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您的检索式：作者名="Ruiying Shu"
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| 1 | Overview of lethal human coronaviruses显示文摘Coronavirus infections of multiple origins have spread to date worldwide,causing severe respiratory diseases.Seven coronaviruses that infect humans have been identified:HCoV-229E,HCoV-OC43,HCoV-NL63,HCoV-HKU1,SARS-CoV,MERS-CoV,and SARS-CoV-2.Among them,SARS-CoV and MERS-CoV caused outbreaks in 2002 and 2012,respectively.SARS-CoV-2(COVID-19)is the most recently discovered.It has created a severe worldwide outbreak beginning in late 2019,leading to date to over 4 million cases globally.Viruses are genetically simple,yet highly diverse.However,the recent outbreaks of SARS-CoV and MERS-CoV,and the ongoing outbreak of SARS-CoV-2,indicate that there remains a long way to go to identify and develop specific therapeutic treatments.Only after gaining a better understanding of their pathogenic mechanisms can we minimize viral pandemics.This paper mainly focuses on SARS-CoV,MERS-CoV,and SARS-CoV-2.Here,recent studies are summarized and reviewed,with a focus on virus–host interactions,vaccine-based and drug-targeted therapies,and the development of new approaches for clinical diagnosis and treatment. | Bin Chen Er-Kang Tian Bin He Lejin Tian Ruiying Han Shuangwen Wang Qianrong Xiang Shu Zhang Toufic El Arnaout Wei Cheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 2 | Development of the high-strength ductile ferritic alloys via regulating the intragranular and grain boundary precipitation of G-phase显示文摘A typical G-phase strengthened ferritic model alloy(1Ti:Fe-20Cr-3Ni-1Ti-3Si,wt.%)has been carefully studied using both advanced experimental(EBSD,TEM and APT)and theoretical(DFT)techniques.During the classic“solid solution and aging”process,the superfine(Fe,Ni)_(2)TiSi-L2_(1)particles densely precipitate within the ferritic grain and subsequently transform into the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase.In the meanwhile,the elemental segregation at grain boundaries and the resulting precipitation of a large amount of the(Ni,Fe)_(16)Ti_(6)Si_(7)-G phase are also observed.These nanoscale microstructural evolutions result in a remarkable increase in hardness(100-300 HV)and severe embrittlement.When the“cold rolling and aging”process is used,the brittle fracture is effectively suppressed without loss of nano-precipitation strengthening ef-fect.Superhigh yield strength of 1700 MPa with 4%elongation at break is achieved.This key improvement in mechanical properties is mainly attributed to the pre-cold rolling process which effectively avoids the dense precipitation of the G-phase at the grain boundary.These findings could shed light on the further exploration of the precipitation site via optimal processing strategies. | Mujin Yang Chao Huang Jiajia Han Haichen Wu Yilu Zhao Tao Yang Shenbao Jin Chenglei Wang Zhou Li Ruiying Shu Cuiping Wang Huanming Lu Gang Sha Xingjun Liu | 2023 | Journal of Materials Science & Technology2023，，5： | 0 |
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