|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Development and validation of ultrasound speckle tracking to quantify tendon displacement 显示文摘 | Jan W H K Ruud W S Henk J S | 2012 | Journal of Biomechanics2012，43，7： | 1 |
| 3 | Integrated design of the motion cueing system for a wright flyer simulator显示文摘 | Ruud J A W Hosman | 2005 | Journal of guidance control and dynamics2005，28，1： | 1 |
| 4 | Flow behaviour and physical chemistry of bouncing putties and related polymers in view of tectonic laboratory applications显示文摘 | Ruud W | 1985 | Tectonophysics1985，124，： | 1 |
| 5 | Chronic patients inpsychiatric institutions, psychopathology, level of functioning and need for care显示文摘 | Martinsen E W Friis S | 1998 | Acta Psychiatric Scand1998，976，1： | 1 |
| 6 | Four empirical tests of Unconscious Thought Theory显示文摘 | HILDE M H RUUD W DON V R | 2012 | Organizational Behavior and Human Decision Processes2012，，117： | 1 |
| 7 | Approximating the Finite-Time Ruin Probability Under Interest Force显示文摘 | RUUD BREKELMANS ANJA DE W AEGENAERE | 2001 | Mathematics and Economics2001，29，： | 1 |
| 8 | Grip strength parame ters and functional: Activities in young adults with unilater- al cerebral palsy compared with healthy subjects显示文摘 | van Meeteren J Rogier M Ruud W | 2007 | J Rehabil Med2007，，39： | 1 |
| 9 | Phototherapy for neonatal janndice- therapeutic effects on more than one level 显示文摘 | Ruud Hansen T W | 2010 | Seminars in Perinatology2010，34，3： | 1 |
| 10 | Work per stroke and stroke frequen- cy regulation in Olympic speed skating显示文摘 | Ruud W de oer Kim L Nilsen | 1989 | International Journal of Sport Biomechanics1989，，13： | 1 |
| 11 | Evaluation of Abbott TDx monoclonal assay of cyclosporine in whole blood显示文摘 | Thomas PM Julie W Ruud K | 1991 | Clin Chem1991，37，6： | 1 |
| 12 | Chronic patients in psychiatric institutions:Psychopathology,level of functioning and need for care显示文摘 | Ruud T Martinsen E W Fins S | | 0，，01： | 1 |
| 13 | Experimental investigation of the machining induced residual stress tensor under mechani~ cal loading 显示文摘 | Fu W Cohen P H Ruud C O | 2009 | Journal of Manufacturing Processes2009，11，2： | 1 |
| 14 | biohybrid polymer capsules 显示文摘 | Stijn F M van Dongen Hans Peter M de Hoog Ruud J R W Peters | 2009 | Chem Rev2009，，109： | 1 |
| 15 | Formation of polychlorinated benzenes during the catalytic combustion of chlorobenzene using a Pt/-A1203 catalyst 显示文摘 | Ruud W van den Brink Robert Louw | 1998 | Applied Catalysis B: Environmental1998，16，： | 1 |
| 16 | How to define and study farmers’ management capacity: theory and use in agricultural economics显示文摘 | Carin W Rougoor Ger Trip Ruud B.M Huirne Jan A Renkema | 1998 | Agricultural Economics1998，，3： | 1 |
| 17 | The role of the support and dispersion in the catalytic combustion of chlorobenzene on noble metal based catalysts 显示文摘 | Ruud W van den Brink M Krzan M M R | 2000 | Applied Catalysis B: Environmental2000，24，： | 1 |
| 18 | TEMPO oxidation ofgelatinized potato starch results in acid resistant blocks of glucuronic acid moieties显示文摘 | RUUD TE1K HAAR JOHAN W TIMMERMANS TED M SLAGHEK | 2010 | Carbohydr Polym2010，，81： | 1 |
| 19 | Focal instent restenosis near step-up roles of low and oscillating shear stress 显示文摘 | ATTILA T JOLANDA J W RUUD V H | 2002 | Circulation2002，105，23： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员