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| 1 | Innovative color jet 3D printing of levetiracetam personalized paediatric preparations显示文摘3D printing is a promising technology used in the fabrication of complex oral dosage delivery pharmaceuticals.This study first reports an innovative color jet 3D printing(CJ-3DP)technology to produce colorful cartoon levetiracetam pediatric preparations with high accuracy and reproducibility.For this study,the ideal printing ink consisted of 40%(v/v)isopropanol aqueous solution containing 0.05%(w/w)polyvinylpyrrolidone and 4%(w/w)glycerin,which was satisfied with scale-up of the production.The external and internal spatial structures of the tablets were designed to control the appearance and release,and cartoon tablets with admirable appearances and immediate release characteristics were printed.The dosage model showed a good linear relationship between the model volume and the tablet strength(r>0.999),which proved the potential of personalized administration.The surface roughness indicated that the appearance of the CJ-3DP tablets was significantly better than the first listed 3D printed drug(Spritam R).Moreover,the scanning electron microscopy and porosity results further showed that the tablets have a structure of loose interior and tight exterior,which could ensure good mechanical properties and rapid dispersion characteristics simultaneously.In conclusion,the innovative CJ-3DP technology can be used to fabricate personalized pediatric preparations for improved compliance.Due to the stable formulation and fabrication process,this technology has the potential in scale-up production. | Zengming Wang Xiaolu Han Ruxin Chen Jingru Li Jing Gao Hui Zhang Nan Liu Xiang Gao Aiping Zheng | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，3： | 2 |
| 2 | Gene expression of granulosa and cumulus cells: The prospect inpredicting the quality and developmental competence of oocytesin vitro maturation显示文摘In vitro maturation(IVM),a promising assisted reproductive technology(ART),has been evolving in clinical trials and applications.There is a huge potential demand for IVM in clinical practice because it reduces the stimulation of gonadotropins to patients and provides evidence for the safety of neonatal birth.Unfortunately,the maturation rate of oocytes in vitro is not as high as it is in vivo due to a different microenvironment.Moreover,there are still controversies in predicting the developmental capability of oocytes in IVM.The granulosa cells(GCs)and cumulus cells(CCs),closely surrounding the oocytes,play a critical role in oocytes development,while some studies have shown that they can reflect the quality of oocytes.Many studies have been conducted in terms of oocyte quality in transcriptional level in GCs and CCs of mice,Xenopus africanus,and Homo sapiens,which provides important enlightenment for the successful clinical application of IVM.However,no comprehensive reviews about how gene expression profiles affect oocytes quality have been reported.This review aimed to elucidate the gene expression profiles of GCs and CCs that have effects on the quality and developmental competence of oocytes maturation in vitro.And we also put forward a possible idea for ART in the future,integrating all gene expression profiles of GCs and CCs and predicting the quality of the oocytes. | BICHUN ZHAO XUEQING WU YITONG YUAN YUANTAO GAO XIAO LI RUOCHEN DU SUMING XU RUXIN ZHANG CHUNFANG WANG | 2020 | BIOCELL2020，44，4： | 0 |
| 3 | Vibration and sound transmission loss characteristics of porous foam functionally graded sandwich panels in thermal environment显示文摘This study investigates the vibration and acoustic properties of porous foam functionally graded(FG)plates under the influence of the temperature field.The dynamics equations of the system are established based on Hamilton's principle by using the higher-order shear deformation theory under the linear displacement-strain assumption.The displacement shape function is assumed according to the four-sided simply-supported(SSSS)boundary condition,and the characteristic equations of the system are derived by combining the motion control equations.The theoretical model of vibro-acoustic coupling is established by using the acoustic theory and fluid-structure coupling solution method under the simple harmonic acoustic wave.The system's natural frequency and sound transmission loss(STL)are obtained through programming calculations and compared with the literature and COMSOL simulation to verify the validity and reliability of the theoretical model.The effects of various factors,such as temperature,porosity coefficients,gradient index,core thickness,width-to-thickness ratio on the vibration,and STL characteristics of the system,are discussed.The results provide a theoretical basis for the application of porous foam FG plates in engineering to optimize vibration and sound transmission properties. | Wenhao YUAN Haitao LIAO Ruxin GAO Fenglian LI | 2023 | Applied Mathematics and Mechanics(English Edition)2023，44，6： | 0 |
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