| 1 | Ferritin as a diagnostic, differential diagnostic, and prognostic marker for immune-related adverse events显示文摘Objective:Distinguishing immune-related adverse events(irAEs)caused by immune checkpoint inhibitors(ICIs)from the AEs caused by chemotherapy,targeted therapy,or infection is highly difficult.This study offers new insights into evaluating the diagnosis,differential diagnostic,and prognostic value of ferritin for irAEs induced by ICIs.Methods:From December 1,2018,to April 1,2019,we examined 318 patients with malignant tumors who received serum ferritin monitoring.The cohort comprised 231 patients treated with PD-1 inhibitor or combination with chemotherapy,and 87 patients treated with chemotherapy.Of the 231 patients,90 had irAEs(irAE group),70 had non-irAEs(non-irAE group),67 had no AEs(no irAE-non irAE group),and 4 had unclassified AEs.In the 87 patients,60 had AEs(AE group),and 27 had no AEs(no AE group).Statistical analyses were conducted with nonparametric Mann-Whitney tests.Results:At the onset of AEs in the irAE group,ferritin(normal range,35–150μg/L)rose to a median of 927μg/L(range,117–17,825μg/L)from 86μg/L at baseline(range,29–421μg/L)(P<0.001).Ferritin levels at the onset of AEs in the irAE group were significantly higher than those in the non-irAE group(median,81μg/L;range,32–478μg/L)(P<0.001)and the AE group(median,103μg/L;range,23–712μg/L)(P<0.001).After treatment in the irAE group,ferritin continuously decreased to a normal range in recovered patients,showed no significant changes in stable patients,and continued to rise in patients who died.Conclusions:Ferritin can be used as a diagnostic,differential diagnostic,and prognostic marker for irAEs in patients treated with ICIs. | Weihong Zhang Yuan Meng Lin Yang Meng Shen Li Zhou Runmei Li Yang Wang Weijiao Du Yanjuan Xiong Ying Han Xinwei Zhang Liang Liu Xiubao Ren | 2021 | Cancer Biology & Medicine2021，18，4： | 4 |
| 2 | Abrin P2 suppresses proliferation and induces apoptosis of colon cancer cells via mitochondrial membrane depolarization and caspase activation显示文摘在人的结肠癌 HCT-8 房间上探索 abrin P2 的细胞毒素的机制, abrin P2 从 Abrus precatorius L 的种子被孤立。abrin P2 向 12 根不同人的癌症房间线展出了 cytotoxicity,这被发现。我们的结果证明 abrin P2 压制了人的结肠癌房间(HCT-8 房间) 的增长并且在 S 和 G2/M 阶段导致了房间周期拘捕。abrin P2 由禁止了房间增长的机制经由 cyclin B1 的下面规定,增殖房间原子抗原和 Ki67,以及 P21 的起来规定。另外, abrin P2 处于 HCT-8 房间 apoptosis 的率导致了剂量依赖者和时间依赖者增加。有 Z-VAD-FMK,一个用途广泛的 caspase 禁止者,和 abrin P2 的治疗证明 abrin P2 经由 caspases 的激活导致了 HCT-8 房间 apoptosis。一起,我们的结果揭示了那 abrin 在 HCT-8 房间的导致 P2 的 apoptosis 与 caspases-3/-8/-9,在 Bcl-2/Bax 比率的减小, mitochondrial 膜潜力的损失,和细胞色素 c 的增加的激活被联系版本。我们进一步证明 abrin P2 管理有效地在裸体老鼠压制了结肠癌异种皮移植的生长。这是 abrin P2 有效地由压制增长并且导致 apoptosis 在 vivo 并且在 vitro 禁止结肠癌细胞生长的第一份报告。 | Ying Yu Runmei Yang Xiuyun Zhao Dandan Qin Zhaoyang Liu Fang Liu Xin Song Liqin Li Renqing Feng Nannan Gao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，5： | 0 |
| 3 | Diffusive gradients in thin films(DGT) probe for effectively sampling of per-and polyfluoroalkyl substances in waters and sediments显示文摘The passive sampling technique, diffusive gradients in thin films(DGT) has attracted increasing interests as an in-situ sampler for organic contaminants including per-and polyfluoroalkyl substances(PFAS). However, its effectiveness has been questioned because of the small effective sampling area(3.1 cm^(2)). In this study, we developed a DGT probe for rapid sampling of eight PFAS in waters and applied it to a water-sediment system. It has a much larger sampling area(27 cm^(2)) and as a result lower method quantification limits(0.15 –0.21 ng/L for one-day deployment and 0.02 – 0.03 ng/L for one-week deployment) and much higher(by > 10 factors) sampling rate(100 m L/day) compared to the standard DGT(piston configuration). The sampler could linearly accumulate PFAS from wastewater, was sensitive enough even for a 24 hr deployment with performance comparable to grab sampling(500m L). The DGT probe provided homogeneous sampling performance along the large exposure area. The use of the probe to investigate distributions of dissolved PFAS around the sediment-water interface was demonstrated. This work, for the first time, demonstrated that the DGT probe is a promising monitoring tool for trace levels of PFAS and a research tool for studying their distribution, migration, and fate in aquatic environments including the sediment-water interface. | Yuanyuan Yang Sisi Liu Runmei Wang Cailin Li Jianhui Tang Tao Chen Guang-Guo Ying Chang-Er Chen | 2022 | Journal of Environmental Sciences2022，34，11： | 0 |
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