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| 1 | Mean platelet volume in diabetics显示文摘 | Saigo K Yasunaga M Ryo R | 1992 | Rinsho Byori1992，40，2： | 1 |
| 2 | Low-intensity pulsed ultra sound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study显示文摘 | Takeuchi R Ryo A Komitsu N | 2008 | Arthritis Res Ther2008，10，4： | 1 |
| 3 | Treatment of post-transfusion graft-versus-host disease with nafmostat mesilate,a serine protease inhibitor显示文摘 | Ryo R Saigo K Hashimoto M | 1999 | Vox Sang1999，76，4： | 1 |
| 4 | Mean platelet Volume in diabetics显示文摘 | Yasunaga M Ryo R | 1992 | Rinsho Byori1992，40，2： | 1 |
| 5 | Therapeutic strategy for post-transfusion graft-vs-host disease显示文摘 | Saigo K Ryo R | 1999 | Int J Hematol1999，69，3： | 1 |
| 6 | Loss of Pinl function in the mouse resembles the cyclin Dl-null phenotypes 显示文摘 | Liou YC Ryo R Huang HK | 2002 | Proc Natl Acad Sci USA2002，99，3： | 1 |
| 7 | Organic/in- organic nanocomposite star polymers via atom transfer radical polymerization of methyl methaerylate using oetafunctional sils- esquioxane cores显示文摘 | Costa R O R Vasconcelos W L Tamaki Ryo | 2001 | Macromolecules2001，34，： | 1 |
| 8 | Transcatheter closure of secundum atrial septal defect显示文摘 | Shimpo H Hojo R Ryo M | 2013 | Gen Thorac Cardiovasc Surg2013，61，11： | 1 |
| 9 | Low-intensity pulsed ultra- sound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures: a basic science study 显示文摘 | Takeuchi R Ryo A Komitsu N | 2008 | Arthritis Res Ther2008，10，4： | 1 |
| 10 | Loop-mediated isothermal amplification (LAMP) assays for detection of Theileria parva infections targeting the PIM and plS0 genes显示文摘 | Oriel M M T Natasha E R Ryo N | 2010 | International Journal for Parasitology2010，40，： | 1 |
| 11 | Loss of Pin1 function in the mouse resembles the cyclinD1- null phenotypes 显示文摘 | Liou Y C Ryo R Huang H K | 2002 | Proc Natl Acad Sci USA2002，99，3： | 1 |
| 12 | Loss of Pin 1 function in the mouse resembles the cyclin D1-null phenotypes显示文摘 | Liou YC Ryo R Huang HK | 2002 | Proc Natl Acad Sci USA2002，99，3： | 1 |
| 13 | Loss of Pinl function in the mouse resembles the cyclin D1-null phenotypes显示文摘 | Liou Y C Ryo R Huang H K | 2002 | Proc Natl Acad Sci USA2002，99，3： | 1 |
| 14 | Loss of Pin1 function in the mouse resembles the cyclin D1-null phenotypes显示文摘 | Liou YC Ryo R Huang HK | 2002 | Proc Natl Acad Sci U S A2002，99，3： | 1 |
| 15 | Lowintensity pulsed ultrasound activates the phosphatidylinositol 3 kinase/Akt pathway and stimulates the growth of chondrocytes in three-dimensional cultures:a basic science study显示文摘 | Takeuchi R Ryo A Komitsu N | 2008 | Arthritis Res Ther2008，10，4： | 1 |
| 16 | Transcatheter closure of secundum atrial septal defect显示文摘 | Shimpo H Hojo R Ryo M | 2013 | Gen Thorac Cardiovasc Surg2013，61，11： | 1 |
| 17 | Specific Roles of the p110α Isoform of Phosphatidylinsositol 3-Kinase in Hepatic Insulin Signaling and Metabolic Regulation显示文摘 | Victoria R S Pixu L Ryo S | 2010 | Cell Metab2010，11，3： | 1 |
| 18 | Loss of Pin1 function in the mouse resembles the cyclin D1-null phenotypes 显示文摘 | Liou YC Ryo R Huang HK | 2002 | Proc Natl Acad Sci USA2002，99，： | 1 |
| 19 | Transcatheter closure of secundum atrial septal defect显示文摘 | SHIMPO H HOJO R RYO M | 2013 | Gen Tho- rac Cardiovasc Surg2013，61，： | 1 |
| 20 | Human IgG1 antibodies suppress angiogenesis in a target-independent manner显示文摘Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s population.The most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human VEGFA.Although bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in mice.Here we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage migration.Other approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized mice.This anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated signaling.Furthermore,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA mice.Finally,mice deficient in FcγRI exhibited increased developmental and pathological angiogenesis.These findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies. | Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 0 |
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