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| 1 | Structure reveals that BAK1 as a co-receptor recognizes the BRIl-bound brassinolide显示文摘 | Yadong Sun Zhlfu Han Jiao Tang Zehan Hu Chengliang Chai Bin Zhou Jijie Chai | 2013 | Cell Research2013，23，11： | 24 |
| 2 | Parkin promotes proteasomal degradation of p62: implication of selective vulnerability of neuronal cells in the pathogenesis of Parkinson's disease显示文摘 | Pingping Song Shanshan Li Hao Wu Ruize Gao Guanhua Rao Dongmei Wang Ziheng Chen Biao Ma Hongxia Wang Nan Sui Haiteng Deng Zhuohua Zhang Tieshan Tang Zheng Tan Zehan Han Tieyuan Lu Yushan Zhu Quan Chen | 2016 | Protein & Cell2016，7，2： | 8 |
| 3 | Structural basis for specific self-incompatibility response in Brassica显示文摘自我障碍(SI ) 是在阻止自体受精的 flowering 植物的普遍机制并且使近交。在 Brassica,高度多态的 S 地点充满半胱氨酸的蛋白质的识别(SCR;或 S 地点蛋白质 11 ) 由同样多态的 S 地点受体, kinase (SRK ) 支配 SI 特性。这里,我们从 Brassica rapa 与 SCR9 在建筑群报导 SRK9 (eSRK9 ) 的细胞外的领域的水晶结构。SCR9 绑定导致 eSRK9 homodimerization,形成 2:2 eSRK : 有象信 A 一样的形状的 SCR heterotetramer。SCR9 的特定的识别通过三超(hv ) 被调停 eSRK9 的区域。每 SCR9 同时从第二 eSRK9 单体从一 eSRK9 单体和 hvII 的另外的一半与 hvII 的 hvI 和一个一半交往,起在调停的一个主要作用没有包含在二个 SCR9 分子之间的相互作用的 SRK9 homodimerization。为 eSRK9-SCR9 相互作用批评的残余的单个变化在 vitro 破坏他们的绑定。我们的学习文饰由 SRK 的 SCR 的特定的识别上的数据的身体并且为理解在 SRK 和 SCR 之间的合作进化提供一个结构的模板。 | Rui Ma Zhifu Han Zehan Hu Guangzhong Lin Xinqi Gong Heqiao Zhang June B Nasrallah Jijie Chai | 2016 | Cell Research2016，26，12： | 3 |
| 4 | Structural basis for specific flagellin recognition by t ~ILR protein NAIP5显示文摘充满域的核苷酸绑定和包含蛋白质(NLR ) 的充满白氨酸的重复(LRR ) 作为细胞内部的有免疫力的受体工作检测导出病原体或导出主人的信号的存在。NLR 怎么察觉到他们的 ligands 的机制留下逃犯。这里,我们与 cryo 电子显微镜学在 4.28 点决定的 NLR 蛋白质 NAIP5 和 NLRC4 在建筑群报导细菌的 flagellin 衍生物的结构吗?分辨率。结构表明 flagellin 衍生物形成包括 NAIP5 的 BIR1 和 LRR 与多重领域交往的二平行 helices。对在 flagellin 衍生物的将近完全的埋葬的 NAIP5 结果有约束力,因此稳定 NAIP5 的活跃符合构造。flagellin 的极端 C 终端方面被抛锚到 NAIP5 的一个位地抑制的有约束力的衣袋,它多半由 NAIP5 为不同细菌的 flagellins 的辨别充当一个结构的决定因素,一个观点进一步由生物化学的数据支持了。一起拿,我们的结果使位于 NLR ligand 下面的分子的机制清楚些感觉。 | Xinru Yang Fan Yang Weiguang Wang Guangzhong Lin Zehan Hu Zhifu Han Yijun Qi Liman Zhang Jiawei Wang Sen-Fang Sui Jijie Chai | 2018 | Cell Research2018，28，1： | 2 |
| 5 | COVID-19 vaccine development:milestones,lessons and prospects显示文摘With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern(VOC),the implementation of vaccination is critically important.Existing SARS-CoV-2 vaccines mainly include inactivated,live attenuated,viral vector,protein subunit,RNA,DNA,and virus-like particle(VLP)vaccines.Viral vector vaccines,protein subunit vaccines,and mRNA vaccines may induce additional cellular or humoral immune regulations,including Th cell responses and germinal center responses,and form relevant memory cells,greatly improving their efficiency.However,some viral vector or mRNA vaccines may be associated with complications like thrombocytopenia and myocarditis,raising concerns about the safety of these COVID-19 vaccines.Here,we systemically assess the safety and efficacy of COVID-19 vaccines,including the possible complications and different effects on pregnant women,the elderly,people with immune diseases and acquired immunodeficiency syndrome(AIDS),transplant recipients,and cancer patients.Based on the current analysis,governments and relevant agencies are recommended to continue to advance the vaccine immunization process.Simultaneously,special attention should be paid to the health status of the vaccines,timely treatment of complications,vaccine development,and ensuring the lives and health of patients.In addition,available measures such as mix-and-match vaccination,developing new vaccines like nanoparticle vaccines,and optimizing immune adjuvant to improve vaccine safety and efficacy could be considered. | Maochen Li Han Wang Lili Tian Zehan Pang Qingkun Yang Tianqi Huang Junfen Fan Lihua Song Yigang Tong Huahao Fan | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 2 |
| 6 | Structural Basis for flg22-Induced Activation of the Arabidopsis FLS2-BAK1 Immune Complex显示文摘 | Yadong Sun Lei Li Alberto P. Macho Zhifu Han Zehan Hu Cyril Zipfel Jian-Min Zhou Jijie Chai | 2013 | Science . 2013 (6158)2013，，6158： | 1 |
| 7 | Adaptive Learning-Based Delay-Sensitive and Secure Edge-End Collaboration for Multi-Mode Low-Carbon Power IoT显示文摘Multi-mode power internet of things(PIoT)combines various communication media to provide spatio-temporal coverage for low-carbon operation in smart park.Edge-end collaboration is feasible to achieve the full utilization of heterogeneous resources and anti-eavesdropping.However,edge-end collaboration-based multi-mode PIoT faces challenges of mutual contradiction in communication and security quality of service(QoS)guarantee,inadaptability of resource management,and multi-mode access conflict.We propose an Adaptive learning based delAysensitive and seCure Edge-End Collaboration algorithm(ACE_(2))to optimize multi-mode channel selection and split device power into artificial noise(AN)transmission and data transmission for secure data delivery.ACE_(2) can achieve multi-attribute QoS guarantee,adaptive resource management and security enhancement,and access conflict elimination with the combined power of deep actor-critic(DAC),“win or learn fast(WoLF)”mechanism,and edge-end collaboration.Simulations demonstrate its superior performance in queuing delay,energy consumption,secrecy capacity,and adaptability to differentiated low-carbon services. | Haijun Liao Zehan Jia Ruiqiuyu Wang Zhenyu Zhou Fei Wang Dongsheng Han Guangyuan Xu Zhenti Wang Yan Qin | 2022 | China Communications2022，19，7： | 1 |
| 8 | Implantation of hydrogel-liposome nanoplatform inhibits glioblastoma relapse by inducing ferroptosis显示文摘Glioblastoma is acknowledged as the most aggressive cerebral tumor in adults.However,the efficacy of current standard therapy is seriously undermined by drug resistance and suppressive immune microenvironment.Ferroptosis is a recently discovered form of iron-dependent cell death that may have excellent prospect as chemosensitizer.The utilization of ferropotosis inducer Erastin could significantly mediate chemotherapy sensitization of Temozolomide and exert anti-tumor effects in glioblastoma.In this study,a combination of hydrogel-liposome nanoplatform encapsulatedwith Temozolomide and ferroptosis inducer Erastin was constructed.Theαvβ3 integrin-binding peptide cyclic RGD was utilized to modify codelivery system to achieve glioblastoma targeting strategy.As biocompatible drug reservoirs,cross-linked GelMA(gelatin methacrylamide)hydrogel and cRGD-coated liposome realized the sustained release of internal contents.In the modified intracranial tumor resection model,GelMA-liposome system achieved slow release of Temozolomide and Erastin in situ for more than 14 d.The results indicated that nanoplatform(T+E@LPs-cRGD+GelMA)improved glioblastoma sensitivity to chemotherapeutic temozolomide and exerted satisfactory anti-tumor effects.It was demonstrated that the induction of ferroptosis could be utilized as a therapeutic strategy to overcome drug resistance.Furthermore,transcriptome sequencing was conducted to reveal the underlying mechanism that the nanoplatform(T+E@LPs-cRGD+GelMA)implicated in.It is suggested that GelMA-liposome system participated in the immune response and immunomodulation of glioblastoma via interferon/PD-L1 pathway.Collectively,this study proposed a potential combinatory therapeutic strategy for glioblastoma treatment. | Zixiao Wang Zihao Liu Shan Wang Xin Bing Xiaoshuai Ji Dong He Min Han Yanbang Wei Chanyue Wang Qian Xia Jianqiao Yang Jiajia Gao Xianyong Yin Zhihai Wang Zehan Shang Jiacan Xu Tao Xin Qian Liu | 2023 | Asian Journal of Pharmaceutical Sciences2023，18，3： | 0 |
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