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| 1 | Role of CARD15,DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases显示文摘AIM: To investigate the contribution of variants of CARD15, OCTN1/2 and DLG5 genes in disease predispo- sition and phenotypes in a large Italian cohort of pediatric patients with inflammatory bowel diseases (IBD). METHODS: Two hundred patients with Crohn’s disease (CD), 186 ulcerative colitis (UC) patients, 434 par- ents (217 trios), and 347 healthy controls (HC) were studied. Polymorphisms of the three major variants of CARD15, 1672C/T and -207G/C SNPs for OCTN genes, IGR2096a_1 and IGR2198a_1 SNPs for the IBD5 locus, and 113G/A variant of the DLG5 gene were evaluated. Potential correlations with clinical sub-phenotypes were investigated. RESULTS: Polymorphisms of CARD15 were significantly associated with CD, and at least one variant was found in 38% of patients (15% in HC, OR = 2.7, P < 0.001). Homozygosis for both OCTN1/2 variants was more com- mon in CD patients (1672TT 24%, -207CC 29%) than in HC (16% and 21%, respectively; P = 0.03), with an in- creased frequency of the TC haplotype (44.8% vs 38.3% in HC, P = 0.04). No association with the DLG5 variant was found. CD carriers of OCTN1/2 and DLG5 variants more frequently had penetrating disease (P = 0.04 and P = 0.01), while carriers of CARD15 more frequently had ileal localization (P = 0.03). No gene-gene interaction was found. In UC patients, the TC haplotype was morefrequent (45.4%, P = 0.03), but no genotype/phenotype correlation was observed. CONCLUSION: Polymorphisms of CARD15 and OCTN genes, but not DLG5 are associated with pediatric on- set of CD. Polymorphisms of CARD15, OCTN, and DLG5 genes exert a weak influence on CD phenotype. | S Cucchiara A Latiano O Palmieri AM Staiano R D'Incà G Guariso G Vieni V Rutigliano O Borrelli MR Valvano V Annese | 2007 | World Journal of Gastroenterology2007，13，8： | 9 |
| 2 | Impact of biochar application to a Mediterranean wheat crop on soil microbial activity and greenhouse gas fluxes显示文摘 | S. Castaldi M. Riondino S. Baronti F.R. Esposito R. Marzaioli F.A. Rutigliano F.P. Vaccari F. Miglietta | 2011 | Chemosphere2011，，9： | 3 |
| 3 | Soil microbial metabolism and nutrient status in a Mediterranean area as affected by plant cover显示文摘 | F.A. Rutigliano R. D’Ascoli A. Virzo De Santo | 2004 | Soil Biology and Biochemistry2004，，11： | 2 |
| 4 | Soil microbial metabolism and nutrient status in a Mediterranean area as affected by plant cover显示文摘 | RUTIGLIANO F A ASCOLI R D DE SANTO A V | 2004 | Soil Biology and Biochemistry2004，36，： | 1 |
| 5 | Spondin-2,a secreted extracellular matrix protein,is a novel diagnostic biomarker for prostate cancer显示文摘 | Lucarelli G Rutigliano M Bettocchi C Palazzo S Vavallo A Galleggiante V | 2013 | J Urol2013，190，6： | 1 |
| 6 | Soil activities related to nitrogen cycle under three plant cover types in Mediterranean environment显示文摘 | Rutigliano FA Castaldi S D'Ascoli R Papa S Carfora A Marzaioli R Fioretto A | 2009 | Applied Soil Ecology2009，43，： | 1 |
| 7 | Effect of source of supplemental selenium on uterine health and embryo quality in high-producing dairy cows显示文摘 | Cerri R L A Rutigliano H M Lima F S | 2009 | Theriogenology2009，71，7： | 1 |
| 8 | Soil microbial metabolism and nutrient status in a Mediterranean area as affected by plant cover显示文摘 | RUTIGLIANO F A ASCOLI R D DESANTO A V | 2004 | Soil Biology - Biochemis- try2004，36，： | 1 |
| 9 | Metabolic syndrome and major depression 显示文摘 | Marazziti l) Rutigliano G Baroni S | 2014 | CNS Spectr2014，19，4： | 1 |
| 10 | Assessing soil quality under intensive cultivation and tree orchards in Southern Italy显示文摘 | Bonanomi G D'Ascoli R Antignani V Capodilupo M Cozzolino L Marzaioli R Puopolo G Rutigliano F A Scelza R Scotti R | | 0，，： | 1 |
| 11 | Regulation of TGF-β1 expression by androgen deprivation therapy of prostate cancer显示文摘 | Fuzio P Ditonno P Rutigliano M | | 0，，02： | 1 |
| 12 | Soil microbialbetabolism and nutrient status in a Mediterranean area as affected by plant cover显示文摘 | Rutigliano F A A scoli R D De Santo A V | 2004 | Soil Biol Biochem2004，36，： | 1 |
| 13 | Infliximab for pediatric ulcerative colitis: a retrospective Italian multicenter study显示文摘 | S. Cucchiara E. Romeo F. Viola M. Cottone M. Fontana G. Lombardi V. Rutigliano G.L. de’Angelis T. Federici | 2008 | Digestive and Liver Disease2008，，： | 1 |
| 14 | Impact of biochar application to a Mediterranean wheat crop on soil microbial activity and greenhouse gas fluxes显示文摘 | S. Castaldi M. Riondino S. Baronti F.R. Esposito R. Marzaioli F.A. Rutigliano F.P. Vaccari F. Miglietta | 2011 | Chemosphere2011，，9： | 1 |
| 15 | Soil microbial metabolism and nutrient status in a Mediterranean area as affected by plant cover显示文摘 | Rutigliano F A Ascoli R D De Santo A V | 2004 | Soil Biology and Biochemistry2004，，36： | 1 |
| 16 | Ochratoxin A at low concentrations inhibitsin vitro growth of canine umbilical cord matrix mesenchymal stem cells through oxidative chromatin and DNA damage显示文摘 | RUTIGLIANO L VALENTINI L MARTINO N A | 2015 | Reproductive Toxicology2015，57，： | 1 |
| 17 | Soil microbial metabolism and nutrient status in a Mediterranean area as affected by plant cover 显示文摘 | Rutigliano F A D' Ascoli R De Santo A V | 2004 | Soil Biology and Biochemistry2004，36，17： | 1 |
| 18 | Electrokinetic remediation of soils contaminated with heavy metals显示文摘 | RUTIGLIANO L FINO D SARACCO G | 2008 | Journal of Applied Electrochemistry2008，38，： | 1 |
| 19 | Treatment with anti-LFA-1 delays the CD8^+ cytotoxic-T-lymphocyte response and viral clearance in mice with primary respiratory syncytial virus infection显示文摘 | Rutigliano J A Johnson T R Hollinger T N | 2004 | J Virol2004，78，6： | 1 |
| 20 | Outcomes following prolonged mechanical ventila- tion: analysis of a countywide trauma registry显示文摘 | Rubano JA Paccione MF Rutigliano DN | 2015 | J Trauma Acute Care Surg2015，78，2： | 1 |
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