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| 1 | Features of colorectal cancer in China stratified by anatomic sites:A hospital-based study conducted in university-affiliated hospitals from 2014 to 2018显示文摘Objective:The clinical and biological characteristics of colorectal cancer have been found to differ depending on the anatomic site of the cancer.However,for Chinese patients,there is limited information on the proportion of cases at each site and the related features.In this study,we explored the location,distribution and other features of colorectal cancers at each anatomic site in Chinese patients.Methods:We conducted a hospital-based study using hospitalization summary reports from 10 Peking University-affiliated hospitals from 2014 to 2018;the reports covered a total of 2,097,347 hospitalizations.Incident cases were chosen as the study population,and their epidemiological features were further analyzed.Results:A total of 20,739 colorectal cancer patients were identified.Rectum was the most common location(48.3%)of the cancer,whereas the proportions of patients with distal and proximal colon cancer were 24.5%and18.6%,respectively.Patients with rectal cancer were predominantly male and were the youngest for all anatomical sites(each P<0.001).The highest proportion of emergency admissions,the longest hospital stays and the highest hospitalization costs were found in patients with proximal colon cancer(each P<0.001).The proximal colon cancer subgroup included the highest proportions of patients with medical histories of cholecystectomy,cholecystolithiasis and/or gallbladder polyps and appendectomy(P=0.009,P<0.001 and P<0.001,respectively).The distal colon cancer subgroup included the highest proportions of patients with medical histories of diabetes and hypertension(P<0.001,respectively).Conclusions:The patterns of colorectal cancer observed in this study differ from those reported for Western patients and show a significantly higher proportion of patients with rectal cancer.Different epidemiological features were also found based on anatomic sites.Further studies based on tumor location should be conducted to facilitate more accurate screening and treatment. | Ruize Qu Yanpeng Ma Liyuan Tao Xiaoyuan Bao Xin Zhou Bingyan Wang Fei Li Siyi Lu Lin Tuo Siyan Zhan Zhipeng Zhang Wei Fu | 2021 | Chinese Journal of Cancer Research2021，33，4： | 10 |
| 2 | Task-related functional magnetic resonance imaging-based neuronavigation for the treatment of depression by individualized repetitive transcranial magnetic stimulation of the visual cortex显示文摘To determine whether repetitive transcranial magnetic stimulation(rTMS)of the visual cortex(VC)provides effective and welltolerated treatment and whether magnetic resonance imaging(MRI)measures functional change of the VC as a biomarker of therapeutic effect in major depressive disorder(MDD),we performed a sham-controlled,double-blind,randomized,three-arm VC rTMS treatment study in 74 MDD patients.Neuronavigated rTMS(10 Hz,90%of resting motor threshold,1,600 pulses over20 min twice per day)was performed over the VC for five days.Clinical outcome was measured by Hamilton Depression Rating Scale(HAMD-24)at days 0,1,3,5 and after terminating rTMS,with follow-up at four weeks.MRI was measured at days 0 and5.The individualized group exhibited the greatest change in HAMD-24 scores after VC rTMS for 5 days(F=5.53,P=0.005),which were maintained during follow-up period(F=4.22,P=0.016).All patients reported good tolerance.Changes in VC taskrelated functional MRI correlated with symptomatic reduction in the individualized group.Treatment reduced the initially abnormal increase in resting state functional connectivity from the VC to the pre/subgenual anterior cingulate cortex at day 5,especially in the individualized group.We demonstrated therapeutic potential and good tolerance of VC rTMS in MDD patients,indicated by biomarkers of f MRI measurement. | Zhijun Zhang Hongxing Zhang Chun-Ming Xie Meng Zhang Yachen Shi Ruize Song Xiang Lu Haisan Zhang Kun Li Bi Wang Yongfeng Yang Xianrui Li Jianli Zhu Yang Zhao Ti-Fei Yuan Georg Northoff | 2021 | Science China(Life Sciences)2021，64，1： | 8 |
| 3 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 4 | Comparing Land Degradation and Regeneration Trends in China Drylands显示文摘The aim of this paper is to offer a statistically sound method to make a precise account of the speed of land degradation and regeneration processes.Most common analyses of land degradation focus instead on the extent of degraded areas,rather than on the intensity of degradation processes.The study was implemented for the Potential Extent of Desertification in China(PEDC),composed by arid,semi-arid,and dry sub-humid regions and refers to the period 2002 to 2012.The metrics were standard partial regression coefficients from stepwise regressions,fitted using Net Primary Productivity as the dependent variable,and year number and aridity as predictors.The results indicate that:①the extension of degrading lands(292896 km 2 or 9.12%of PEDC)overcomes the area that is recovering(194560 km 2 or 6.06%of PEDC);and②the intensity of degrading trends is lower than that of increasing trends in three land cover types(grassland,desert,and crops)and in two aridity levels(semi-arid and dry sub-humid).Such an outcome might pinpoint restoration policies by the Chinese government,and document a possible case of hysteresis. | Gabriel Del BARRIO Zhihai GAO Jaime Martinez-VALDERRAMA Xiaosong LI Maria ESANJUAN Bin SUN Alberto RUIZ Bengyu WANG Juan PUIGDEFABREGAS | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 5 | ATP and purinergic receptor-dependent membrane traffic in bladder umbrella cells显示文摘 | Wang E C Lee J M Ruiz W G | 2005 | J Clin Invest2005，115，9： | 1 |
| 6 | Sodium hydroxide - catalyzed transfer hydrogenation of carbonyl compounds and nitroarenes using ethanol or isopropanol as both solvent and hydrogen donor 显示文摘 | Wang D Deraedt C Ruiz J | 2015 | Journal of Molecular Catalysis A: Chemical2015，400，： | 1 |
| 7 | The clicked pyridyltriazole ligand:From homogeneous to robust,recyclable heterogeneous mono-and polymetallic palladium catalysts for efficient Suzuki-Miyaura,Sonogashira,and Heck reactions显示文摘 | WANG D DENUX D RUIZ J | 2013 | Adv Synth Catal2013，355，1： | 1 |
| 8 | Graphene oxide: a non- specific enhancer of cellular growth 显示文摘 | Ruiz ON Fernando KA Wang B | 2011 | ACS Nano2011，5，10： | 1 |
| 9 | Cooperation between MoO3 and other metal oxides in selective oxidation of isobutene to methacrolein显示文摘 | Wang L T Ma S Y Ruiz P | 1990 | J Mol Catal1990，61，： | 1 |
| 10 | Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts,Caeo-2 in vitro cell culture model,and multiple human tissues显示文摘 | RUIZ D H WANG Qing COOK T J | 2001 | AAPS Pharmsei2001，3，1： | 1 |
| 11 | Graphene oxide :a non- specific enhancer of cellular growth 显示文摘 | Ruiz O N Fernsndo K A S Wang B J | 2011 | American Chemical Society2011，5，10： | 1 |
| 12 | Corrosion relationships as a function of time and surface roughness on a structural AE44 magnesium alloy显示文摘 | Roxanna B. Alvarez Holly J. Martin M.F. Horstemeyer Mei.Q. Chandler Neil Williams Paul T. Wang Augusto Ruiz | 2010 | Corrosion Science2010，，5： | 1 |
| 13 | Role of en?dothelial Nox2 NADPH oxidase in angiotensin Il -in?duced hypertension and vasomotor dysfunction显示文摘 | Murdoch CE Alom- Ruiz SP Wang M | 2011 | Basic Res Cardiol2011，106，4： | 1 |
| 14 | The late Archaean to early Proterozoic origin and evolution of anaerobic methane-oxidizing archaea显示文摘Impact statement Microorganisms,called anaerobic methane-oxidizing archaea(ANME),can reduce a large amount of greenhouse gas methane and therefore have the potential to cool the Earth.We collected nearly all ANMEs genomes in public databases and performed a comprehensive comparative genomic analysis and molecular dating.Our results show that ANMEs originated in the late Archaean to early Proterozoic eon.During this period of time,our planet Earth was experiencing the Great Oxygenation Event and Huronian Glaciation,a dramatic drop in the Earth's surface temperature.This suggests that the emergence of ANMEs may contribute to the reduction of methane at that time,which is an unappreciated potential cause that led to the Huronian Glaciation. | Yinzhao Wang Ruize Xie Jialin Hou Zhenbo Lv Liuyang Li Yaoxun Hu Hungchia Huang Fengping Wang | 2022 | mLife2022，1，1： | 1 |
| 15 | Cooperation between MoO3 and other metal oxides in selective oxidation of isobutene to methacrolein显示文摘 | Wang L T Ma S Y Ruiz P | 1990 | J Mol Catal1990，61，： | 1 |
| 16 | Spatial expression patterns of peptide transporters in the human and rat gastrointestinal tracts,Caco-2 in vitro cell culture model and multiple human tissues显示文摘 | RUIZ D H WANG Q COOK T J | 2001 | Aaps Pharmsci2001，9，： | 1 |
| 17 | Biochemical changes of fresh-cut pineapple slices treated with antibrowning agents显示文摘 | Gonzalez A G A Ruiz C S Soto V H Vazquez O F Pacheco A R Wang C Y | 2005 | International journal of food science & technology2005，40，4： | 1 |
| 18 | Studies of photorefractive crystals of double-doped Ce:Fe:LiNbO3显示文摘 | YANG Chunhui ZHAO Yeguan WANG Ruiz | 2000 | Opt Commun2000，175，： | 1 |
| 19 | Photo-refractive properties of Mg:In:Fe:LiNbO3 crystal显示文摘 | SHI Liansheng WANG Ruiz WANG Biao | 2003 | J Cryst Growth2003，256，： | 1 |
| 20 | Stretch-regulated exocy- tosis/endocytosis in bladder umbrella cells 显示文摘 | Truschel ST Wang E Ruiz WG | 2002 | Mol Biol Cell2002，13，： | 1 |
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