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| 1 | Diagnostic dilemma of abdominal tuberculosis in non-HIV patients:An ongoing challenge for physicians显示文摘AIM: To assess the clinical features, yield of the diagnostic tests and outcome of abdominal tuberculosis in non-HIV patients. METHODS: Adult patients with discharge diagnosis of abdominal tuberculosis (based upon; positive microbiology, histo-pathology, imaging or response to trial of anti TB drugs) during the period 1999 to 2004 were analyzed. Patient’s characteristics, laboratory investigations, radiological, endoscopic and surgical findings were evaluated. Abdominal site involved (intestinal, peritoneal, visceral, and nodal) and response to treatment was also noted. RESULTS: There were 209 patients enrolled. One hundred and twenty-three (59%) were females. Symptoms were abdominal pain 194 (93%), fever 134 (64%), night sweats 99 (48%), weight loss 98 (47%), vomiting 75 (36%), ascites 74 (35%), constipation 64 (31%), and diarrhea 25 (12%). Sub-acute and acute intestinal obstruction was seen in 28 (13%) and 12 (11%) respectively. Radiological evidence of pulmonary tuberculosis was found in 134 (64%) patients. Basis of diagnosis of abdominal tuberculosis were radiology (Chest and barium X-Rays, Ultrasound and CT scan abdomen) in 111 (53%) and histo-pathology (tissue obtained during surgery, colonoscopy, CT or ultrasound guided biopsy, laparoscopy and upper gastro intestinal endoscopy) in 87 (42%) patients. Mycobacterium culture was positive in 6/87 (7%) patients and response to therapeutic trial of anti tubercular drugs was the basis of diagnosis in 5 (2.3%) patients. Predominant site of involvement by abdominal TB was intestinal in 103 (49%) patients, peritoneal in 87 (42%) patients, solid viscera in 10 (5%) and nodal in 9 (4%) patients. Response to medical treatment was found in 158 (76%) patients andadditionally 35 (17%) patients also underwent surgery. In a 425 ± 120 d follow-up period 12 patients died (eight post operative) and no case of relapse was noted. CONCLUSION: Abdominal TB has diverse and non- specific symptomatology. No single test is adequate for diagnosis of abdominal tuberculosis in all patients. Abdominal TB in non-HIV patients remains an ongoing diagnostic dilemma requiring a high index of clinical suspicion. | Rustam Khan Shahab Abid Wasim Jafri Zaigham Abbas Khalid Hameed Zubair Ahmad | 2006 | World Journal of Gastroenterology2006，12，39： | 17 |
| 2 | Predictive factors for early aspiration in liver abscess显示文摘AIM: To determine the predictive factors for early aspiration in liver abscess. METHODS: A retrospective analysis of all patients with liver abscess from 1995 to 2004 was performed. Abscess was diagnosed as amebic in 661 (68%) patients, pyogenic in 200 (21%), indeterminate in 73 (8%) and mixed in 32 (3%). Multiple logistic regression analysis was performed to determine predictive factors for aspiration of liver abscess. RESULTS: A total of 966 patients, 738 (76%) male, mean age 43 ± 17 years, were evaluated: 540 patients responded to medical therapy while adjunctive percutaneous aspiration was performed in 426 patients. Predictive factors for aspiration of liver abscess were: age ≥ 55 years, size of abscess ≥ 5 cm, involvement of both lobes of the liver and duration of symptoms ≥ 7 d. Hospital stay in the aspiration group was relatively longer than in the non aspiration group. Twelve patients died in the aspiration group and this mortality was not statistically significant when compared to the non aspiration group. CONCLUSION: Patients with advanced age, abscess size > 5 cm, both lobes of the liver involvement and duration of symptoms > 7 d were likely to undergo aspiration of the liver abscess, regardless of etiology. | Rustam Khan Saeed Hamid Shahab Abid Wasim Jafri Zaigham Abbas Mohammed Islam Hasnain Shan Shaalan Beg | 2008 | World Journal of Gastroenterology2008，14，13： | 8 |
| 3 | Regolith thickness modeling using a GIS approach for landslide distribution analysis, NW Himalayas显示文摘Regolith thickness is considered as a contributing factor for the occurrence of landslides.Although, mostly it is ignored because of complex nature and as it requires more time and resources for investigation. This study aimed to appraise the role of regolith thickness on landslide distribution in the Muzaffarabad and surrounding areas, NW Himalayas.For this purpose regolith thickness samples were evenly collected from all the lithological units at representative sites within different slope and elevation classes in the field. Topographic attributes(slope, aspect, drainage, Topographic Wetness Index,elevation and curvature) were derived from the Digital Elevation Model(DEM)(12.5 m resolution).Arc GIS Model Builder was used to develop the regolith thickness model. Stepwise regression technique was used to explore the spatial variation of regolith thickness using topographic attributes and lithological units. The derived model explains about 88% regolith thickness variation. The model was validated and shows good agreement(70%) between observed and predicted values. Subsequently, the derived regolith model was used to understand the relationship between regolith thickness and landslide distribution. The analysis shows that most of the landslides were located within 1-5 m regolith thickness. However, landslide concentration is highest within 5-10 m regolith thickness, which shows that regolith thickness played a significant role for the occurrence of landslide in the studied area. | Muhammad BASHARAT Masood QASIM Muhammad SHAFIQUE Nasir HAMEED Muhammad Tayyib RIAZ Muhammad Rustam KHAN | 2018 | Journal of Mountain Science2018，15，11： | 2 |
| 4 | Helicobacter pylori outer membrane protein Q genotypes and their susceptibility to antiadhesive phytotherapeutic agents显示文摘OBJECTIVE: Helicobacter pylori is a Gram-negative organism. Its outer membrane protein Q(Hop Q) mediates host-pathogen interactions; Hop Q genotypes 1 and 2 are found associating with gastroduodenal pathologies. The authors measured the anti-adhesion effects of the extracts of Abelmoschus esculentus, Zingiber officinale, Trachyspermum ammi, Glycyrrhiza glabra, Curcuma longa and Capsicum annum against Hop Q genotypes and H. pylori cytotoxin-associated gene A(Cag A).METHODS: DNA was extracted by polymerase chain reaction of the Hop Q genotypes(i.e., type 1, type 2 and Cag A) from 115 H. pylori strains. The effect of the extracts from selected dietary ingredients was determined using a gastric adenocarcinoma cell line and a quantitative DNA fragmentation assay. The anti-adhesive effect of these extracts on H. pylori was tested using an anti-adhesion analysis.RESULTS: C. annum, C. longa and A. esculentus showed prominent anti-adhesion effects with resultant values of 17.3% ± 2.9%, 14.6% ± 3.7%, 13.8% ± 3.6%, respectively, against Hop Q type 1 and 13.1% ± 1.7%, 12.1% ± 2%, 11.1% ± 1.6%, respectively, against Hop Q type 2. C. longa(93%), C. annum(89%) and A. esculentus(75%) had better anti-adhesive activity against H. pylori with Hop Q type 1 compared to Hop Q type 2 with respective values of 70%, 64% and 51%. Extracts of C. annum(14.7% ± 4.1%), A. esculentus(12.3% ± 4.1%) and Z. officinale(8.4% ± 2.8%) had an anti-adhesion effect against Cag A-positive H. pylori strains compared to Cag A-negative strains. | Javed Yakoob Zaigham Abbas Malik Hassan Mehmood Kanwal Tariq Saima Azhar Saleem Safia Awan Abdul Malik Saeed Hamid Rustam Khan Wasim Jafri | 2017 | Journal of Integrative Medicine2017，15，5： | 0 |
| 5 | Tectonic Study of the Sub-Himalayas Based on Geophysical Data in Azad Jammu and Kashmir and Northern Pakistan显示文摘The tectonic study based on geophysical data has been carried out in Sub-Himalayas in Azad Jammu and Kashmir and northern Pakistan. A series of thin skinned and thick skinned faults have been delineated in the investigated area on the basis of present study. In the study area compressional stresses caused by the collisional of Indian and Eurasian plates developed the northwestsoutheast trending faults which are Shaheed Gala thrust, Bagh basement fault, Kashmir boundary thrust and Kawai fault or Indus Kohistan seismic zone. The crustal thickness increases towards north due to the stacking of the thrust sheets along these faults. The Murree Formation thrusts over the Siwaliks molasse along the Shaheed Gala thrust. This fault dips at an angle of 43o northeast and joins the thick skinned Bagh basement fault in subsurface which are penetrated up to Moho depth. In the northeast of Bagh basement fault the northwest-southeast trending Kashmir boundary thrust has been delineated in the sedimentary-metasedimentary wedge which joins the Indus Kohistan seismic zone in the subsurface. The present study suggested that the Kawai fault which is running within Murree Formation cuts 16 km thick sedimentary-metasedimentary wedge and also joins the Indus Kohistan seismic zone in the subsurface. | Muhammad Rustam Khan Fahad Hameed Muhammad Saleem Mughal Muhammad Basharat Sohail Mustafa | 2016 | Journal of Earth Science2016，27，6： | 0 |
| 6 | Large Scale Mass Movements Triggered by the Kashmir Earthquake 2005,Pakistan显示文摘The SPOT image analysis in Muzaffarabad Azad Kashmir,northwest Himalayas,Pakistan reveals that the Kashmir earthquake 2005 triggered a number of coseismic mass movements along the hanging wall block of the Muzaffarabad Fault.The Neelidandi and Langarpura rock falls have been identified as two major reactivated mass movements with an estimated volume of 3.1 × 106m3and 5.76 × 106m3,respectively.The Neelidandi and Langarpura mass movements were initiated during earthquake in the direction of northwest-southeast extension and northeastsouthwest directed thrusting,respectively.The Neelidandi rock fall occurred in sheared cherty dolomites and limestones of the Cambrian Muzaffarabad Formation,whereas the Langarpura rock fall occurred in alternating clays,shales,claystones,siltstones and sandstones of the Miocene Murree Formation.These rock units along the fault are highly fractured and jointed.The geotechnical maps and geological longitudinal profiles show the relationship between the geometrical characteristics and mechanism of these mass movements.Their characteristics were analyzed according to the role of topographic,seismic,geological and tectonic factors.The steep topography,sheared rocks,lithology,coseismic uplift and strong ground shaking of the hanging wall block along Muzaffarabad Fault facilitated the gravity collapse of these mass movements. | Muhammad BASHARAT Joachim ROHN Mirza Shahid BAIG Muhammad Rustam KHAN Markus SCHLEIER | 2014 | Journal of Mountain Science2014，11，1： | 0 |
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