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| 1 | Central line-associated bloodstream infection among children with biliary atresia listed for liver transplantation显示文摘BACKGROUND Pre-transplant nutrition is a key driver of outcomes following liver transplantation in children.Patients with biliary atresia(BA) may have difficulty achieving satisfactory weight gain with enteral nutrition alone,and parenteral nutrition(PN) may be indicated.While PN has been shown to improve anthropometric parameters of children with BA listed for liver transplantation,less is known about the risks,particularly infectious,associated with this therapy among this specific group of patients.AIM To describe the incidence,microbiology,and risk factors of central line-associated bloodstream infection(CLABSI) among children with BA listed for liver transplantation.METHODS Retrospective review of children aged ≤ 2-years of age with BA who were listed for primary liver transplantation at Texas Children's Hospital from 2008 through2015(n = 96).Patients with a central line for administration of PN(n = 63) were identified and details of each CLABSI event were abstracted.We compared the group of patients who experienced CLABSI to the group who did not,to determine whether demographic,clinical,or laboratory factors correlated with development of CLABSI.RESULTS Nineteen of 63 patients(30%,95%CI:19,43) experienced 29 episodes of CLABSI during 4800 line days(6.04 CLABSI per 1000 line days).CLABSI was predominantly associated with Gram-negative organisms(14/29 episodes,48%)including Klebsiella spp.,Enterobacter spp.,and Escherichia coli.The sole polymicrobial infection grew Enterobacter cloacae and Klebsiella pneumoniae.Grampositive organisms(all Staphylococcus spp.) and fungus(all Candida spp.)comprised 9/29(31%) and 6/29(21%) episodes,respectively.No demographic,clinical,or laboratory factors were significantly associated with an increased risk for the first CLABSI event in Cox proportional hazards regression analysis CONCLUSION There is substantial risk for CLABSI among children with BA listed for liver transplantation.No clinical,demographic,or laboratory factor we tested emerged as an independent predictor of CLABSI.While our data did not show an impact of CLABSI on the short-term clinical outcome,it would seem prudent to implement CLABSI reduction strategies in this population to the extent that each CLABSI event represents potentially preventable hospitalization,unnecessary healthcare dollar expenditures,and may exact an opportunity cost,in terms of missed allograft offers. | Nicole D Triggs Stacey Beer Sonam Mokha Kat Hosek Danielle Guffey Charles G Minard Flor M Munoz Ryan W Himes | 2019 | World Journal of Hepatology2019，11，2： | 2 |
| 2 | Fabrication methods of porous metals for use in orthopaedic applications显示文摘 | Ryan G Pandit A Apatsidis D P | 2006 | Biomaterials2006，27，13： | 1 |
| 3 | Intracellular ex- pression and processing of foot-and mouth disease virus precur- sors using vaccinia virus vectors influence of the L protease显示文摘 | Belsham G J Brangwyn J K Ryan M D | 1990 | J Virol1990，176，： | 1 |
| 4 | MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia显示文摘 | Yu J Ryan D G Getsios S | 2008 | Proc Natl Acad Sci USA2008，105，19： | 1 |
| 5 | Recent oceurrenee of Cylindrospermopsis raciborskii in Waikato lakes of New Zealand显示文摘 | Ryan E F Hamilton D P Barnes G 2003 | 2003 | New Zealand Journal of Marine and Freshwater Research2003，37，： | 1 |
| 6 | The Brazil Eucalyptus Potential Productivity Project: Influence of water, nutrients and stand uniformity on wood production显示文摘 | Stape J L Binkley D Ryan M G | 2010 | Forest Ecology and Management2010，259，9： | 1 |
| 7 | Lithium abundance and isotope systematics of forearc serpentinites, Conical Sea- mount, Mariana forearc: Insights into the mechanics of slab- mantle exchange during subduction显示文摘 | Benton L D Ryan J G Savov I P | 2004 | Geochemistry Geo- physics Geosystems2004，5，8： | 1 |
| 8 | Rapid regulation of microRNA following induction of long-term potentiation in vivo显示文摘 | Joilin G Guévremont D Ryan B | 2014 | Front Mol Neurosci2014，7，： | 1 |
| 9 | Umbilical artery blood flow velocity in pregnancies complicated by systemic lupus erythematosus显示文摘 | Farine D Granovsky GS Ryan G | 1998 | Clin Ultrasound1998，，26： | 1 |
| 10 | Woody-tissue respi- ration for Simarouba amara and Mirutuartia guianensis, two tropi- cal wet forest trees with different growth habits显示文摘 | Ryan M G Hubbard R M Clark D A | 1994 | Oecologia1994，100，3： | 1 |
| 11 | The innate immune response of the respiratory epithelium 显示文摘 | Diamond G Legarda D Ryan L K | 2000 | Immunol Rev2000，173，： | 1 |
| 12 | Hospital Quality, Efficiency, and Input Slack Differentials 显示文摘 | Vivian G Valdmanis Michael D Rosko Ryan L Mutter | 2008 | Health Serv Res2008，43，52： | 1 |
| 13 | Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits : serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial显示文摘 | Jenkins D J A Kendall C W C Vuksan V Vidgen E Parker T Faulkner D Mehling C C Garsetti M Testolin G Cunnane S C Ryan bl A Corey P N | 2002 | The American Journal of Clinical Nutrition2002，75，5： | 1 |
| 14 | A novel early-stage orthotopic model for ovarian cancer in the Fischer344 rat显示文摘 | Sloan Stakleff K D Rouse A G Ryan A P | 2005 | Int J Gynecol Cancer2005，15，2： | 1 |
| 15 | Primary production and carbon allocation in relation to nutrient supply in a tropical experimental forest 显示文摘 | GIARDINA C P RYAN M G BINKLEY D | 2003 | Global Change Biology2003，9，： | 1 |
| 16 | Synthesis of foot-and-mouth disease virus pentamer-like structures in insect cells using haculovirus expression vectors 显示文摘 | ROOSIEN J BELSHAM G J RYAN M D | 1990 | J Gen Virol1990，71，： | 1 |
| 17 | Recent occurrence of Cylindrospermopsis raciborskii in Waikato lakes of New Zealand 显示文摘 | Ryan E F Hamilton D P Barnes G | 2003 | New Zealand Journal of Marine and Freshwater Research2003，37，： | 1 |
| 18 | J Heterocyck Chem显示文摘 | Salisbury R G Ryan D P Mason J W | 1967 | (4) :4311967，，4： | 1 |
| 19 | Comparing nocturnal eddy covariance measurement to estimate of ecosystem respiration made by scaling chamber measurements at six coniferous boreal sites显示文摘 | Lavigne M B Ryan M G Andersson D E | 1997 | Journal of Geophysical Research1997，102，28： | 1 |
| 20 | A general biochemistry model describing the responses of the C and N cycles in terresrial ecosystems to changes in CO2, climate and N deposition显示文摘 | B E Ryan M G Shaver G R Melillo J M Nadelhoffer K J Hobbie J E Aber J D | 1991 | Tree Physiology1991，9，： | 1 |
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