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| 1 | Effect of dexamethasone on intelligence and hearing in preterm infants: a meta-analysis显示文摘OBJECTIVE: A meta-analysis of published randomized controlled trials investigating the longterm effect of dexamethasone on the nervous system of preterm infants.DATA SOURCES: Online literature retrieval was conducted using The Cochrane Library(from January 1993 to June 2013), EMBASE(from January 1980 to June 2013), MEDLINE(from January 1963 to June 2013), OVID(from January 1993 to June 2013), Springer(from January 1994 to June 2013) and Chinese Academic Journal Full-text Database(from January 1994 to June 2013). Key words were preterm infants and dexamethasone in English and Chinese.STUDY SELECTION: Selected studies were randomized controlled trials assessing the effect of intravenous dexamethasone in preterm infants. The quality of the included papers was evaluated and those without the development of the nervous system and animal experiments were excluded. Quality assessment was performed through bias risk evaluation in accordance with Cochrane Handbook 5.1.0 software in the Cochrane Collaboration. The homogeneous studies were analyzed and compared using Revman 5.2.6 software, and then effect model was selected and analyzed. Those papers failed to be included in the meta-analysis were subjected to descriptive analysis.MAIN OUTCOME MEASURES: Nervous system injury in preterm infants.RESULTS: Ten randomized controlled trials were screened, involving 1,038 subjects. Among them 512 cases received dexamethasone treatment while 526 cases served as placebo control group and blank control group. Meta-analysis results showed that the incidence of cerebral palsy, visual impairment and hearing loss in preterm infants after dexamethasone treatment within 7 days after birth was similar to that in the control group(RR = 1.47, 95%CI: 0.97–2.21; RR = 1.46, 95%CI: 0.97–2.20; RR = 0.80, 95%CI: 0.54–1.18; P > 0.05), but intelligence quotient was significantly decreased compared with the control group(MD =-3.55, 95%CI:-6.59 to-0.51; P = 0.02). Prete rm infants treated with dexamethasone 7 days after birth demonstrated an incidence of cerebral palsy and visual impairment, and changes in intelligence quotient similar to those in the control group(RR = 1.26, 95%CI: 0.89–1.79; RR = 1.37, 95%CI: 0.73–2.59; RR = 0.53, 95%CI: 0.32–0.89; RR = 1.66, 95%CI:-4.7 to 8.01; P > 0.05). However, the incidence of hearing loss was significantly increased compared with that in the control group(RR = 0.53, 95%CI: 0.32–0.89; P = 0.02).CONCLUSION: Dexamethasone may affect the intelligence of preterm infants in the early stages after birth, but may lead to hearing impairment at later stages after birth. More reliable conclusions should be made through large-size, multi-center, well-designed randomized controlled trials. | Ruolin Zhang Tao Bo Li Shen Senlin Luo Jian Li | 2014 | Neural Regeneration Research2014，9，6： | 3 |
| 2 | Intestinal microbiota dysbiosis and liver metabolomic changes during brain death显示文摘Background Whether a causative link exists between brain death(BD)and intestinal microbiota dysbiosis is unclear,and the distortion in liver metabolism associated with BD requires further exploration.Methods A rat model of BD was constructed and sustained for 9 h(BD group,n=6).The sham group(n=6)underwent the same procedures,but the catheter was inserted into the epidural space without ballooning.Intestinal contents and portal vein plasma were collected for microbiota sequencing and microbial metabolite detection.Liver tissue was resected to investigate metabolic alterations,and the results were compared with those of a sham group.Resultsα-diversity indexes showed that BD did not alter bacterial diversity.Microbiota dysbiosis occurred after 9 h of BD.At the family level,Peptostreptococcaceae and Bacteroidaceae were both decreased in the BD group.At the genus level,Romboutsia,Bacteroides,Erysipelotrichaceae_UCG_004,Faecalibacterium,and Barnesiella were enriched in the sham group,whereas Ruminococcaceae_UCG_007,Lachnospiraceae_ND3007_group,and Papillibacter were enriched in the BD group.Short-chain fatty acids,bile acids,and 132 other microbial metabolites remained unchanged in both the intestinal contents and portal vein plasma of the BD group.BD caused alterations in 65 metabolites in the liver,of which,carbohydrates,amino acids,and organic acids accounted for 64.6%.Additionally,80.0%of the differential metabolites were decreased in the BD group livers.Galactose metabolism was the most significant metabolic pathway in the BD group.Conclusions BD resulted in microbiota dysbiosis in rats;however,this dysbiosis did not alter microbial metabolites.Deterioration in liver metabolic function during extended periods of BD may reflect a continuous worsening in energy deficiency. | Ruolin Tao Wenzhi Guo Tao Li Yong Wang Panliang Wang | 2023 | Journal of Intensive Medicine2023，3，4： | 0 |
| 3 | Isotopic fingerprinting of dissolved iron sources in the deep western Pacific since the late Miocene显示文摘Iron(Fe)is a productivity-limiting nutrient in the ocean.However,the sources of dissolved Fe(dFe)in the deep ocean and how they respond to tectonic and climate changes are still poorly understood.In the northern hemisphere,dust flux to the low-latitude western Pacific has increased dramatically since the late Miocene associated with intense aridification of the Asian inland.Meanwhile,the terrigenous material supply to the open ocean might have also changed as a result of the reorganization of the Pacific circulation due to the gradual closure of seaways in the low latitudes.Therefore,the western Pacific is a characteristic region for understanding the sources of dFe in the deep ocean and their responses to long term climate changes.Here,we present data on isotopic evolution of dFe and dissolved Pb since^8 Ma based on ferromanganese crust METG-03(16.0°N,152.0°E,3850 m water depth)in the western Pacific deep water.Our results show thatδ56Fe of the crust remains fairly stable since the late Miocene,i.e.,about-0.32±0.08‰(2SD).We infer thatδ56Fe of dFe in the deep western Pacific is relatively invariant at^0.45±0.1‰based on the Fe isotopic fractionation between hydrogenetic crust and the seawater dissolved component.The reconstructed isotope signature is similar to the measuredδ56Fe value(0.37±0.15‰)of the intermediate to deep waters in the modern low-latitude western Pacific region close to the island arcs,but is significantly higher than that of the eastern Pacific deep waters near South America which is controlled by the reductive dissolution of continental shelf sediments and the hydrothermal inputs(δ56Fe<-0.1‰).The deep-water 206Pb/204Pb ratio recorded by METG-03 displays systematic increase at about 8–4 Ma,reflecting increased input from sediment dissolution of low-latitude island arcs associated with reorganization of the western Pacific deep circulation.Notably,Fe isotopes of terrigenous materials from different sources are similar,while their dissolved Fe isotopic signatures released to the ocean are mainly controlled by the mechanism of particle dissolution.The stability ofδ56Fe and systematic changes in Pb isotopes over the last^8 Ma thus suggest that Asian dust dissolution and hydrothermal inputs are likely only minor sources of dFe in the low-latitude deep western Pacific,while the acquisition and transport of dFe from shelf sediments by organic ligand binding in the oxic environment is the major dFe source which keeps stable on tectonic time scales since the late Miocene. | Ruolin LIU Bai GUO Maoyu WANG Weiqiang LI Tao YANG Hongfei LING Tianyu CHEN | 2020 | Science China Earth Sciences2020，63，11： | 0 |
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