| 1 | Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B显示文摘作为克积极的、形成孢子的厌氧的杆菌, Clostridium 顽固(C。顽固) 为严重、致命的 pseudomembranous 大肠炎负责,并且形成世界范围的最迫切的抗菌素抵抗威胁。流行 C。顽固全球性是联系抗菌素的腹泻的领先的原因,特别由于 hypervirulent 的出现,种类与高死亡和病态联系了的腹泻。TcdB,关键毒力因素之一由这个细菌藏匿了,通过糟糕理解的机制进入主人房间得到它的病原的效果。这里,我们报导 TcdB 细胞的受体的第一鉴定, chondroitin 硫酸盐 proteoglycan 4 (CSPG4 ) 。CSPG4 开始从屏蔽的一个整个染色体的人的 shRNAmir 图书馆被孤立,并且它的角色被证实由调停 TALEN 并且在人的房间的 CRISPR/Cas9-mediated 基因大美人。CSPG4 为对房间表面有约束力的 TcdB 是批评的,导致细胞骨架混乱和房间死亡。在 CSPG4 的 N 终点和 TcdB 的 C 终点之间的一个直接相互作用被证实,并且 CSPG4 的毒素绑定领域的可溶的肽能保护房间免受 TcdB 的行动的伤害。尤其是, CSPG4/NG2 的完全的损失减少了在没有显著地影响动物死亡的老鼠的被触发 TcdB 的 interleukin-8 正式就职。基于两个在里面 vitro 并且在 vivo 研究,我们为 TcdB endocytosis 建议一个双受体的模型。第一 TcdB 受体的发现为 CSPG4 揭示一个以前不受怀疑的角色并且为 C 的处理提供一个新治疗学的目标。顽固感染。 | Pengfei Yuan Hongmin Zhang Changzu Cai Shiyou Zhu Yuexin Zhou Xiaozhou Yang Ruina He Chan Li Shengjie Guo Shan Li Tuxiong Huang Gregorio Perez-Cordon Hanping Feng Wensheng Wei | 2015 | Cell Research2015，25，2： | 6 |
| 2 | Rock-magnetic characteristics and mechanisms of the Titel loess-paleosol sequence in northern Serbia since late Middle Pleistocene显示文摘The changing pattern of magnetic characteristics in eastern European loess deposits is the most similar across the world to that of the Chinese Loess Plateau,both of which are dominated by the strength of pedogenesis.Hence a systematical study to the rock magnetism of eastern European loess is not only helpful for understanding the paleoclimatic information preserved by themselves,but also beneficial for promoting the cognition of the pedogenic mechanism in loess records.In this study,a detailed rock-magnetic analysis of seventy loess/paleosol samples,taken from the Titel Loess Plateau in northern Serbia,is carried out for a better understanding of the magnetic records since late Middle Pleistocene.The results provide us some implications.First,the magnetic susceptibility values of the paleosols in the Titel loess-paleosol sequence are generally less than 100×10^(-8)m^(3)kg^(-1),significantly lower than those of the loess sections in the Chinese Loess Plateau,even though they are under similar climatic conditions.However,the behaviors of the parameters related to the distributions of magnetic particles in these two regions are similar.The difference in the contents of ferrimagnetic minerals is the leading reason that caused the difference in their magnetic characteristics,but the mechanism is still open to study.Second,based on the analysis of thermomagnetic curves,a gradually increasing trend of the relative contents of maghemite over the last four glacial-interglacial cycles is identified.The realization of thermally unstable maghemite from Chinese loess leads us to speculate that the long-term increasing trend of the relative contents of maghemite in Titel loess-paleosol sequence likely is a mineralogical response to the progressive enhancement of continental climate in the Pannonian Basin since the Middle Pleistocene. | Zhi LIU Xiuming LIU Slobodan B.MARKOVIC Bin LU Ruina HE | 2022 | Science China Earth Sciences2022，65，3： | 0 |
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