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| 1 | Predictors of disease severity in ulcerative colitis patients from Southwestern Ontario显示文摘AIM:To understand the demographic characteristics of patients in Southwestern Ontario,Canada with ulcerative colitis(UC)in order to predict disease severity. METHODS:Records from 1996 to 2001 were exam- ined to create a database of UC patients seen in the London Health Sciences Centre South Street Hospital Inflammatory Bowel Disease Clinic.To be included, patients'charts were required to have information of their disease presentation and a minimum of 5 years of follow-up.Charts were reviewed using standardized data collection forms.Disease severity was generated during the chart review process,and non-endoscopic Mayo Score criteria were collected into a composite. RESULTS:One hundred and two consecutive patients'data were entered into the database.Demographic analyses revealed that 51%of the patients were male, the mean age at diagnosis was 39 years,13.7%had a first degree relative with inflammatory bowel disease (IBD),61.8%were nonsmokers and 24.5%were ex-smokers.In 22.5%of patients the disease was limited to the rectum,in 21.6%disease was limited to the sigmoid colon,in 22.5%disease was limited to the left colon,and 32.4%of patients had pancolitis. Standard multiple regression analysis which regressed a composite of physician global assessment of disease severity,average number of bowel movements,and average amount of blood in bowel movements on year of diagnosis and age at time of diagnosis was significant,R 2=0.306,F(7,74)=4.66,P<0.01. Delay from symptoms to diagnosis of UC,gender, family history of IBD,smoking status and disease severity at the time of diagnosis didnot significantly predict the composite measure. CONCLUSION:UC severity is associated with younger age at diagnosis and year of diagnosis in a longitudinal cohort of UC patients,and may identify prognostic UC indicators. | Lee S Roth Nilesh Chande Terry Ponich Maya L Roth James Gregor | 2010 | World Journal of Gastroenterology2010，16，2： | 4 |
| 2 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 3 | Fungal inoculum properties and its effect on growth and enzyme activity of trametes versicolor in soil 显示文摘 | Schmidt K R Chand S Gostomski P A | 2005 | Biotechnol Prog2005，21，： | 1 |
| 4 | Fungal inoculum properties and its effect on growth and enzyme activity of Trametes versicolor in soil显示文摘 | Schmidt K R Chand S Gostomski P A | 2005 | Biotechnol Prog2005，21，2： | 1 |
| 5 | The single-item lot-sizing problem with immediate lost sales显示文摘 | Aksen D Altmkemer K Chand S | 2003 | European Journal of Operational Research2003，147，： | 1 |
| 6 | Phoma glomerata,a new pathogen on pears(Pyrus communis)显示文摘 | Chohan J S Chand T | | 0，，3： | 1 |
| 7 | Recovery ofpropionic acid from aqueous phase by reactive extraction using quartemary amine (aliquat 336) in various diluentS显示文摘 | KESHAVA CHAND S WASEWAR K L | 2009 | Chemical Engineering Journal2009，152，1： | 1 |
| 8 | Review carbon fibers for composites 显示文摘 | Chand S | 2000 | Journal of Material Science2000，35，： | 1 |
| 9 | A dynamic lot sizing model with learning in setups 显示文摘 | Chand S Sethi S P | 1990 | Operations Research1990，38，4： | 1 |
| 10 | Mutational analysis of BMP15 and GDF9 as candidate genes for premature ovarian failure显示文摘 | Chand A L Ponnampalam A P Harris S E | 2006 | Fertil Steril2006，86，4： | 1 |
| 11 | Catalytic wet per- oxide oxidation of azo dye(Congo Red) using modified Y zeolite as catalyst显示文摘 | Kondru A K Kumar P Chand S | 2009 | Hazard Mater2009，166，1： | 1 |
| 12 | Extraction of acrylic, propionic, and butyric acid using aliquat 336 in oleyl alcohol: equilibria and effect of tempemtttre显示文摘 | KESHAVA WASEWAR K L CHAND S | 2009 | Industrial & Engineering Chemistry Research2009，48，2： | 1 |
| 13 | Review carbon fibers for composites显示文摘 | CHAND S | 2000 | Journal of Material Science2000，35，： | 1 |
| 14 | Eleetroporation-mediated improvement of plant regeneration from colt cherry (Prunus aviumxpseudocerasus ) protoplasts显示文摘 | OCHATT S J CHAND P K DAVEY M R POWER J B | 1988 | Plant Science1988，54，： | 1 |
| 15 | A parts selection model with one-way substitution显示文摘 | Chand S Ward J E Weng Z K | 1994 | European Journal of Operational Research1994，73，11： | 1 |
| 16 | Endothelial nitric oxide synthase single nucleotide polymorphism and left ventricular function in early chronic kidney disease显示文摘 | Chand S Chue CD Edwards NC | 2015 | PLoS One2015，10，01： | 1 |
| 17 | The single-item lot-sizing problem with immediate lost sales 显示文摘 | Aksen D K Altinkemer S Chand | 2003 | European Journal of Operational Research (S0377-2217)2003，147，3： | 1 |
| 18 | Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012显示文摘 | Bermingham A Chand M A Brown C S | 2012 | Eur Surveill2012，17，20： | 1 |
| 19 | An integrated PCR mierofluidic chip incorporating aseptic electrochemical cell ly- sis and capillary electrophoresis amperometric DNA detection for rapid and quantitative genetic analysis 显示文摘 | JHA S K CHAND R HAN D | 2012 | Lab Chip2012，12，21： | 1 |
| 20 | Spatial characterization of electrical power consumption patterns over India using temporal DMSP-OLS night-time satellite data显示文摘 | Chand T R K Badarinath K V S Elvidge C D | 2009 | International Journal of Remote Sensing2009，30，3： | 1 |
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