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您的检索式：作者名="Ruilian Xu"
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| 1 | Long non-coding RNA LINC-PINT attenuates paclitaxel resistance in triple-negative breast cancer cells via targeting the RNA-binding protein NONO显示文摘The treatment of triple-negative breast cancer(TNBC)relies largely on chemotherapies.However,it is frequent that TNBC patients develop resistance to the chemotherapy drugs.Generation of drug-resistant cell lines facilitates the identification of drug resistance.Here,we established two paclitaxel(PTX)-resistant TNBC cancer cell lines using an intermittent and stepwise method and found that long non-coding RNA long intergenic non-protein-coding RNA p53-induced transcript(LINC-PINT)was significantly decreased in PTX-resistant cancer cells.Ectopic expression of LINC-PINT sensitized both PTX-resistant TNBC and wild-type TNBC to PTX.Moreover,RNA immunoprecipitation showed that LINC-PINT bound to RNA-binding protein NONO.Overexpression of LINC-PINT resulted in the degradation of NONO in a proteasome-dependent manner and vice versa.Knockdown of NONO with siRNA sensitized TNBC to PTX.We further analyzed the expression level of LINC-PINT and NONO in patient samples via online database and found that LINC-PINT and NONO may function antagonistically in all types of breast cancers.Taken together,our data illustrated a tumor suppressor role of LINC-PINT in sensitizing TNBC to chemotherapies via destabilizing NONO. | Jinghua Chen Meiqin Zhu Liqiu Zou Junxian Xia Jiacheng Huang Quantong Deng Ruilian Xu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，8： | 4 |
| 2 | Clinical characteristics and prognosis of triple-negative breast cancer显示文摘客观我们调查了临床的特征,和三元组否定的乳癌的预示的因素。130 个三元组否定的乳癌病人在临床的特征和预后上被考察的方法。所有情况是免疫组织化学决定的雌激素受体,孕酮受体,和 HER2/neu 的表示的缺乏。结果 17.1% 所有乳癌病人(774 个案例) 是三元组否定的乳癌,并且 68.9% 三元组否定的乳癌病人(91 个案例) 是绝经前的。53.8% 病人(71 个案例) 与 T2 尺寸有肿瘤,并且(52 个病人) 他们中的 39.4% 个有淋巴节点转移。没有淋巴节点转移,在有淋巴节点转移的病人的恶化的率在病人显然比那高(P = 0.001 ) 。后续的中部的时间是 63 个月。33 案例 relapsed 和 20 个病人死了。23 个病人有至少二机关转移。5 年的没有疾病、全面的幸存率是 73.8% 和 85.7% 。结论三元组否定的乳癌病人通常在治疗以后在 2 3 年里有多重远转移的高率。淋巴节点的地位是最重要的预示的因素。有淋巴节点转移的三元组否定的胸 caner 病人有差的预后。 | Hua Cao Maosheng Yan Shubin Wang Tao Zheng Ruilian Xu Yixin Chen Yajie Liu | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，8： | 2 |
| 3 | Molecular cloning and characterization of wheat calreticulin (CRT) gene involved in drought stressed responses 显示文摘 | Xiaoyun Jia Chongyi Xu Ruilian Jing | 2008 | Journal of Experimental Botany2008，59，： | 1 |
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