3篇
您的检索式：作者名="Ruining Gong"
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| 1 | Epithelial cells mimic immune cells: a novel path toward tumor immunotherapy显示文摘Recently,we have shown that FOXP3,a critical transcription factor in regulatory T cells(Tregs),is expressed in pancreatic epithelial cells,and restrain the activity of CD8+T cells by upregulating PD-L1,which in turn regulates immune escape in pancreatic ductal adenocarcinoma(PDAC)^(1).On the basis of a series of studies of our laboratory,we hypothesize that a subset of pancreatic epithelial cells mimics the phenotype and function of Tregs(named quasi-Tregs or qTregs);this concept has been supported by a peer-reviewed commentary^(2).Moreover,evidence suggests that tumor epithelial cells can mimic other types of immune cells and participate in the formation of a tumor immunosuppressive microenvironment(TIM). | Ruining Gong Yan Huang Xiaoxuan Wang Xiaobing Chen Zibin Tian He Ren | 2021 | Cancer Biology & Medicine2021，18，4： | 0 |
| 2 | Targeting chemokines/chemokine receptors:a promising strategy for enhancing the immunotherapy of pancreatic ductal adenocarcinoma显示文摘In recent study published on Nature Medicine,Bockorny et al.1 performed a single-arm phase IIa trial(COMBAT study,NCT02826486)to evaluate safety,efficacy,immunobiological changes,and potential biomarkers for the CXCR4 inhibitor BL-8040,combined with a PD-1 antagonist(pembrolizumab)as a second-line or third-line treatment for patients with metastatic PDAC.This evidence translates the theory of reprogramming tumor immunosuppressive microenvironment into clinical practice and supports that targeting chemokines/chemokine receptors facilitates the immunotherapy of pancreatic ductal adenocarcinoma(Fig.1). | Ruining Gong He Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 3 | Metabolic signatures in pancreatic ductal adenocarcinoma:diagnostic and therapeutic implications显示文摘Pancreatic ductal adenocarcinoma(PDAC)is the prototypical aggressive cancer that develops in nutrient-deficient and hypoxic microenvironment.PDAC overcomes these restrictions by employing unconventional tactics for the procurement and usage of fuel sources.The substantial reprogramming of PDAC cell metabolism is driven by oncogene-mediated cell-autonomous pathways.PDAC cells use glucose,glutamine,and lipids for energy and depend on autophagy and macropinocytosis for survival and growth.They also interact metabolically with non-cancerous cells,aiding tumor progression.Many clinical trials focusing on altered metabolism are ongoing.Understanding the metabolic regulation of PDAC cells will not only help to increase understanding of the mechanisms of disease progression but also provide insights for the development of new diagnostic and therapeutic approaches. | Ruining Gong Yonglu Hu Qian Yu Lin Fang He Ren | 2023 | Journal of Pancreatology2023，6，4： | 0 |
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