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| 1 | Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex显示文摘Pluripotent 干细胞(PSC ) 在他们的快速的增长和作为结果的染色体不稳定性期间怀有组成的 DNA 复制应力在再生药妨碍他们的应用。理解复制的规章的机制在 PSC 强调反应因此是重要的。这里,我们报导胚胎的干细胞(转换字符) 是的那只老鼠比在解决复制应力的区分的房间优异。明确地,转换字符利用唯一的跳动 Filia 的蛋白质高效地支持阻止的复制的重启的复杂依赖者的机制分叉,因此维持 genomic 稳定性。转换字符特定的跳动 Filia 的建筑群在正常条件下面住在复制叉上。复制应力刺激他们的招募到阻止 Filia 的 151 残余是的叉和丝氨酸以一种 ATR 依赖的方式的 phosphorylated。这修正使跳动 Filia 的建筑群能充当功能的脚手架,它然后通过双机制支持拖延的叉重启:复制叉重启蛋白质, Blm,和刺激 ATR kinase 激活的两提高的招募。在 Blm 小径,脚手架招募 E3 ubiquitin ligase, Trim25,到阻止的复制叉,并且接着, Trim25 通过 ubiquitination 在阻止的复制叉拴住并且专注 Blm。在区分的房间,到复制叉和 ATR 发信号的激活的 Trim25-Blm 建筑群的招募由于转换字符特定的跳动 Filia 的支架的缺乏是更不柔韧的。因此,我们的学习表明转换字符利用另外、唯一的规章的层高效地支持阻止的叉重启并且维持 genomic 稳定性。 | Bo Zhao Weidao Zhang Yixian Cun Jingzheng Li Yan Liu Jing Gao Hongwen Zhu Hu Zhou Rugang Zhang Ping Zheng | 2018 | Cell Research2018，28，1： | 4 |
| 2 | Determination of Lead in Human Hair by High Resolution Continuum Source Graphite Furnace Atomic Absorption Spectrometry with Microwave Digestion and Solid Sampling显示文摘 | ZHAO Lijiao RENTing ZHONG Rugang | 2012 | Analyti-cal Letters2012，45，16： | 1 |
| 3 | Determ inationof leadin human hair by high resolution continuumsource graphite furnace atom ic absorption spectrom etrywith microw ave digestion and solid sampling 显示文摘 | Zhao Lijiao Ren Ting Zhong Rugang | 2012 | Analytical Letters2012，45，16： | 1 |
| 4 | Determination of lead in human hair by high resolution continuum source graphite ftlrnace atomic absorption spectrometry with microwave digestion and solid sampling显示文摘 | ZHAO Lijiao REN Ting ZHONG Rugang | 2012 | Analytical Letters2012，45，16： | 1 |
| 5 | Determination of Lead inHuman Hair by High Resolution Continuum Source Graphite Fur-nace Atomic Absorption Spectrometry with Microwave Digestion andSolid Sampling显示文摘 | ZHAO Lijiao REN Ting ZHONG Rugang | 2012 | Analytical Letters2012，45，16： | 1 |
| 6 | Determination of Lead in Human Hair by High Resolution Continuum Source Graphite Furnace Atomic Absorption Spectrometry with Microwave Digestion and Solid Sampling显示文摘 | ZHAO Lijiao REN Ting ZHONG Rugang | 2012 | Analyti- cal Letters2012，45，16： | 1 |
| 7 | Determination of lead in hu-man hair by high resolution continuum source graphite furnace atom-ic absorption spectrometry with microwave digestion and solid sam-pling 显示文摘 | Zhao Lijiao Ren Ting Zhong Rugang | 2012 | Analytical Letters2012，45，16： | 1 |
| 8 | Mechanism of intramolecular mixed anhydride formation as intermediates in the reactions of N-phosphorylamino-acids──An MNDO research显示文摘N-phosphoryl-α-amino acids can react to form esters, peptides, phosphoryl ester-exchanged products and phosphoryl group migration products under mild conditions, which are very important in researches on arohebiont. It has been proposed that intramolecular mixed carboxylic-phosphoric anhydrides (IMCPAs) might be the common intermediates of the reactions, which are difficult to be experimentally observed because of their high activity. In this note, it has been revealed, by means of MNDO, that the IMCPAs are situated at the relatively minimal points of the potential surface and can form in a non-synchronous concerted reaction pathway that passes through a transition state with a hydrogen-bond-bridge structure. The results give a successful explanation to the structure and formation of IMCPAs and their ability to promote the various reactions mentioned above. | ZHONG Rugang 1, 2, ZHAO Yufen 1,* and DAI Qianhuan 2 1. Bioorganic Phosphorus Chemistry Laboratory, Department of Chemistry, Tsinghua University, Beijing 100022, China 2. Center for Chemistry and Bioengineering of Cancer Research, Beijing Polytec | 1998 | Chinese Science Bulletin1998，43，11： | 1 |
| 9 | Determination of Lead in Human Hair by High Resolution Continuum Source Graphite Furnace Atomic Absorption Spectrometry with Microwave Digestion and Solid Sampling 显示文摘 | ZHAO Lijiao RENTing ZHONG Rugang | 2012 | Analyti- cal Letters2012，45，16： | 1 |
| 10 | Determination of lead in human hair by high resolution continuum source graphite furnace atomic absorption spectrometry with microwave digestion and solid sampling显示文摘 | ZHAO Lijiao RENTing ZHONG Rugang | 2012 | Analytical Letters2012，45，16： | 1 |
| 11 | Determination of Lead in Human Hair by High Resolution Continuum Source Graphite Furnace Atomic Absorption Spectrometry with Microwave Digestion and Solid Sampling 显示文摘 | ZHAO Lijiao RENTing ZHONG Rugang | 2012 | Analytical Letters2012，45，16： | 1 |
| 12 | Skull bone tumor:a review of clinicopathological and neuroimaging characteristics of 426 cases at a single center显示文摘Dear Editor,Among the wide array of human neoplasms,bone and soft tissue tumors originating from the skull bone are extremely rare,making up<2%of all the musculoskeletal tumors[1].Skull bone tumors exist as a distinct entity because they include multiple subtypes,have complex regional anatomical structure,and require interdiscipli-nary therapy.According to the 2002 world health organi-zation(WHO)histological typing[2],skull bone tumors can be divided into benign,malignant,and undefined neoplastic nature tumors(UNNTs).Given the lack of literatures systematically reporting this uncommon dis-order and the small-scale sample size published studies on these tumor entities[3,4],a deeper understanding of the clinicopathological features across skull bone tumor is necessary.We,therefore,conducted this retrospective analysis on bony tumor spectrum involving the primary and secondary lesions arising from the skull to document the various types of tumors encountered,and to analyze their epidemiological characteristics,clinicopathogical features and neuroradiographic parameters. | Hailong Liu Xueying Zhang Mingshan Zhang Junping Zhang Weihai Ning Angela Yue Rugang Zhao Youliang Sun Chunjiang Yu | 2019 | Cancer Communications2019，39，1： | 0 |
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