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| 1 | Metabolite profile comparisons between ascending and descending colon tissue in healthy adults显示文摘BACKGROUND Obesity is a risk factor for colorectal cancer,yet metabolic distinctions between healthy right and left colon tissue,before cancer is diagnosed,remains largely unknown.This study compared right-ascending and left-descending colon tissue metabolomes to identify differences from the stool metabolome in normal weight,overweight,and obese adults.AIM To examine right and left colon tissue metabolites according to body mass index that may serve as mechanistic targets for interventions and biomarkers for colon cancer risk.METHODS Global,non-targeted metabolomics was applied to assess right-ascending and left-descending colon tissue collected from healthy adults undergoing screening colonoscopies to test the hypothesis that BMI differentially impacts colon tissue metabolite profiles.The colon tissue and stool metabolome of healthy adults(n=24)was analyzed for metabolite signatures and metabolic pathway networks implicated in progression of colorectal cancer.RESULTS Ascending and descending colon contained 504 host,food,and microbiotaderived metabolites from normal weight,overweight and obese adults grouped according to body mass index.Amino acids,lipids,and nucleotides were among the chemical types that further differentiated from the stool metabolite profiles.Normal weight adults had 46 significantly different metabolites between ascending and descending colon tissue locations,whereas there were 37 metabolite differences in overweight and 28 metabolite differences for obese adults(P<0.05).Obese adults had trimethylamine N-oxide,endocannabinoids and monoacylglycerols with different relative abundances identified between ascending and descending colon.Primary and secondary bile acids,vitamins,and fatty acids also showed marked relative abundance differences in colon tissue from overweight/obese adults.CONCLUSION There were metabolite profile differences between right-ascending and leftdescending colon tissue in healthy adults.Colon lipids and other metabolites in obese and overweight adults were distinguished from normal weight participants and associated with gut inflammation,nutrient absorption,and products of microbiota metabolism. | Bridget A Baxter Kristopher D Parker Michael J Nosler Sangeeta Rao Rebecca Craig Catherine Seiler Elizabeth P Ryan | 2020 | World Journal of Gastroenterology2020，26，3： | 2 |
| 2 | Percutaneous transluminal angioplasty balloons for endoscopic ultrasound-guided pancreatic duct interventions显示文摘BACKGROUND Endoscopic ultrasound(EUS)-guided main pancreatic duct(PD)access may be used when conventional endoscopic retrograde cholangiopancreatography(ERCP)techniques fail.The use of a percutaneous transluminal angioplasty balloon(PTAB),originally developed for vascular interventions,can be used to facilitate transmural(e.g.,transgastric)PD access and to dilate high-grade pancreatic strictures.AIM To describe the technique,efficacy,and safety of PTABs for EUS-guided PD interventions.METHODS Patients who underwent EUS with use of a PTAB from March 2011 to August 2021 were retrospectively identified from a tertiary care medical center supply database.PTABs included 3-4 French angioplasty catheters with 3-4 mm balloons designed to use over a 0.018-inch guidewire.The primary outcome was technical success.Secondary outcomes included incidence of adverse events(AEs)and need for early reintervention.RESULTS A total of 23 patients were identified(48%female,mean age 55.8 years).Chronic pancreatitis was the underlying etiology in 13(56.5%)patients,surgically altered anatomy(SAA)with stricture in 7(30.4%),and SAA with post-operative leak in 3(13.0%).Technical success was achieved in 20(87%)cases.Overall AE rate was 26%(n=6).All AEs were mild and included 1 pancreatic duct leak,2 cases of post-procedure pancreatitis,and 3 admissions for post-procedural pain.No patients required early re-intervention.CONCLUSION EUS-guided use of PTABs for PD access and/or stricture management is feasible with an acceptable safety profile and can be considered in patients when conventional ERCP cannulation fails. | Jad P AbiMansour Barham K Abu Dayyeh Michael J Levy Andrew C Storm John A Martin Bret T Petersen Ryan J Law Mark D Topazian Vinay Chandrasekhara | 2022 | World Journal of Gastrointestinal Endoscopy2022，14，8： | 2 |
| 3 | Analysis of strawberry volatiles using comprehensive two-dimensional gas chromatography with headspace solid-phase micreextraction 显示文摘 | Williams A Ryan D Guasca A O | 2005 | Journal of Chromatography B2005，817，： | 1 |
| 4 | Adiponectin Levels do not Change with Moderate Dietary Induced Weight Loss and Exercise in Obese Postmenopausal Women显示文摘 | Nickla S B J Berman D M | 2003 | Int J Obes Re-latMetab2003，27，： | 1 |
| 5 | ADAM-17 expmssion in breast cancer correlates with variables of tumor progression显示文摘 | MCGOWAN P M RYAN B M HILL A D | 2007 | Clin Cancer Res2007，13，8： | 1 |
| 6 | Stress and neurodevelopmental processes in the emergence of psychosis显示文摘 | Holtzman C W Trotman H D Ryan A T | 2013 | Neuroscience2013，249，26： | 1 |
| 7 | BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy显示文摘 | Cerchietti Leandro C Hatzi Katerina Caldas-Lopes Eloisi Yang Shao Ning Figueroa Maria E Morin Ryan D Hirst Martin Mendez Lourdes Shaknovich Rita Cole Philip A Bhalla Kapil Gascoyne Randy D Marra Marco Chiosis Gabriela Melnick Ari | 2010 | Journal of Clinical Investigation2010，，12： | 1 |
| 8 | Using fractional exhaled nitric oxide(Fe NO)to diagnose steroid-responsive disease and guide asthma management in routine care显示文摘 | Price D Ryan D Burden A | 2013 | Clin Transl Allergy2013，3，1： | 1 |
| 9 | Fabrication methods of porous metals for use in orthopaedic applications显示文摘 | Ryan G Pandit A Apatsidis D P | 2006 | Biomaterials2006，27，13： | 1 |
| 10 | PAST: Paleontological Statistics Software Package for Education and Data Analysis显示文摘 | ф Hammer D A T Harper P D Ryan | 2001 | Palaeontologia Electronica2001，4，1： | 1 |
| 11 | Wound- and systemin-inducible calmodulin gene expression in tomato leaves显示文摘 | Bergey D R Ryan C A | 1999 | Plant Molecular Biology1999，，40： | 1 |
| 12 | S1- opoke epi-cadmium neutron flux in activation analysis显示文摘 | HOLZBECHER J CHATT A RYAN D E | 1985 | Canadian Journal of Spectroscopy1985，30，3： | 1 |
| 13 | Antimi- crohial activity of commercial Olea europaea (olive) leaf extract显示文摘 | Sudjana A N D'Orazio C Ryan V | 2009 | International Journal of Antimicrobial Agents2009，33，5： | 1 |
| 14 | Altered expression of tyrosine hydroxylase in the locus eeruleans noradrenergic system in citalopram neonatally exposed rats and monoamine oxidase a knock out mice 显示文摘 | ZHANG J L RYAN D DARLING I A | 2011 | Anatomical Record2011，294，10： | 1 |
| 15 | Efficacy of steamer jet-injection as alternative to chlorine in fresh- cut lettuce 显示文摘 | Martin-Diana A B Rico D Barry Ryan C | 2007 | Postharvest Biology and Technology2007，45，1： | 1 |
| 16 | Detection and localization of interleukin-6 in the rat middle ear during experimental acute otitis media, using mRNA in situ hybridization and immuno histochemistry 显示文摘 | Melhus A Ryan AF Bagger-Sjoback D Hultcrantz M | 2001 | Int J Pediatr Otorhinolaryngol2001，157，2： | 1 |
| 17 | The dominant - white spotting (W) locus of the mouse encodes the c - kit proto - oncogene显示文摘 | GEISSLER E N RYAN M A HOUSMAN D E | 1988 | Cell1988，55，1： | 1 |
| 18 | Effects of long-chain polyamsouwated fitty acid supplementation on neurodevelopment in childhood: a review of human studies显示文摘 | RYAN A S ASTWOOD J D GAUTIER S et al | 2010 | Prostaglandins Leukotrienes and Essential Fatty Acids2010，，82： | 1 |
| 19 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 20 | Between air and water :the plunge dive of the Cape Gannet Morus capensis 显示文摘 | ROPERT-COUDERT Y D GREMILLET P RYAN A | 2004 | Ibis2004，46，： | 1 |
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