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您的检索式：作者名="Ruimeng Li"
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| 1 | Identification of Critical Components of Complex Product Based on Hybrid Intuitionistic Fuzzy Set and Improved Mahalanobis-Taguchi System显示文摘To avoid the decrease of system reliability due to insufficient component maintenance and the resource waste caused by excessive component maintenance,identifying the critical components of complex products is an effective way to improve the efficiency of maintenance activities.Existing studies on identifying critical components of complex products are mainly from two aspects i.e.,topological properties and functional properties,respectively.In this paper,we combine these two aspects to establish a hybrid intuitionistic fuzzy set to incorporate the different types of attribute values.Considering the mutual correlation between attributes,a combination of AHP(Analytic Hierarchy Process)and Improved Mahalanobis-Taguchi System(MTS)is used to determine the λ-Shapley fuzzy measures for attributes.Then,the λ-Shapley Choquet integral intuitionistic fuzzy TOPSIS(Technique for Order Preference by Similarity to an Ideal Solution)method is proposed for calculating the closeness degrees of components to generate their ranking order.Finally,a case study which is about the right gear of airbus 320 is taken as an example to verify the feasibility and effectiveness of this method.This novel methodology can effectively solve the critical components identification problem with different types of evaluation information and completely unknown weight information of attributes,which provides the implementation of protection measures for the system reliability of complex products. | Naiding Yang Mingzhen Zhang Fangmei Wangdu Ruimeng Li | 2021 | Journal of Systems Science and Systems Engineering2021，30，5： | 1 |
| 2 | Validation of novel hub genes and molecular mechanisms in acute lung injury using an integrative bioinformatics approach显示文摘Acute lung injury(ALI)is an inflammatory pulmonary disease that can easily develop into serious acute respiratory distress syndrome,which has high morbidity and mortality.However,the molecular mechanism of ALI remains unclear,and few molecular biomarkers for diagnosis and treatment have been identified.In this study,we aimed to identify novel molecular biomarkers using a bioinformatics approach.Gene expression data were obtained from the Gene Expression Omnibus database,co-expressed differentially expressed genes(CoDEGs)were identified using R software,and further functional enrichment analyses were conducted using the online tool Database for Annotation,Visualization,and Integrated Discovery.A protein-protein interaction network was established using the STRING database and Cytoscape software.Lipopolysaccharide(LPS)-induced ALI mouse model was constructed and verified.The hub genes were screened and validated in vivo.The transcription factors(TFs)and miRNAs associated with the hub genes were predicted using the NetworkAnalyst database.In total,71 CoDEGs were screened and found to be mainly involved in the cytokine-cytokine receptor interactions,and the tumor necrosis factor and malaria signaling pathways.Animal experiments showed that the lung injury score,bronchoalveolar lavage fluid protein concentration,and wet-to-dry weight ratio were higher in the LPS group than those in the control group.Real-time polymerase chain reaction analysis indicated that most of the hub genes such as colony-stimulating factor 2(Csf2)were overexpressed in the LPS group.A total of 20 TFs including nuclear respiratory factor 1(NRF1)and two miRNAs were predicted to be regulators of the hub genes.In summary,Csf2 may serve as a novel diagnostic and therapeutic target for ALI.NRF1 and mmu-mir-122-5p may be key regulators in the development of ALI. | Qingchun Liang Qin Zhou Jinhe Li Zhugui Chen Zhihao Zhang Ruimeng Liu Haicheng Huang Zhiyong Peng Youtan Liu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，3： | 1 |
| 3 | Hierarchical micro-nanostructures from polyoxometalates and polydopamine:Characterization,electrochemical and intrinsic peroxidase-like properties显示文摘Hybrid composite materials with hierarchical structures have attracted continuing attention for their enhanced features and various applications.The new hybrid composites XW_(9)@PDA(XW_(9) means Na_(8)H[α-PW_(9)O_(34)],Na_(10)[α-SiW_(9)O_(34)]and Na_(10)[α-GeW_(9)O_(34)];PDA means polydopamine)have been synthesized for potential sensing applications.The effect of polyoxometalates on the formation of the hybrid composites was investigated.Scanning electron microscopy(SEM)supported the obtained XW_(9)@PDA were hierarchical microsphere.By monitoring the reaction of classical peroxidase substrate o-phenylenediamine(OPD)to form yellow 2,3-diaminophenazine(DAB)in the presence of H_(2)O_(2),the peroxidase-like activity of XW_(9)@PDA was calculated.The results showed that XW_(9)@PDA still keep the peroxidase-like activity and have 505.98%,208.58%and 582.78%enhancement in intrinsic catalytic activity for PW_(9)@PDA,SiW_(9)@PDA and GeW_(9)@PDA.Among the three composites,PW_(9)@PDA showed the highest peroxidase-like activity.Therefore,PW_(9)@PDA was applicable to the colorimetric and electrochemical sensing for H_(2)O_(2). | Ruijuan Lv Xinming Zhang Ruimeng Sun Lixia Chen Yang Zhang Rongtian Sheng Ting Du Yuhan Li Yanfei Qi | 2022 | Particuology2022，20，5： | 1 |
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