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| 1 | Ever-increasing diversity of drug-induced pancreatitis显示文摘With over 100000 hospital admissions per annum,acute pancreatitis remains the leading gastrointestinal cause of hospitalization in the United States and has farreaching impact well beyond.It has become increasingly recognized that druginduced pancreatitis(DIP),despite accounting for less than 3%of all cases,represents an important and growing though often inconspicuous cause of acute pancreatitis.Nevertheless,knowledge of DIP is often curtailed by the limited availability of evidence needed to implicate given agents,especially for nonprescription medications.Indeed,the majority of available data is derived from case reports,case series,or case control studies.Furthermore,the mechanism of injury and causality for many of these drugs remain elusive as a definitive correlation is generally not established(<10%of cases).Several classification systems have been proposed,but no single system has been widely adopted,and periodic updates are required in light of ongoing pharmacologic expansion.Moreover,infrequently prescribed medications or those available over-thecounter(including herbal and other alternative remedies)are often overlooked as a potential culprit of acute pancreatitis.Herein,we review the ever-increasing diversity of DIP and the potential mechanisms of injury with the goal of raising awareness regarding the nature and magnitude of this entity.We believe this manuscript will aid in increasing both primary and secondary prevention of DIP,thus ultimately facilitating more expedient diagnosis and a decrease in DIPrelated morbidity. | Simcha Weissman Muhammad Aziz Ryan B Perumpail Tej I Mehta Rutwik Patel James H Tabibian | 2020 | World Journal of Gastroenterology2020，26，22： | 8 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | HIF-1α is required for solid tumor formation and embryonic vascularization显示文摘 | Ryan H E Lo J Johnson R S | 1998 | EMBO J1998，17，11： | 2 |
| 4 | Hypoxia in cartilage: HIF-1αis essential for chondrocyte growth arrest and survival显示文摘 | Schipani E Ryan H E Didrickson S | 2001 | Genes Develop2001，15，21： | 2 |
| 5 | Hypoxia-inducible factor-1 alpha is essential for cell cycle arrest during hypoxia 显示文摘 | Goda N Ryan H E Khadivi B | 2003 | Mol Cell Biol2003，23，1： | 1 |
| 6 | Identification and estimation of discrete games of complete information 显示文摘 | P Bajari H Hong and S Ryan | 2008 | NBER Working paper2008，，： | 1 |
| 7 | Low-gain integral control of continuous-time linear systems subject to input and output nonlinearities显示文摘 | FLIEGNER T LOGEMANN H RYAN E P | 2003 | Automatica2003，39，： | 1 |
| 8 | Maintenance respiration and stand development in a subalpine lodgepole pine forest显示文摘 | Ryan M G Waring R H | 1992 | Ecology1992，73，： | 1 |
| 9 | Experimental epiretinal proliferation induced by intravitreal red blood cells显示文摘 | Miller B Miller H Ryan SJ | 1986 | Am J Ophthalmol1986，102，2： | 1 |
| 10 | Constitutive analysis in hot wor- king显示文摘 | Mcqueen H J Ryan N D | 2002 | Mater Sci Eng A2002，322，12： | 1 |
| 11 | Dissimilar immunogenicities ofhuman papillomavirus E7 and adenovirus E1A proteins influenceprimary tumor development显示文摘 | Routes JM Ryan S Li H | 2000 | Virology2000，277，1： | 1 |
| 12 | Conditional and Unconditional Conservatism: Concepts and Modeling显示文摘 | Beaver W H Ryan S G | 2005 | Review of Accounting Studies2005，10，23： | 1 |
| 13 | Stress and neurodevelopmental processes in the emergence of psychosis显示文摘 | Holtzman C W Trotman H D Ryan A T | 2013 | Neuroscience2013，249，26： | 1 |
| 14 | Surface crosslinking of polyethylene and adhesive joint strength显示文摘 | SCHONHORN H RYAN F W | 1974 | Appl Polym Sci1974，18，1： | 1 |
| 15 | Transport of ironbased nanoparticles: role of magnetic properties 显示文摘 | Yongsuk Ho Ryan J H Nosang V | 2009 | Environmental Science & Technology2009，43，23： | 1 |
| 16 | Involvement of toll-like receptor(TLR)2 and TLR4 in cell activation by mannuronic acid polymers 显示文摘 | Flo T H Ryan L Latz E | 2002 | J Biol Chem2002，277，35： | 1 |
| 17 | Effect of Surface Roughness on Paper Substrate Circuit Board显示文摘 | Ryan A and Lewis H | 2012 | IEEE Transactions on Components Packaging and Manufacturing Technology2012，2，7： | 1 |
| 18 | The interactions between R&D investment decisions and compensation policy显示文摘 | RYAN H E WIGGINS R A | 2002 | Financial management2002，31，1： | 1 |
| 19 | Using electrically conductive inks and adhesives as a means to satisfy european PCB manufacturing directives 显示文摘 | Lewis H J Ryan A | 2008 | J Adhesion Sci Techn2008，，22： | 1 |
| 20 | Placenta accreta postpartum 显示文摘 | Ryan G L Quinn T J Syrop C H | 2002 | Obstet Gynecol2002，100，11： | 1 |
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