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| 1 | Paving the Way to Smart Micro Energy Grid:Concepts,Design Principles,and Engineering Practices显示文摘The interconnection between initially independent energy infrastructures offers additional system flexibility and efficiency.The integration at distribution level simplifies the implementation of the integrated energy system functionalities.This paper proposes concepts and design principles of a smart micro energy grid(MEG)for accommodating micro-grids,distributed poly-generation systems,energy storage facilities,and associated energy distribution infrastructures.The energy management system is responsible for the smart operation of the MEG while supporting multiple criteria,such as safety,economy,and environmental protection.To realize the vision of the smart MEG,an engineering game theory based energy management system with self-approaching-optimum capability is investigated.Based on the proposed concepts,design principles,and energy management system,this paper presents a prototype of China’s first conceptual solar-based smart MEG,established in Qinghai University. | Shengwei Mei Rui Li Xiaodai Xue Ying Chen Qiang Lu Xiaotao Chen Carsten D.Ahrens Ruomei Li Laijun Chen | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 14 |
| 2 | An antibody against Siglec-15 promotes bone formation and fracture healing by increasing TRAP^(+)mononuclear cells and PDGF-BB secretion显示文摘Osteoporosis(OP)is a common age-related disease characterized by a deterioration of bone mass and structure that predisposes patients to fragility fractures.Pharmaceutical therapies that promote anabolic bone formation in OP patients and OP-induced fracture are needed.We investigated whether a neutralizing antibody against Siglec-15 can simultaneously inhibit bone resorption and stimulate bone formation.We found that the multinucleation of osteoclasts was inhibited in SIGLEC-15 conditional knockout mice and mice undergoing Siglec-15 neutralizing antibody treatment.The secretion of platelet-derived growth factor-BB(PDGF-BB),the number of tartrate-resistant acid phosphatase-positive(TRAP+)mononuclear cells,and bone formation were significantly increased in the SIGLEC-15 conditional knockout mice and antibody-treated mice.The anabolic effect of the Siglec-15 neutralizing antibody on bone formation was blunted in mice with Pdgfb deleted in TRAP-1'cells.These findings showed that the anabolic effect of the Siglec-15 neutralizing antibody was mediated by elevating PDGF-BB production of TRAP4 mononuclear cells.To test the therapeutic potential of the Siglec-15 neutralizing antibody,we injected the antibody in an ovariectomy-induced osteoporotic mouse model,which mimics postmenopausal osteoporosis in women,and in two fracture healing models because fracture is the most serious health consequence of osteoporosis.The Siglec-15 neutralizing antibody effectively reduced bone resorption and stimulated bone formation in estrogen deficiency-induced osteoporosis.Of note,the Siglec-15 neutralizing antibody promoted intramembranous and endochondral ossification at the damaged area of cortical bone in fracture healing mouse models.Thus,the Siglec-15 neutralizing antibody shows significant translational potential as a novel therapy for OP and bone fracture. | Gehua Zhen Yang Dan Ruomei Wang Ce Dou Qiaoyue Guo Melissa Zarr Linda N.Liu Lieping Chen Ruoxian Deng Yusheng Li Zengwu Shao Xu Cao | 2021 | Bone Research2021，9，4： | 6 |
| 3 | Measurement Study on Wind Characteristics of Typhoon Kalmaegi on the Sutong Bridge显示文摘The Sutong Bridge, a cable-stayed located in the southeast coastal area of China, is vulnerable to the Pacific typhoons. From the data measured by two 3D ultrasonic anemometers at the height of 76 m and 306 m, the wind characteristics (including 10-minute mean wind speed and direction, turbulence intensity and gust factor, power spectral density and integral scale of turbulence) of Typhoon Kalmaegi are analyzed The comparison of 10-minute mean wind velocity from the two anemometers validates the reliability of wind data. The turbulence intensities (Iu, Iv, and Iw) show the decreasing trend as the mean wind speed in-creases. The mean value of Iv/Iu is 0.94, while that of Iw/Iu is 0.90. Discrepancy exists between field-measured power spectra and code-suggested spectra. Those results can enlarge the wind database of the southeast coastal area of China, and provide references for wind resistance evaluation of the bridge. | HU Ruomei, WANG Hao, LI Aiqun School of Civil Engineering, Southeast University, Nanjing 210096, Jiangsu, China | 2010 | Wuhan University Journal of Natural Sciences2010，15，2： | 2 |
| 4 | Estimation of spectral responses and chlorophyll based on growth stage effects explored by machine learning methods显示文摘Estimation of leaf chlorophyll content(LCC) by proximal sensing is an important tool for photosynthesis evaluation in high-throughput phenotyping. The temporal variability of crop biochemical properties and canopy structure across different growth stages has great impacts on wheat LCC estimation, known as growth stage effects. It will result in the heterogeneity of crop canopy at different growth stages, which would mask subtle spectral response of biochemistry variations. This study aims to explore spectral responses on the growth stage effects and establish LCC models suited for different growth stages. A total number of 864 pairwise samples of wheat canopy spectra and LCC values with 216 observations of each stage were sampled at the tillering, jointing, booting and heading stages in 2021. Firstly, statistical analysis of LCC and spectral response presented different distribution traits and typical spectral variations peak at 470, 520 and 680 nm. Correlation analysis between LCC and reflectance showed typical red edge shifts. Secondly, the testing model of partial least square(PLS) established by the entire datasets to validate the predictive performance at each stage yielded poor LCC estimation accuracy. The spectral wavelengths of red edge(RE) and blue edge(BE) shifts and the poor estimation capability motivated us to further explore the growth stage effects by establishing LCC models at respective growth periods.Finally, competitive adaptive reweighted sampling PLS(CARS-PLS), decision tree(DT) and random forest(RF) were used to select sensitive bands and establish LCC models at specific stages. Bayes optimisation was used to tune the hyperparameters of DT and RF regression. The modelling results indicated that CARS-PLS and DT did not extract specific wavelengths that could decrease the influences of growth stage effects. From the RF out-of-bag(OOB) evaluation, the sensitive wavelengths displayed consistent spectral shifts from BE to GP and from RE to RV from tillering to heading stages. Compared with CARS-PLS and DT,results of RF modelling yielded an estimation accuracy with deviation to performance(RPD) of 2.11, 2.02,3.21 and 3.02, which can accommodate the growth stage effects. Thus, this study explores spectral response on growth stage effects and provides models for chlorophyll content estimation to satisfy the requirement of high-throughput phenotyping. | Dehua Gao Lang Qiao Lulu An Ruomei Zhao Hong Sun Minzan Li Weijie Tang Nan Wang | 2022 | The Crop Journal2022，10，5： | 2 |
| 5 | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets显示文摘 | Xueqing Liu Yan Yan Li Bao Beidong Chen Yanyang Zhao Ruomei Qi | 2014 | Thrombosis Research2014，，5： | 1 |
| 6 | Accurate Stress Analysis on Steel Box Girder of Long Span Suspension Bridges Based on Multi-Scale Submodeling Method显示文摘 | Hao Wang Aiqun Li Ruomei Hu Jian Li | 2010 | Advances in Structural Engineering2010，，4： | 1 |
| 7 | Comparison of ambient vibration response of the runyang suspension bridge under skew winds with time-domain numerical predictions显示文摘 | Wang Hao Li Aiqun Hu Ruomei | 2011 | Journal of Bridge Engineering ASCE2011，16，4： | 1 |
| 8 | A review and compre- hensive comparison of image denoising algorithm 显示文摘 | Shao Ling Yan Ruomei Li Xuelong | 2014 | IEEE Transactions on Cybernetics2014，44，7： | 1 |
| 9 | P-smart-a virtual system for clothing thermal functional design显示文摘 | LI Yi MAO Aihua WANG Ruomei | 2006 | Computer-Aided Design2006，38，： | 1 |
| 10 | Rational recurrence curves and recurrence surfaces in multivariate B-form onsome regions 显示文摘 | Wang Ruomei Li Yi You Fang Luo Xiaonan | 2004 | Journal of Computational and Applied Mathematics2004，163，： | 1 |
| 11 | Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1显示文摘Osteoarthritis(OA)is a prevalent joint disease with no effective treatment strategies.Aberrant mechanical stimuli was demonstrated to be an essential factor for OA pathogenesis.Although multiple studies have detected potential regulatory mechanisms underlying OA and have concentrated on developing novel treatment strategies,the epigenetic control of OA remains unclear.Histone demethylase JMJD3 has been reported to mediate multiple physiological and pathological processes,including cell differentiation,proliferation,autophagy,and apoptosis.However,the regulation of JMJD3 in aberrant force-related OA and its mediatory effect on disease progression are still unknown.In this work,we confirmed the upregulation of JMJD3 in aberrant forceinduced cartilage injury in vitro and in vivo.Functionally,inhibition of JMJD3 by its inhibitor,GSK-J4,or downregulation of JMJD3 by adenovirus infection of sh-JMJD3 could alleviate the aberrant force-induced chondrocyte injury.Mechanistic investigation illustrated that aberrant force induces JMJD3 expression and then demethylates H3K27me3 at the NR4A1 promoter to promote its expression.Further experiments indicated that NR4A1 can regulate chondrocyte apoptosis,cartilage degeneration,extracellular matrix degradation,and inflammatory responses.In vivo,anterior cruciate ligament transection(ACLT)was performed to construct an OA model,and the therapeutic effect of GSK-J4 was validated.More importantly,we adopted a peptide-si RNA nanoplatform to deliver si-JMJD3 into articular cartilage,and the severity of joint degeneration was remarkably mitigated.Taken together,our findings demonstrated that JMJD3 is flow-responsive and epigenetically regulates OA progression.Our work provides evidences for JMJD3 inhibition as an innovative epigenetic therapy approach for joint diseases by utilizing p5RHH-si RNA nanocomplexes. | Yu Jin Zhen Liu Zhenxia Li Hairui Li Cheng Zhu Ruomei Li Ting Zhou Bing Fang | 2022 | International Journal of Oral Science2022，14，3： | 1 |
| 12 | A GIS-based analytical framework for evaluating the effect of COVID-19 on the restaurant industry with big data显示文摘COVID-19 cripples the restaurant industry as a crucial socioeconomic sector that contributes immensely to the global economy.However,what the current literature less explored is to quantify the effect of COVID-19 on restaurant visitation and revenue at different spatial scales,as well as its relationship with the neighborhood character-istics of customers’origins.Based on the Point of Interest(POI)measures derived from SafeGraph data providing mobility records of 45 million cell phone users in the US,our study takes Lower Manhattan,New York City,as the pilot study,and aims to examine 1)the change of restaurant visitations and revenue in the period prior to and after the COVID-19 outbreak,2)the areas where restaurant customers live,and 3)the association between the neighborhood characteristics of these areas and lost customers.By doing so,we provide a geographic information system-based analytical frame-work integrating the big data mining,web crawling techniques,and spatial-economic modelling.Our analytical framework can be implemented to estimate the broader effect of COVID-19 on other industries and can be augmented in a financially monitoring manner in response to future pandemics or public emergencies. | Siqin Wang Ruomei Wang Xiao Huang Zhenlong Li Shuming Bao | 2023 | Big Earth Data2023，7，1： | 1 |
| 13 | A rare case of visceral leishmaniasis misdiagnosed as systemic lupus erythematosus显示文摘Visceral leishmaniasis(VL)is an infectious disease caused by Leishmania donovani and transmitted by sandflies.It can be life-threatening if not treated.Common clinical features of VL include recurrent fever,pancytopenia,splenomegaly,and a variety of positive autoantibodies,which can lead to a misdiagnosis of systemic lupus erythematosus(SLE).We report the case of a 25-year-old woman with VL misdiagnosed as SLE to add to the existing literature on this subject. | Mai Zheng Shuang Liu Xiangyu Wang XingJun Li Nan Wang Yulong Guo Jingyi Yang Bibhuti Upreti Ruomei Cui Jian Xu | 2021 | Rheumatology & Autoimmunity2021，1，1： | 0 |
| 14 | Association between HLA-B and HLA-DRB1 polymorphisms and systemic lupus erythematosus in Han population in China显示文摘We explored the association between HLA-B and HLA-DRB1 polymorphisms and reviewed clinical characteristics of systemic lupus erythematosus(SLE)in Han population in Yunnan,China.Methods:There were 295 patients and 265 healthy control subjects(HCs)enrolled in the study.Clinical data and blood samples were collected from the patients.The HLA-B and HLA-DRB1 genotypes were detected in SLE patients and HCs.Results:A total of 74 genotypes on HLA-B loci were determined in 288 patients as well as 57 genotypes in 265 HCs.The results showed SLE was associated with the HLA-B*40:01 and HLA-DRB1*08:03 alleles,and the HLAB*46:01,HLA-DRB1*12:02,DRB1*04:03,DRB1*14:01,DRB1*04:06,and DRB1*11:01 alleles were less likely to appear in SLE patients.Additionally,HLA-B*07:02 and B*40:06 were associated with disease activity.HLADRB1*03:01,DRB1*13:02,and DRB1*12:01 were associated with proteinuria.Furthermore,HLA-B*51:01,B*13:02,B*38:02,B*35:01,HLA-DRB1*15:02,DRB1*15:04,DRB1*15:01,and DRB1*08:03 were correlated with inflammatory factors and immune dysfunction.HLA-B*15:25 was related to the production of multiple antibodies.HLA-DRB1*12:02 might be a protective factor for pancytopenia.The haplotype of HLA-B*40:01/DRB1*08:03 was linked with SLE.Conclusion:SLE in Han population in Yunnan province was associated with the HLA-B*40:01 and HLA-DRB1*08:03 alleles,and the haplotype HLAB*40:01/DRB1*08:03.Several alleles were associated with inflammation,immune disorders,and organ involvement in SLE.Those alleles might be potential genetic markers of SLE. | Xiangyu Wang Yifan Yang Bibhuti Upreti Shuang Liu Ruomei Cui Yuqi Cheng Li Tao Jing Dong Luqiong Li Jian Xu | 2022 | Rheumatology & Autoimmunity2022，2，1： | 0 |
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