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| 1 | Non-invasive diagnosis of liver fibrosis and cirrhosis显示文摘The evaluation and follow up of liver fibrosis and cirrhosis have been traditionally performed by liver biopsy. However, during the last 20 years, it has become evident that this 'gold-standard' is imperfect; even according to its proponents, it is only 'the best' among available methods. Attempts at uncovering non-invasive diagnostic tools have yielded multiple scores, formulae, and imaging modalities. All are better tolerated, safer, more acceptable to the patient, and can be repeated essentially as often as required. Most are much less expensive than liver biopsy. Consequently, their use is growing, and in some countries the number of biopsies performed, at least for routine evaluation of hepatitis B and C, has declined sharply. However, the accuracy and diagnostic value of most, if not all, of these methods remains controversial. In this review for the practicing physician, we analyze established and novel biomarkers and physical techniques. We may be witnessing in recent years the beginning of the end of the first phase for the development of non-invasive markers. Early evidence suggests that they might be at least as good as liver biopsy. Novel experimental markers and imaging techniques could produce a dramatic change in diagnosis in the near future. | Yoav Lurie Muriel Webb Ruth Cytter-Kuint Shimon Shteingart Gerardo Z Lederkremer | 2015 | World Journal of Gastroenterology2015，21，41： | 36 |
| 2 | Pharmacogenomics in colorectal cancer: The first step for individualized-therapy显示文摘Interindividual differences in the toxicity and response to anticancer therapies are currently observed in practically all available treatment regimens. A goal of cancer therapy is to predict patient response and toxicity to drugs in order to facilitate the individualization of patient treatment. Identification of subgroups of patients that differ in their prognosis and response to treatment could help to identify the best available drug therapy according the genetic profile. Several mechanisms have been suggested to contribute to chemo-therapeutic drug resistance: amplification or overexpression of membrane transporters, changes in cellular proteins involved in detoxification or in DNA repair, apoptosis and activation of oncogenes or tumor suppressor genes. Colorectal cancer (CRC) is regarded as intrinsically resistant to chemotherapy. Several molecular markers predictive of CRC therapy have been included during the last decade but their results in different studies complicate their application in practical clinical. The simultaneous testing of multiple markers predictive of response could help to identify more accurately the true role of these polymorphisms in CRC therapy. This review analyzes the role of genetic variants in genes involved in the action mechanisms of the drugs used at present in colorectal cancer. | Eva Bandrés Ruth Zárate Natalia Ramirez Ana Abajo Nerea Bitarte Jesus García-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 3 | Moving forward in colorectal cancer research, what proteomics has to tell显示文摘Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer. | Nerea Bitarte Eva Bandrés Ruth Zárate Natalia Ramirez Jesus Garcia-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 4 | Selective removal of acetone and butanol from water with supported ionic liquid-polydimethylsiloxane membrane by pervaporation显示文摘 | Izak P Ruth W Fei Z F | 2008 | Chemical Engineering Journal (Amsterdam Netherlands)2008，139，2： | 1 |
| 5 | Sphingosine-1-phosphate protects bovine oocytes from heat shock during maturation显示文摘 | Ruth Z Hansen PJ | 2004 | Biol Rcprod2004，，6： | 1 |
| 6 | Immune hyporesponsiveness to amyloidβ-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease显示文摘 | Alon M Ruth M Victor Z | 2001 | Proc Natl AcadSci USA2001，98，10： | 1 |
| 7 | Immune hyporesponsiveness to amyloidβ-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer ' s disease显示文摘 | Alon M Ruth M Victor Z | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 8 | Mycophenolic acid: a new approach to therapy of experimental mesangial proliferative glomerulonephritis显示文摘 | Ruth Z Steinmann-niggli K Kappeler A | 1998 | J Am Soc Nephrol1998，9，： | 1 |
| 9 | Selective removal of acetone and butan-1-ol from water with supported ionic liquid-polydimethylsiloxane membrane by pervaporation显示文摘 | Izak P Ruth W Fei Z F | 2008 | Chem Eng J2008，139，2： | 1 |
| 10 | Human papillomavirus16 E6 polymorphisms in cervical lesions from different Europe-an populations and their correlation with human leukocyte anti-gen class II haplotypes 显示文摘 | Ingeborg Z Ruth T Joannis M | 2001 | International Journal of Cancer2001，94，： | 1 |
| 11 | Liver-targeted and peripheral blood Alterations of regulatory T cells in primary biliary cirrhosis 显示文摘 | RUTH Y CHENG CM LIAN Z X | 2006 | Liver Failure and Liver Disease2006，43，4： | 1 |
| 12 | multicultural peer counseling:counseling the multicul2tural student显示文摘 | Ruth H Fris Z | 1999 | Journal of Adolescence1999，22，： | 1 |
| 13 | A complex of 5 - hydroxypyn'olidin - 2 - one and pyrimidine - 2,4 - dione isolated from Jatropha curcas显示文摘 | RUTH S MANFRED S Z ALOIS H | 1999 | Phytochemistry1999，50，2： | 1 |
| 14 | Modeling Indirect Statistics of Surface Roughness 显示文摘 | Sun L Zhang Z Ruth J | 2001 | Journal of Transportation Engineering2001，127，2： | 1 |
| 15 | Immune hyporesponsiveness to amyloid β peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimers disease 显示文摘 | Alon M Ruth M Victor Z | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 16 | Modeling indirect statistics of surface roughness 显示文摘 | SUN L ZHANG Z RUTH J | 2001 | Journal of Transportation Engineering2001，127，2： | 1 |
| 17 | Association be- tween dopaminergic polymorphisms and borderline personality traits among at- risk young adults and psychiatric inpatients显示文摘 | Nemoda Z Lyons - Ruth K Szekely A | 2010 | Behaw Brain Funct2010，6，： | 1 |
| 18 | Selective removal of acetone and butan-l-ol from water with supported ionic liquid- polydimethylsiloxane membrane by pervaporation显示文摘 | Izak P Ruth W Fei Z F | 2008 | Chemical Engineering Journal2008，139，2： | 1 |
| 19 | 显示文摘 | Alon M Ruth M Victor Z | 2001 | PNAS2001，98，10： | 1 |
| 20 | The addition of silicon hydrides to olefinic double bonds显示文摘 | Speier J L Ruth Z James W | 1956 | Journal of the American Chemical Society1956，78，： | 1 |
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