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| 1 | Total knee arthroplasty and fractures of the tibial plateau显示文摘Tibial plateau fractures are common injuries that occur in a bimodal age distribution. While there are various treatment options for displaced tibial plateau fractures, the standard of care is open reduction and internal fixation(ORIF). In physiologically young patients with higher demand and better bone quality, ORIF is the preferred method of treating these fractures. However, future total knee arthroplasty(TKA) is a consideration in these patients as post-traumatic osteoarthritis is a common long-term complication of tibial plateau fractures. In older, lower demand patients, ORIF is potentially less favorable for a variety of reasons, namely fixation failure and the need for delayed weight bearing. In some of these patients, TKA can be considered as primary mode of treatment. This paper will review the literature surrounding TKA as both primary treatment and as a salvage measure in patients with fractures of the tibial plateau. The outcomes, complications, techniques and surgical challenges are also discussed. | Kenneth A Softness Ryan S Murray Brian G Evans | 2017 | World Journal of Orthopedics2017，8，2： | 15 |
| 2 | Contemporary review of minimally invasive pancreaticoduodenectomy显示文摘AIM To assess the current literature describing various minimally invasive techniques for and to review short-term outcomes after minimally invasive pancreaticoduodenectomy(PD). METHODS PD remains the only potentially curative treatment for periampullary malignancies, including, most commonly, pancreatic adenocarcinoma. Minimally invasive approaches to this complex operation have begun to be increasingly reported in the literature and are purported by some to reduce the historically high morbidity of PD associated with the open technique. In this systematic review, we have searched the literature for high-quality publications describing minimally invasive techniques for PD-including laparoscopic, robotic, and laparoscopicassisted robotic approaches(hybrid approach). We have identified publications with the largest operative experiences from well-known centers of excellence for this complex procedure. We report primarily short term operative and perioperative results and some short term oncologic endpoints. RESULTS Minimal y invasive techniques include laparoscopic, robotic and hybrid approaches and each of these techniques has strong advocates. Consistently, across all minimally invasive modalities, these techniques are associated less intraoperative blood loss than traditional open PD(OPD), but in exchange for longer operating times. These techniques are relatively equivalent in terms of perioperative morbidity and short term oncologic outcomes. Importantly, pancreatic fistula rate appears to be comparable in most minimally invasive series compared to open technique. Impact of minimally invasive technique on length of stay is mixed compared to some traditional open series. A few series have suggestedthat initiation of and time to adjuvant therapy may be improved with minimally invasive techniques, however this assertion remains controversial. In terms of shortterms costs, minimally invasive PD is significantly higher than that of OPD. CONCLUSION Minimally invasive approaches to PD show great promise as a strategy to improve short-term outcomes in patients undergoing PD, but the best results remain isolated to high-volume centers of excellence. | Rui Dai Ryan S Turley Dan G Blazer | 2016 | World Journal of Gastrointestinal Surgery2016，8，12： | 5 |
| 3 | Clinical classification of symptomatic heterotopic pancreas of the stomach and duodenum:A case series and systematic literature review显示文摘BACKGROUND Heterotopic pancreas(HP)is an aberrant anatomic malformation that occurs most commonly in the upper gastrointestinal tract.While the majority of heterotopic pancreatic lesions are asymptomatic,many manifest severe clinical symptoms which require surgical or endoscopic intervention.Understanding of the clinical manifestations and symptoms of HP is limited due to the lack of large volume studies in the literature.The purpose of this study is to review symptomatic cases at a single center and compare these to a systematic review of the literature in order to characterize common clinical manifestations and treatment of this disease.AIM To classify the common clinical manifestations of heterotopic pancreas.METHODS A retrospective review was conducted of pathologic samples containing heterotopic pancreas from 2000-2018.Review was limited to HP of the upper gastrointestinal tract due to the frequency of presentation in this location.Symptomatic patients were identified from review of the medical records and clinical symptoms were tabulated.These were compared to a systematic review of the literature utilizing Pub Med and Embase searches for papers pertaining to heterotopic pancreas.Publications describing symptomatic presentation of HP were selected for review.Information including demographics,symptoms,presentation and treatment were compiled and analyzed.RESULTS Twenty-nine patient were identified with HP at a single center,with six of these identified has having clinical symptoms.Clinical manifestations included,gastrointestinal bleeding,gastric ulceration with/without perforation,pancreatitis,and gastric outlet obstruction.Systemic review of the literature yielded 232 publications detailing symptomatic cases with only 20 studies describing ten or more patients.Single and multi-patient studies were combined to form a cohort of 934 symptomatic patients.The majority of patients presented with abdominal pain(67%)combined with one of the following clinical categories:(1)Dyspepsia,(n=445,48%);(2)Pancreatitis(n=260,28%);(3)Gastrointestinal bleeding(n=80,9%);and(4)Gastric outlet obstruction(n=80,9%).The majority of cases(n=832,90%)underwent surgical or endoscopic resection with 85%reporting resolution or improvement in their symptoms.CONCLUSION Heterotopic pancreas can cause significant clinical symptoms in the upper gastrointestinal tract.Better understanding and classification of this disease may result in more accurate identification and treatment of this malformation. | Michael T Le Compte Brandon Mason Keenan J Robbins Motoyo Yano Deyali Chatterjee Ryan C Fields Steven M Strasberg William G Hawkins | 2022 | World Journal of Gastroenterology2022，28，14： | 3 |
| 4 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 5 | Systemins: A functionally defined familyof peptide signals that regulate defensive genes in Solanaceae-species显示文摘 | Ryan C A Pearee G | 2003 | Proc Nat/Acad Sci USA2003，25，14： | 1 |
| 6 | Evidence that decomposition rates of organic carbon in mineral soil do not vary with temperature显示文摘 | Ryan M G | 2000 | Nature2000，404，： | 1 |
| 7 | Maintenance respiration and stand development in a subalpine lodgepole pine forest显示文摘 | Ryan M G Waring R H | 1992 | Ecology1992，73，： | 1 |
| 8 | Conditional and Unconditional Conservatism: Concepts and Modeling显示文摘 | Beaver W H Ryan S G | 2005 | Review of Accounting Studies2005，10，23： | 1 |
| 9 | The laser drilling of multi-layer aerospace material systems显示文摘 | A Corcoran L Sexton B Seaman P Ryan G Byrne | 2002 | Journal of Materials Processing Tech2002，，1： | 1 |
| 10 | Fabrication methods of porous metals for use in orthopaedic applications显示文摘 | Ryan G Pandit A Apatsidis D P | 2006 | Biomaterials2006，27，13： | 1 |
| 11 | Intracellular ex- pression and processing of foot-and mouth disease virus precur- sors using vaccinia virus vectors influence of the L protease显示文摘 | Belsham G J Brangwyn J K Ryan M D | 1990 | J Virol1990，176，： | 1 |
| 12 | Risk factors for outbreaks of infectious intestinal disease linked to domestic catering显示文摘 | RYAN M J WALL P G GILBERT R J | 1996 | Commun Dis Rep CDR Rev1996，6，13： | 1 |
| 13 | MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia显示文摘 | Yu J Ryan D G Getsios S | 2008 | Proc Natl Acad Sci USA2008，105，19： | 1 |
| 14 | The detection of cytokeratins in lymph nodes of Duke's B colorectal cancer subjects predicts a poor outcome显示文摘 | Clarke G Ryan E O'Keane JC | 2000 | Eur J Gastroenterol Hepatol2000，12，5： | 1 |
| 15 | Unmanned aerial vehicle (UAV) route selection using reactive tabu search显示文摘 | Ryan J L T G Bailey J T Moore W B Carlton | 1999 | Military Operations Research1999，4，3： | 1 |
| 16 | Foliage,fineroot,woody-tissue and stand respiration in Pinus radiata in relation to nutrient content显示文摘 | Ryan M G Hubbard R M Pongracic S | 1996 | Tree Physiology1996，16，： | 1 |
| 17 | An improved un- derstanding of soil Cd risk to humans and low cost meth- ods to phytoextract Cd from contaminated soils to prevent soil Cd risks 显示文摘 | Chaney R L Reeves P G Ryan J A | 2004 | Biometals2004，17，： | 1 |
| 18 | The importance of self determina- tion theory for medical education 显示文摘 | Williams G Saizow R Ryan R | 1999 | Acad Med1999，74，9： | 1 |
| 19 | Primarydiffuse large B-cell lymphoma of the breast:prognostic factorsand outcomes of a study by the International ExtranodalLymphoma Study Group显示文摘 | Ryan G Martinelli G Kuper-Hommel M | 2008 | Ann Oncol2008，19，2： | 1 |
| 20 | Woody tissue main- tenance respiration of four conifers in contrasting climates 显示文摘 | Ryan M G Gower S T Hubbard R M | 1995 | Oecologia1995，101，2： | 1 |
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