome-Mediated HY5 Degradation显示文摘冷环境适应的过程是从适度的区域的许多植物在暴露于低不会结冻的温度以后增加他们的结冰忍耐的重要适应回答。这回答的正确发展依靠调整寒冷应答的基因的表示模式的很多个抄写因素的合适的累积。多重研究揭示了涉及支持这些抄写因素的累积的许多分子的机制。然而,有趣地,机制在控制如此的累积保证他们的足够的层次仍然保持大部分未知含有。在这个工作,我们证明 prefoldins (PFD ) 控制 HY5 的层次,有在由激活 anthocyanin 生合成的冷环境适应的一个关键角色的一个 Arabidopsis 抄写因素,响应低温度。在他们与 HY5 交往的地方,我们的结果证明在冷条件下面, PFD 通过 DELLA 依赖的机制积累进原子核,触发它的 ubiquitination 和随后的降级。接着, HY5 的降级将导致 anthocyanin 生合成变细,保证冷环境适应的精确发展。这些调查结果揭开为在对不能生活的压力的工厂回答的 PFD 的未预见到的原子功能。 | Carlos Perea-Resa Miguel A. Rodriguez-Milla Elisa Iniesto Vicente Rubio Julio Salinas | 2017 | Molecular Plant2017，10，6： | 8 |
| 2 | Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats显示文摘Aim: To evaluate the effect of the alcoholic extract of Lepidium meyenii (Maca) on the spermatogenesisin male rats. Methods: In Holtzman rats, Maca alcoholic extract (5 %) was given by oral route at doses of 48 mg/day or 96 mg/day for 7 days, 14 days and 21 days. Testicular function was assessed by measurements of lengths of different stages of seminiferous epithelia and by epididymal sperm count. Results: Ethanolic extract of Maca increased the length of stages IX-XI of seminiferous epithelium at treatment day 7, day 14 and day 21. Progression of spermatogenesis was evident only after day 21 when lengths of stages XII-XIV of seminiferous epithelium were increased; at day 7 and day 14, no important change in spermatogenesis was observed. Epididymal sperm count was increased with 48 mg/day at all times. With 96 mg/day an increase in sperm count was observed at day 7, but it was reduced at day 14 and day 21 of treatment. Serum testosterone levels were not affected. Conclusion: The alcoholic extract of Maca activates onset ant progression of spermatogenesis at 48 mg/day or 96 mg/day in rats. | Gustavo F. Gonzales Julio Rubio Arturo Chung Manuel Gasco León Villegas | 2003 | Asian Journal of Andrology2003，5，4： | 6 |
| 3 | Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice 显示文摘 | Rubio Julio Dang Haixia Gong Mengjuan | 2007 | Food Chem Toxicol2007，45，10： | 1 |
| 4 | Aqueous and hydroalcoholic extracts of Black Maca (Lepidium meyenii) improve scopolamine-induced memory impairment in mice显示文摘 | Julio Rubio Haixia Dang Mengjuan Gong | 2007 | Food and Chemical Toxicology2007，45，10： | 1 |
| 5 | Pharmacokinetics of Enrofloxacin Given by the Oral,Intravenous and Intramuscular Routes in Broiler Chickens显示文摘 | José Julio de Lucas Joaquín Luis Navarro Sonia Rubio | 1999 | Canadian Journal of Veterinary Research1999，63，3： | 1 |
| 6 | Semen quality in peruvian pesticide applicators: association between urinary organophosphate metabolites and semen parameters 显示文摘 | Sandra Yucra Manuel Gasco Julio Rubio | 2008 | Environmental Health2008，59，7： | 1 |
| 7 | Effect of short-term andlong-term treatments with three ecotypes of Lepidiummeyenii ( MACA) on spermatogenesis in rats 显示文摘 | Gonzales Carla Rubio Julio Gasco Manuel Nieto Jessica Yucra Sandra Gonzales Gustavo F | 2006 | Journal ofethnopharmacology2006，103，44： | 1 |
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