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| 1 | Targeted therapies in breast cancer:New challenges to fight against resistance显示文摘Breast cancer is the most common type of cancer found in women and today represents a significant challenge to public health. With the latest breakthroughs in molecular biology and immunotherapy, very specific targeted therapies have been tailored to the specific pathophysiology of different types of breast cancers. These recent developments have contributed to a more efficient and specific treatment protocol in breast cancer patients. However, the main challenge to be further investigated still remains the emergence of therapeutic resistance mechanisms, which develop soon after the onset of therapy and need urgent attention and further elucidation. What are the recent emerging molecular resistance mechanisms in breast cancer targeted therapy and what are the best strategies to apply in order to circumvent this important obstacle? The main scope of this review is to provide a thorough update of recent developments in the field and discuss future prospects for preventing resistance mechanisms in the quest to increase overall survival of patients suffering from the disease. | Viviana Masoud Gilles Pagès | 2017 | World Journal of Clinical Oncology2017，8，2： | 13 |
| 2 | Potential role of metabolomics in diagnosis and surveillance of gastric cancer显示文摘Gastric cancer is one of the deadliest cancers worldwide, and is especially prevalent in Asian countries. With such high morbidity and mortality, early diagnosis is essential to achieving curative intent treatment and long term survival. Metabolomics is a new field of study that analyzes metabolites from biofluids and tissue samples. While metabolomics is still in its infancy, there are numerous potential applications in oncology, specifically early diagnosis. Only a few studies in the literature have examined metabolomics' role in gastric cancer. Various fatty acid, carbohydrate, nucleic acid, and amino acid metabolites have been identified that distinguish gastric cancer from normal tissue and benign gastric disease. However, findings from these few studies are at times conflicting. Most studies demonstrate some relationship of cancer cells to the Warburg Effect, in that glycolysis predominates with conversion of pyruvate to lactate. This is one of the most consistent findings across the literature. There is less consistency in metabolomic signature with respect to nucleic acids, lipids and amino acids. In spite of this, metabolomics holds some promise for cancer surveillance but further studies are necessary to achieve consistency and validation before it can be widely employed as a clinical tool. | Angela W Chan Richdeep S Gill Daniel Schiller Michael B Sawyer | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 4 | Adenoma and advanced neoplasia detection rates increase from 45 years of age显示文摘BACKGROUND Colonoscopy is considered a valid primary screening tool for colorectal cancer(CRC). The decreasing risk of CRC observed in patients undergoing colonoscopy is correlated with the adenoma detection rate(ADR). Due to the fact that screening programs usually start from the age of 50, very few data are available on the risk of adenoma between 40 and 49 years. However, the incidence of CRC is increasing in young populations and it is not uncommon in routine practice to detect adenomas or even advanced neoplasia during colonoscopy in patients under 50 years.AIM To compare the ADR and advanced neoplasia detection rate(ANDR) according to age in a large series of patients during routine colonoscopy.METHODS All consecutive patients who were scheduled for colonoscopy were included.Exclusion criteria were as follows: patients scheduled for partial colonoscopy or interventional colonoscopy(for stent insertion or stenosis dilation).Colonoscopies were performed in our unit by a team of 30 gastroenterologists in2016. We determined the ADR and ANDR in each age group in the whole population and in the population with an average risk of CRC(excluding patients with personal or family history of advanced adenoma or cancer).RESULTS6027 colonoscopies were performed in patients with a median age of 57 years(range, 15-96). The ADR and ANDR were 28.6% and 9.7%, respectively, in the whole population. When comparing patients aged 40-44(n = 382) and 45-49 years (n = 515), a strong increase in all parameters from 45 years was observed, with the ADR rising from 9.7% in patients aged 40-44 to 21.2% between 45 and 49(P <0.001) and the ANDR increasing from 3.1% in patients aged 40-44 to 6.4% in those aged 45-49 years(P < 0.03). With regard to patients aged 50-54(n = 849), a statistically significant increase in the ADR and ANDR was not observed between patients aged 45-49 and those aged 50-54 years. In the population with an average risk of CRC, the ADR and ANDR were still significantly higher in patients aged 45-49 compared with those aged 40-44 years.CONCLUSION This study shows a significant two-fold increase in the ADR and ANDR in patients aged 45 years and over. | David Karsenti Gaelle Tharsis Pascal Burtin Franck Venezia Gilles Tordjman Agnès Gillet Joelle Samama Karine Nahon-Uzan Philippe Cattan Maryan Cavicchi | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 5 | High-energy hybrid femtosecond laser system demonstrating 2×10 PW capability显示文摘We report on a two-arm hybrid high-power laser system(HPLS)able to deliver 2×10 PW femtosecond pulses,developed at the Bucharest-Magurele Extreme Light Infrastructure Nuclear Physics(ELI-NP)Facility.A hybrid frontend(FE)based on a Ti:sapphire chirped pulse amplifier and a picosecond optical parametric chirped pulse amplifier based on beta barium borate(BBO)crystals,with a cross-polarized wave(XPW)filter in between,has been developed.It delivers 10 mJ laser pulses,at 10 Hz repetition rate,with more than 70 nm spectral bandwidth and high-intensity contrast,in the range of 1013:1.The high-energy Ti:sapphire amplifier stages of both arms were seeded from this common FE.The final high-energy amplifier,equipped with a 200 mm diameter Ti:sapphire crystal,has been pumped by six 100 J nanosecond frequency doubled Nd:glass lasers,at 1 pulse/min repetition rate.More than 300 J output pulse energy has been obtained by pumping with only 80%of the whole 600 J available pump energy.The compressor has a transmission efficiency of 74%and an output pulse duration of 22.7 fs was measured,thus demonstrating that the dual-arm HPLS has the capacity to generate 10 PW peak power femtosecond pulses.The reported results represent the cornerstone of the ELI-NP 2×10 PW femtosecond laser facility,devoted to fundamental and applied nuclear physics research. | François Lureau Guillaume Matras Olivier Chalus Christophe Derycke Thomas Morbieu Christophe Radier Olivier Casagrande Sébastien Laux Sandrine Ricaud Gilles Rey Alain Pellegrina Caroline Richard Laurent Boudjemaa Christophe Simon-Boisson Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Bertrand De Boisdeffre Petru Ghenuche Andrei Naziru Georgios Kolliopoulos Liviu Neagu Razvan Dabu Ioan Dancus Daniel Ursescu | 2020 | High Power Laser Science and Engineering2020，8，4： | 4 |
| 6 | Is breast conservative surgery a reasonable option in multifocal or multicentric tumors?显示文摘The incidence of multifocal(MF) and multicentric(MC) carcinomas varies widely among clinical studies,depending on definitions and methods for pathological sampling.Magnetic resonance imaging is increasingly used because it can help identify additional and conventionally occult tumors with high sensitivity.However,false positive lesions might incorrectly influence treatment decisions.Therefore,preoperative biopsies must be performed to avoid unnecessary surgery.Most studies have shown higher lymph node involvement rates in MF/MC tumors than in unifocal tumors.However,the rate of local recurrences is usually low after breast conservative treatment(BCT) of MC/MF tumors.It has been suggested that BCT is a reasonable option for MC/MF tumors in women aged 50-69 years,with small tumors and absence of extensive ductal carcinoma in situ.A metaanalysis showed an apparent decreased overall survival in MC/MF tumors but data are controversial.Surgery should achieve both acceptable cosmetic results and negative margins,which requires thorough preoperative radiological workup and localization of lesions.Boost radiotherapy techniques must be evaluated since double boosts might result in increased toxicity,namely fibrosis.In conclusion,BCT is feasible in selected patients with MC/MF but the choice of surgery must be discussed in a multidisciplinary team comprising at least radiologists,surgeons and radiotherapists. | Gilles Houvenaeghel Agnès Tallet Aurélie Jalaguier-Coudray Monique Cohen Marie Bannier Camille Jauffret-Fara Eric Lambaudie | 2016 | World Journal of Clinical Oncology2016，7，2： | 4 |
| 7 | A genetic linkage map of Triticum tauschii(DD) and its relationship to the D genome of bread wheat (AABBDD)显示文摘 | GILL K S LUBBERS E L RAUPP WJ | 1991 | Genome1991，34，： | 2 |
| 8 | Robotic partial nephrectomy: the real benefit显示文摘 | Craig Rogers Shyam Sukumar Inderbir S Gill | 2011 | Current Opinion in Urology2011，，1： | 2 |
| 9 | 无心血管病者尿钠排泄、血压与未来心血管病及死亡风险显示文摘高血压是心血管病的危险因素。代表膳食钠摄入的尿钠排泄增加与血压相关。但在一些观察性研究中,低钠摄入与死亡率增加相关。进一步研究应评估混杂相关性是否能解释钠摄入与预后的关系。研究者分析英国生物银行参加者(n=457484,平均年龄56.3岁,44.7%为男性)尿电解质与血压的数据。采用Kawasaki公式估算每日尿钠排泄量。研究者分析基线无心血管病、治疗的高血压或糖尿病者(n=322624)钠排泄与血压的关系,并评估钠排泄与致死性及非致死性心血管病、心力衰竭及死亡发生率的关系。 | Welsh CE Welsh P Jhund P Delles C Celis-Morales C Lewsey JD Gray S Lyall D Iliodromiti S Gill JMR Sattar N Mark PB 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 10 | Laparoscopic ice slush renal hypothermia for partial nephrectomy:the initial experience显示文摘 | Gill I S Abreu S C Desai M M | 2003 | The Journal of Urology2003，，01： | 2 |
| 11 | Imaging of renovascular hypertension: respective values of renal scintigraphy,renal Doppler US,and MR angiography显示文摘 | GILLES S VINCENT L SOPHIE T | 2000 | Radiographics2000，20，5： | 2 |
| 12 | Protein, lipid, water and caloric contents of immature rainbow trout, Salmo gairdneri, growing at different rates显示文摘 | Weatherley A H Gill H S | 1983 | J Fish Biol1983，23，： | 1 |
| 13 | Anti-allergy properties of fermented foods: an important immunoregulatory mechanism of lactic acid bacteria? 显示文摘 | Cross M L Stevenson L M Gill H S | 2001 | International Immunopharmacology2001，1，： | 1 |
| 14 | Comparison of 1,800 laparoscopic and open partial nephrectomies for single renal tumors显示文摘 | GILL I S KAVOUSSI L R LANE B R | 2007 | J Urol2007，178，1： | 1 |
| 15 | Epidermal growth factor receptor signaling is required for normal ovarian steroidogenesis and oocyte maturation显示文摘 | Jamnongjit M Gill A Hammes S R | 2005 | Proc Natl Acad Sci U S A2005，102，16： | 1 |
| 16 | Automated DNA profiling by fluorescent labeling of PCR product显示文摘 | Sullivan KM Pope S Gill P | 1992 | PCR Methods Appl1992，2，1： | 1 |
| 17 | Advances in Urological Laparoscopy 显示文摘 | Gill I S Clayman R V Medougall E M | 1995 | J Urol1995，154，4： | 1 |
| 18 | Genomic affinities of indivdual chromosomes basedon C- and N-bandign analyses of tetraploid Elymus species and their diploid pogenitor species显示文摘 | Morris K LD Gill B S | 1987 | Genome1987，29，： | 1 |
| 19 | Risks and benefits of hormone replacement therapys:the evidence speaks显示文摘 | Humphries K Gill S | 2003 | CMAJ2003，168，： | 1 |
| 20 | A genetic linkage map of Triticum tauschii(DD) and its relationship to the D genome of bread wheat (AABBDD) 显示文摘 | GILL K S LUBBERS E L RAUPP W J | 1991 | Genome1991，34，： | 1 |
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