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| 1 | Pros- tate cancer genomics, biology, and risk assessment through ge- nome- wide association studies 显示文摘 | Hidewaki Nakagawa Shusuke Akamatsu Ryo Takata | 2012 | Cancer Science2012，103，： | 1 |
| 2 | Development of risky varices in alcoholic cirrhosis with a well-maintained nutritional status显示文摘AIM: To compare the nutritional status between alcoholic compensated cirrhotic patients and hepatitis C virus(HCV)-related cirrhotic patients with portal hypertension.METHODS: A total of 21 patients with compensated cirrhosis(14 with HCV-related cirrhosis and seven with alcoholic cirrhosis) who had risky esophageal varices were investigated. In addition to physical variables, including the body mass index, triceps skinfold thickness, and arm-muscle circumference, the nutritional status was also assessed using the levels of pre-albumin(pre-ALB), retinol-binding protein(RBP) and non-protein respiratory quotient(NPRQ) measured with an indirect calorimeter.RESULTS: A general assessment for the nutritional status with physical examinations did not show a significant difference between HCV-related cirrhosis and alcoholic cirrhosis. However, the levels of pre-ALB and RBP in alcoholic compensated cirrhotic patients were significantly higher than those in HCV-related compensated cirrhotic patients. In addition, the frequency of having a normal nutritional status(NPRQ ≥ 0.85 and ALB value > 3.5 g/d L) in alcoholic compensated cirrhotic patients was significantly higher than that in HCV-related compensated cirrhotic patients.CONCLUSION: According to our small scale study, alcoholic compensated cirrhotic patients can develop severe portal hypertension even with a relatively well-maintained liver function and nutritional status compared with HCV-related cirrhosis. | Hirayuki Enomoto Yoshiyuki Sakai Yoshinori Iwata Ryo Takata Nobuhiro Aizawa Naoto Ikeda Kunihiro Hasegawa Chikage Nakano Takashi Nishimura Kazunori Yoh Akio Ishii Tomoyuki Takashima Hiroki Nishikawa Hiroko Iijima Shuhei Nishiguchi | 2015 | World Journal of Hepatology2015，7，21： | 0 |
| 3 | Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure显示文摘The surface topography of a material can influence osteoclast activity.However,the surface structural factors that promote osteoclast activity have not yet been investigated in detail.Therefore,we investigated osteoclastogenesis by testing various defined patterns with different dimensions and shapes.The systematic patterns,made of a cyclo-olefin polymer,were prepared at a micron-,submicron-,and nano-scale with a groove,hole,or pillar shape with a 1:1 pitch ratio.RAW264.7 cells were cultured on these patterns in the presence of the receptor activator of NF-κB ligand(RANKL).Osteoclast formation was induced in the order:pillar>groove≥hole.The two-dimensional factors also indicated that submicron-sized patterns strongly induced osteoclast formation.The optimal pillar dimension for osteoclast formation was 500 nm in diameter and 2μm in height.Furthermore,we observed two types of characteristic actin structure,i.e.,belt-like structures with small hollow circles and isolated ring-like structures,which formed on or around the pillars depending on size and height.Furthermore,resorption pits were observed mainly on the top of calcium phosphate-coated pillars.Thus,osteoclasts prefer convex shapes,such as pillars for differentiation and resorption.Our results indicate that osteoclastogenesis can be controlled by designing surfaces with specific morphologies. | Tsukasa Akasaka Miho Tamai Yoshitaka Yoshimura Natsumi Ushijima Shinichiro Numamoto Atsuro Yokoyama Hirofumi Miyaji Ryo Takata Shuichi Yamagata Yoshiaki Sato Ko Nakanishi Yasuhiro Yoshida | 2022 | Nano Research2022，15，5： | 0 |
| 4 | Erratum to: Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure显示文摘The article“Different micro/nano-scale patterns of surface materials influence osteoclastogenesis and actin structure”,written by Tsukasa Akasaka,Miho Tamai,Yoshitaka Yoshimura,Natsumi Ushijima,Shinichiro Numamoto,Atsuro Yokoyama,Hirofumi Miyaji,Ryo Takata,Shuichi Yamagata,Yoshiaki Sato,Ko Nakanishi,and Yasuhiro Yoshida,was originally published electronically on the publisher’s internet portal on January 17,2022 without open access. | Tsukasa Akasaka Miho Tamai Yoshitaka Yoshimura Natsumi Ushijima Shinichiro Numamoto Atsuro Yokoyama Hirofumi Miyaji Ryo Takata Shuichi Yamagata Yoshiaki Sato Ko Nakanishi Yasuhiro Yoshida | 2022 | Nano Research2022，15，5： | 0 |
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