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| 1 | Cytokines,cytokine gene polymorphisms and Helicobacter pylori infection:Friend or foe?显示文摘Helicobacter pylori(H.pylori)is a flagellated,spiralshaped,microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50%of the human population.Infection is a risk factor for gastritis,ulcer disease and stomach cancer.Immunity against H.pylori is mainly related to Th1/Th17 skewing,and the activation of regulatory T cells is the main strategy used to limit inflammatory responses,which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases,including cancer.Furthermore,host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases.In this review,we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H.pylori and discuss how such polymorphisms may influence infection/disease outcomes. | Camila A Figueiredo Cintia Rodrigues Marques Ryan dos Santos Costa Hugo Bernardino F da Silva Neuza M Alcantara-Neves | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 2 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 3 | The nature and distribution of Messinian erosional surface-Indicators of a several-kilometerdeep Mediterranean in Miocene显示文摘 | Ryan W B F Cita M B | 1978 | Marine Geology1978，27，34： | 1 |
| 4 | PAPNET-direeted resereening of cervicovaginal smears:a study of 101 cases of atypical squamous cells of undetermined significauce显示文摘 | Ryan M R Stastny J F Remmers R | 1996 | Am J Clin Pathol1996，105，6： | 1 |
| 5 | Electron beam lithography-resolution limits显示文摘 | Broers A N Hoole A C F Ryan J M | 1996 | Microelectronic Engineering1996，32，： | 1 |
| 6 | Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells 显示文摘 | Ryan C J Zavodovskaya M Youngren J F | 2008 | Prostate2008，68，11： | 1 |
| 7 | An information-theoretic primer on complexity, self-organization, and emergence 显示文摘 | Prokopenko M Boschetti F Ryan A | 2009 | Complexity2009，15，1： | 1 |
| 8 | Design,operation,and motion characteristics of a precise piezoelectric linear motor 显示文摘 | KING F H RYAN V PINAR M | 2010 | Precision Engineering2010，34，2： | 1 |
| 9 | Perturbation method in gas-assisted power-law fluid displacement in a circular tube and a rectangular channel显示文摘 | Kamilsli F Ryan M E | 1999 | Chemical Engineering Journal1999，75，： | 1 |
| 10 | Ultrastructure of antennal sensilla of Nebria brevicollis (Fabricius) ( Coleoptera: Carabidae) 显示文摘 | DALY P J RYAN M F | 1979 | Int J Morphol & Embryol1979，8，： | 1 |
| 11 | Impact of dentofacialdeformity and motivation for treatment:a qualitative study 显示文摘 | Ryan F S Barnard M Cunningham S J | 2012 | Am JOrthod Dentofacial Orthop2012，141，6： | 1 |
| 12 | Cyclic di-GMP signaling in bacteria: recent advances and new puzzles显示文摘 | RYAN R P FOUHY Y LUCEY J F AND DOW J M | 2007 | Nat Rev Mierobiol2007，188，24： | 1 |
| 13 | GDNF protects the cochlea against noise damage显示文摘 | Keithley E M Ma C L Ryan A F | 1998 | Neuroreport1998，13，： | 1 |
| 14 | Quasi-one-dimensional high-speed engine model with finite-rate chemistry 显示文摘 | OBRIEN Timothy F STARKEY Ryan P LEWIS M J | 2001 | Journal of Propulsion and Power2001，17，6： | 1 |
| 15 | Cultural Diversity in the Workforce显示文摘 | M Fine F Johnson M S Ryan | 1990 | Public Personnel Management1990，，： | 1 |
| 16 | Phenanthrene degrader community dynamicin rhizosphere soil from a common annual grass显示文摘 | Ryan K M Mary K F | 2000 | Environ Qual2000，29，： | 1 |
| 17 | What are orthognathicpatients' expectations of treatment outcome-a qualitative study 显示文摘 | Ryan F S Barnard M Cunningham S J | 2012 | JOral Maxillofac Surg2012，70，11： | 1 |
| 18 | Investigation for photo-aging of ZnS type phosphor 显示文摘 | Ryan F M | 1981 | Luminaire1981，2425，： | 1 |
| 19 | Identification and purification of natural killer cell stimulatory factor(NKSF),a cytokine with multiple biologic effects on human lymphocytes显示文摘 | Kobayashi M Lori F Ryan M | 1989 | J Exp Med1989，170，： | 1 |
| 20 | Use of 16S-rRNA Based Techniques to Investigate the EcologocalSuccession of Microbial Populations in the Immature Lamb Rumen:Tracking of a Specific strain of Inoculated Ruminococcus and Interactions with Other Microbial Populations in vivo显示文摘 | Smith W J M Ryan F M E | 1999 | Microbial Ecol1999，38，： | 1 |
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