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| 1 | Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies显示文摘Background: Recent research into skin injury and wound healing has focused mainly on post‐trauma hemostasis, infection prevention, dermal regeneration and angiogenesis. However, less attention has been paid to air permeability and moisture loss prevention which also play important roles in injury healing. Methods: In the present work, we prepared a hyaluronic acid‐poloxamer (HA‐POL) hydrogel and tested the therapeutic effect of the hydrogel on skin‐wound healing. Results: The HA‐POL hydrogel transformed from sol to gel at 30°C, close to body temperature, and had stable moisturizing properties. HA‐POL hydrogel promoted skin‐wound healing and increased protein accumulation in the wound area. HA‐POL hydrogel allowed greater air permeability than Band‐aid, a typical wound covering. Results from transwell assays showed that the HA‐POL hydrogel effectively isolated skin‐wounds from bacterial invasion. Conclusion: This work demonstrates the advantages of using HA‐POL gel materials in the treatment of cutaneous wounds. | Xiaojuan Li Aimin Li Fan Feng Qiyu Jiang Huiwei Sun Yantao Chai Ruichuang Yang Zhijie Wang Jun Hou Ruisheng Li | 2019 | Animal Models and Experimental Medicine2019，2，2： | 1 |
| 2 | Research on the analysis and design of general test database management system显示文摘 | SUN Hongmei JIA Ruisheng | 2012 | Procedia engineering2012，29，： | 1 |
| 3 | Research on case teaching of software development comprehensive practice based on project driven显示文摘 | Sun Hongmei Jia Ruisheng | 2012 | Procedia Engineering2012，，29： | 1 |
| 4 | Optimal Guidance Law to Maximize Terminal Velocity for Missiles with Impact Angle Constraint显示文摘In this paper,an optimal guidance law for missiles with impact angle and miss distance constraints is proposed to achieve the maximal terminal velocity. The normal acceleration command that includes the timevarying coefficients is introduced to satisfy the desired impact angle as well as zero miss distance according to the geometric relation and relative motion parameters between missile and target. The problem is formulated as an optimal control problem by defining the angle of velocity error and flight-path angle as state variables and maximizing a performance index of the terminal velocity. The analytical form of the proposed guidance law is obtained as the solution of the optimal control problem combining optimal control theory and numerical value computation method. Nonlinear simulations of various situations demonstrate the performance and feasibility of the proposed optimal guidance law. | Chao Ming Ruisheng Sun Chuanjie Sun | 2016 | Journal of Harbin Institute of Technology(New Series)2016，23，2： | 1 |
| 5 | Quantitative examination of the inhibitory activation of molecular targeting agents in hepatocellular carcinoma patient-derived cell invasion via a novel in vivo tumor model显示文摘Background: The outcomes for patients with advanced hepatocellular carcinoma(HCC) receiving sorafenib are far from satisfactory because of treatment resistance to sorafenib. However, the exact mechanism of resistance to sorafenib remains unclear and it is valuable to establish a novel mouse model to quantitatively analyze the inhibition rates of sorafenib on the invasive growth of HCC cells in the liver.Methods: HCC tissue microblocks derived from patients were cultured and mixed with hydrogel drops. Then, hydrogel drops containing microblocks of HCC tissue were attached onto the surface of the livers of nude mice to form lesions or nodules of HCC. The mice received molecular targeting agents through oral administration. Livers with tumor nodules were harvested for H&E staining(hematoxylin-eosin staining) analysis and H&E staining images were quantitatively analyzed using image J software. The invasive growth of HCC cells into the liver was calculated using the depth of the lesions compared with the total thickness of the liver.Results: Microblocks containing cells derived from HCC patients can form lesions in the liver of nude mice. Oral administration of molecular targeting agents inhibited the invasive growth of HCC cells in the liver of nude mice.Conclusions: The model established in this study involves the invasive growth of HCC cells in the liver of nude mice, and the model allows for the quantitative analysis of the inhibitory effect of molecular targeting agents on the invasion of HCC cells in vivo. | Huiwei Sun Fan Feng Hui Xie Xiaojuan Li Qiyu Jiang Yantao Chai Zhijie Wang Ruichuang Yang Ruisheng Li Jun Hou | 2019 | Animal Models and Experimental Medicine2019，2，4： | 1 |
| 6 | Municipal Services in Guangzhou at Beginning of Republican Period | XU Ruisheng, PhD Candidate, Urban and Regional Studies Center, Sun Yat-sen University, Guangzhou, P. R. China LI Caige | 2009 | China City Planning Review2009，18，4： | 0 |
| 7 | Cooperative game penetration guidance for multiple hypersonic vehicles under safety critical framework显示文摘The rapid development of the anti-missile weapon technology brings new challenges to the cooperative penetration strategy solution and the guidance law design for Hypersonic Vehicles(HVs).This paper studies the coordinated game penetration guidance problem for multiple hypersonic vehicles faced with space threat areas.A scheme for seeking cooperative game penetration guidance strategy under safety critical control framework is presented.In this scheme,a multiHV cooperative game model is proposed in a minimum optimization form which can simplify the solving process and accelerate the computing speed.Then,a second-order control barrier function is developed to transform the implicit nonlinear constraints of the proposed model into linear ones.In order to obtain better performance of guidance strategy,a composite guidance law under the safety critical control framework is presented to allocate guidance strategies appropriately in the whole process.It is shown that the proposed scheme can guarantee successful penetration while avoiding threat areas.Finally,a comparative simulation with a two-on-three game is conducted to verify the effectiveness of the proposed method. | Jieqing CHEN Ruisheng SUN Yu LU | 2024 | Chinese Journal of Aeronautics2024，37，1： | 0 |
| 8 | Numerical study on the cavity dynamics for vertical water entries of twin spheres显示文摘In this study, a three dimensional(3D) numerical model of six-degrees-of-freedom(6DOF) is applied to simulate the water entries of twin spheres side-by-side at different lateral distances and time intervals.The turbulence structure is described using the shear-stress transport k-ω(SST k-ω) model, and the volume of fluid(VOF) method is used to track the complex air-liquid interface. The motion of spheres during water entry is simulated using an independent overset grid. The numerical model is verified by comparing the cavity evolution results from simulations and experiments. Numerical results reveal that the time interval between the twin water entries evidently affects cavity expansion and contraction behaviors in the radial direction. However, this influence is significantly weakened by increasing the lateral distance between the two spheres. In synchronous water entries, pressure is reduced on the midline of two cavities during surface closure, which is directly related to the cavity volume. The evolution of vortexes inside the two cavities is analyzed using a velocity vector field, which is affected by the lateral distance and time interval of water entries. | Xu Wang Xujian Lyu Ruisheng Sun Dongdong Tang | 2024 | Defence Technology(防务技术)2024，32，2： | 0 |
| 9 | Gain-Scheduling H_∞ Autopilot Design for Tactical Missiles with Variable-Swept Wings显示文摘A new approach to gain-scheduling of H∞controllers is proposed for a cruise missile with variableswept wings( VSW) in bank-to-turn( BTT) mode. A nonlinear dynamic model is established and anticipant performance criterions are given at first. For the selected operating points,feedback robust controllers of threechannels are designed independently to restrain cross-channel couple disturbances and aerodynamic perturbations. Then,the sweepback and Ma number are selected to schedule controller gains iteratively to ensure all closed-loop poles locating inside the desired region. The proposed method here attempts to extend the performance of initial design obtained for a single arbitrary point to the whole linearized domain while maintaining the expected stability over the entire range of sweepback and full flight envelope. Some time-domain analysis procedures based on the proposed method are carried out and assessed,while the performance of tracking and robustness to aerodynamic perturbations in different situations are contrasted by some nonlinear simulations. Finally,the numerical simulations demonstrate that the proposed autopilot design method has better tracking performance and is robust,effective and feasible. | Hongyang Bai Ruisheng Sun Weiming Li Xiulai Wang | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，1： | 0 |
| 10 | Trajectory Optimization Design for Morphing Wing Missile显示文摘This paper presents a new particle swarm optimization( PSO) algorithm to optimize the trajectory of morphing-wing missile so as to achieve the enlargement of the maximum range. Equations of motion for the twodimensional dynamics are derived by treating the missile as an ideal controllable mass point. An investigation of aerodynamic characteristics of morphing-wing missile with varying geometries is performed. After deducing the optimizing trajectory model for maximizing range,a type of discrete method is put forward for taking optimization control problem into nonlinear dynamic programming problem. The optimal trajectory is solved by using PSO algorithm and penalty function method. The simulation results suggest that morphing-wing missile has the larger range than the fixed-shape missile when launched at supersonic speed,while morphing-wing missile has no obvious range increment than the fixed-shape missile at subsonic speed. | Ruisheng Sun Chao Ming Chuanjie Sun | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，5： | 0 |
| 11 | Skeletal muscle cell apoptosis following motor nerve injury versus sensory nerve injury显示文摘Skeletal muscle atrophy inevitably occurs in denervated skeletal muscle,and cell apoptosis plays an important role in skeletal muscle atrophy and degeneration.The present study established rat models of simple nerve injury by transecting the ventral or dorsal spinal nerve root and observed rat skeletal muscle cell apoptosis following simple motor nerve injury versus simple sensory nerve injury.Following skeletal muscle denervation for 10 weeks,cell apoptosis was detected in skeletal muscle,which was accompanied by obvious changes in rat behavior and electrophysiological responses.In addition,changes in cross-sectional area and average gray-scale of motor endplates of the gastrocnemius muscle were analyzed following sciatic nerve injury and motor nerve injury.Cell nuclei in denervated skeletal muscle tissue were more densely arranged than in normal skeletal muscle tissue.Cell nuclei were most dense in the sciatic nerve injury group,followed by the motor nerve injury group and the sensory nerve injury group.Fas/FasL expression and the number of apoptotic cells increased in denervated skeletal muscle,and apoptosis-related changes were observed.These findings suggested that motor and sensory nerves provided trophic actions following skeletal muscle and motor nerve injury,resulting in a greater influence on skeletal muscle atrophy than sensory nerve injury.Therefore,reconstruction of motor nerves should be preferentially considered for treating denervation-induced skeletal muscle atrophy. | Zhao, Lei Xu, Ruisheng Jiang, Shenyang Lue, Guangming Yan, Zhiqiang Sun, Junming Wang, Ling Xue, Ye Jiang, Donglin | 2011 | Neural Regeneration Research2011，6，3： | 0 |
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