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| 1 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 2 | Favorable clinical outcomes of three-dimensional computer-optimized high-dose-rate prostate brachytherapy in the management of localized prostate cancer显示文摘 | Yamada Y Bhatia S Zaider M | 2006 | Brachytherapy2006，5，： | 1 |
| 3 | Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture:suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency显示文摘 | Popovici RM Lu M Bhatia S | 2001 | J Clin Endocrinol Metab2001，86，6： | 1 |
| 4 | Pleuropulmonary blastoma:a clinicopathologic study of 50 cases显示文摘 | Priest JR McDermott MB Bhatia S | 1997 | Cancer1997，80，1： | 1 |
| 5 | Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome显示文摘 | Bhatia M Moochhala S | 2004 | J Pathol2004，202，2： | 1 |
| 6 | Efficacy of less invasive posterior lumbar interbody fusion as revision surgery forpatients with recurrent symptoms after discectomy 显示文摘 | Lakkol S Bhatia C Taranu R | 2011 | J Bone Joint Surg(Br)2011，93，11： | 1 |
| 7 | Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis显示文摘 | Zhang H Moochhala S M Bhatia M | 2008 | J Immunol2008，181，6： | 1 |
| 8 | Prophylactic dexam-ethasone for postoperative nausea and vomiting in pediatric strabis-mus surgery : a dose ranging and safety evaluation study 显示文摘 | Madan R Bhatia A Chakithandy S | 2005 | Anesth Analg2005，100，： | 1 |
| 9 | Modification of coal tar pitch by chemical method to reduce benzo(a)pyrene显示文摘 | Kaushi S Raina R K Bhatia G | 2007 | Current Science2007，93，： | 1 |
| 10 | Comparison of posterior and subcostal approaches to ultrasound-guided transverse abdominis plane block for postoperative analgesia in laparoscopic cholecystectomy显示文摘 | Bhatia N Arora S Jyotsna W | 2014 | J Clin Anesth2014，26，4： | 1 |
| 11 | Com- patibility of biodegradable poly ( lactic acid ) ( PLA ) and poly( butylene succinate) (PBS) blends for packaging ap- plication 显示文摘 | BHATIA A GUPTA R BHATrACHARYA S | 2007 | Korean-Aust Rheology J2007，19，3： | 1 |
| 12 | A generalised dynamic model for char particle gasification with structure evolution and peripheral fragmentation显示文摘 | WANG F Y BHATIA S K | 2001 | Chem Eng Sci2001，56，12： | 1 |
| 13 | Development and validation of a new technique for ultrasound-guided stellate ganglion block显示文摘 | Gofeld M Bhatia A Abbas S | 2009 | Reg Anesth Pain Med2009，34，5： | 1 |
| 14 | Sleep disorder in Parkinson's disease显示文摘 | Kumar S Bhatia M Behari M | 2002 | Mov Disord2002，17，： | 1 |
| 15 | A case report on XO/XX/XXX mixoploidy in goat 显示文摘 | Bhatia S Shanker V | 1990 | The Veterinary Record1990，126，： | 1 |
| 16 | Variation of the pore structure of coal chars during gasification显示文摘 | Feng Bo Bhatia S K | 2003 | Carbon2003，41，1： | 1 |
| 17 | Variation of the pore structure of coal chars during gasification显示文摘 | FENG B BHATIA S K | 2003 | Carbon2003，41，3： | 1 |
| 18 | Role of inflamma--tory mediators in thepatho- physiology of a--cute respiratory distress syndrome显示文摘 | Bhatia M Moochhala S | 2004 | JPathol2004，202，2： | 1 |
| 19 | Inflammatory mediators in acut epancreatitis 显示文摘 | Bhatia M Brady M Shokuhi S | 2009 | J Pathol2009，190，2： | 1 |
| 20 | Oxygen separation from air using ceramic-based membrane technology for sustainable fuel production and power generation 显示文摘 | Hashim S S Mohamed A R Bhatia S | 2011 | Renewable and Sustainable Energy Reviews2011，15，2： | 1 |
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