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| 1 | 4-1BB signaling activates glucose and fatty acid metabolism to enhance CD8^(+) T cell proliferation显示文摘4-1BB(CD137)is a strong enhancer of the proliferation of CD8^(+)T cells.Since these cells require increased production of energy and biomass to support their proliferation,we hypothesized that 4-1BB signaling activated glucose and fatty acid metabolism.We found that treatment with agonistic anti-4-1BB mAb promoted the proliferation of CD8^(+)T cells in vitro,increasing their size and granularity.Studies with a glycolysis inhibitor and a fatty acid oxidation inhibitor revealed that CD8^(+)T cell proliferation required both glucose and fatty acid metabolism.Anti-4-1BB treatment increased glucose transporter 1 expression and activated the liver kinase B1(LKB1)-AMP-activated protein kinase(AMPK)-acetyl-CoA carboxylase(ACC)signaling pathway,which may be responsible for activating the metabolism of glucose and fatty acids.We also examined whether blocking glucose or fatty acid metabolism affected cell cycle progression and the anti-apoptotic effect of 4-1BB signaling.The increase of anti-apoptotic factors and cyclins in response to anti-4-1BB treatment was completely prevented by treating CD8^(+)T cells with the fatty acid oxidation inhibitor,etomoxir,but not with the glycolysis inhibitor,2-deoxy-D-glucose.We conclude that anti-4-1BB treatment activates glucose and fatty acid metabolism thus supporting the increased demand for energy and biomass,and that fatty acid metabolism plays a crucial role in enhancing the cell cycle progression of anti-CD3-activated CD8^(+)T cells in vitro and the anti-apoptotic effects of 4-1BB signaling on these cells. | Beom K Choi Do Y Lee Don G Lee Young H Kim Seon-Hee Kim Ho S Oh Chungyong Han Byoung S Kwon | 2017 | Cellular & Molecular Immunology2017，14，9： | 6 |
| 2 | 颈总动脉内径与心血管事件及死亡风险研究:4项队列研究的汇总分析显示文摘颈动脉内径增加是动脉重构的表现,且可能是心血管病的危险因素。研究者评估颈动脉内径与脑卒中、冠状动脉性心脏病、心血管病及全因死亡的关系,并探讨与血压有关的中膜增厚、动脉僵硬、动脉壁应力及动脉硬化等动脉重构过程能否解释此关系。 | Sedaghat S van Sloten TT Laurent S London GM Pannier Kavousi M Mattace-Raso F Franco OH Boutouyrie P Ikram MA Stehouwer CDA 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，7： | 4 |
| 3 | Anterior segment congestion of a right liver lobe graft in living-donor liver transplantation and strategy to prevent congestion显示文摘 | SungGyu Lee KwangMin Park Shin Hwang KiHoon Kim ChulSoo Ahn DukBok Moon JungWoo Joo SungHoon Cho KiBong Oh TaeYong Ha HyunSeong Yang KyuTaek Choi KyuSam Hwang EunJoo Lee YoungSang Lee HanJoo Lee YoungHwa Chung MyungHwan Kim SungKoo Lee DongJin Suh KyuBo S | 2003 | Journal of Hepato - Biliary - Pancreatic Surgery2003，，1： | 3 |
| 4 | Pathophysiology and treatment of Barrett's esophagus显示文摘Gastroesophageal reflux disease (GERD) affects an estimated 20% of the population in the United States. About 10%-15% of patients with GERD develop Barrett’s esophagus, which can progress to adenocarcinoma, currently the most prevalent type of esophageal cancer. The esophagus is normally lined by squamous mucosa, therefore, it is clear that for adenocarcinoma to develop, there must be a sequence of events that result in transformation of the normal squamous mucosa into columnar epithelium. This sequence begins with gastroesophageal reflux, and with continued injury metaplastic columnar epithelium develops. This article reviews the pathophysiology of Barrett’s esophagus and implications for its treatment. The effect of medical and surgical therapy of Barrett’s esophagus is compared. | Daniel S Oh Steven R DeMeester | 2010 | World Journal of Gastroenterology2010，16，30： | 2 |
| 5 | 高性能粉末冶金连杆在V6发动机中的应用显示文摘今天,减轻连杆重量对满足现代内燃机的各项要求是至关重要的。为了降低产品成本、改善NVH特性和提高轴瓦的可靠性,现代汽车公司(HMC)已采用粉末冶金锻造连杆取代传统的热锻连杆。通过提高质量和降低成本的优化设计,开发了轻型连杆。值得注意的是,粉末冶金锻造连杆的质量比传统的热锻连杆的质量小17.7%,而且,连杆大头质量比传统型连杆大头的质量小22.5%。采用轻型连杆可减小曲轴系的质量,从而也减小了主要运动件的质量。由于减小了质量,轴瓦可靠性和NVH特性均可提高。HMC在一台新型V6发动机上进行了疲劳、刚度和装机耐久性等对比试验。 | Paek S Y Ryou H S Oh J S 沈永生 | 1999 | 国外内燃机1999，31，5： | 2 |
| 6 | 血根碱对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平以及肉品质的影响显示文摘研究旨在探索日粮添加血根碱(SGV)对肉鸡生长性能、相对器官重量、盲肠菌群、血清胆固醇水平和腿肌丙二醛含量的影响。选用840日龄雄性肉鸡(罗斯品种)饲养于28个稻草垫上,随机分为4个处理:玉米-豆粕型基础对照日粮、基础日粮中添加卑霉素10 ppm作为生长促进剂(AGP)、基础日粮中添加SGV 20 ppm(SGV20)和50 ppm(SGV50)。与饲喂基础日粮的肉鸡相比,基础日粮中添加AGP组、SGV20组和SGV50组的肉鸡最终体重(BW)、日增重、饲料转化率(FCR)显著改善(P<0.05)。与对照组相比,SGV20喂养组的肉鸡相对空肠重量显著降低(P<0.05),所有添加SGV组肉鸡相对空肠或回肠长度显著升高(P<0.05)。SGV20组较对照组肉鸡肠道菌群有所改变,尤其是盲肠乳酸菌数增加,但AGP组无改变。SGV20组或SGV50组肉鸡的总胆固醇水平较对照组显著降低(P<0.05),控制饮食物显著降低(P<0.05)。添加SGV后,作为脂质过氧化反应指示剂的腿肌丙二醛含量显著降低(P<0.05)。研究表明,在肉鸡日粮中补充SGV 20或50 ppm可以提高肉鸡生长性能,改变多种生物和生理参数,如相对器官重量、血清胆固醇水平、肠道菌群和肉品质。 | Lee K W Kim J S Oh S T Kang C W An B K | 2015 | 饲料博览2015，0，3： | 2 |
| 7 | Electrical properties of the 85% Bi2 Te3 - 15% Bi2 Se3 thermoelectric material doped with SbI3 and CuBr显示文摘 | Hyun D B Hwang J S Oh T S | 1998 | J Phys Chem Solids1998，59，67： | 2 |
| 8 | Effect of InterlamellarSpacing on Cementite Dissolution during Wire Drawing ofPearlitic Steel Wires 显示文摘 | Nam W J Bae C M Oh S J | 2000 | Scripta Mater2000，42，： | 2 |
| 9 | Network - based approach to on -line cursive script recognition 显示文摘 | SIN B K HA J Y OH S C | 1999 | IEEE Transaction on System Man and Cybernetics-Part B:Cybernetics1999，29，2： | 2 |
| 10 | Aromatic amino acid catabolism by lactococci显示文摘 | GAO S OH DH BROADBENT J R | 1997 | Lait1997，77，： | 2 |
| 11 | Vagal denervation and atrial fibrillation inducibility: Epicardial fat pad ablation does not have long-term effects 显示文摘 | Oh S Zhang YH Bivevski S | 2006 | Heart Rhythm2006，3，6： | 1 |
| 12 | Identification of three genetic loci controlling leaf senescence in Arabidopsis thaliana显示文摘 | OH S A PARK J H LEE G I PACK K H PARK S K NAM H G | 1997 | Plant Journal1997，12，3： | 1 |
| 13 | Expression of a bifunctional fusion of the Escherichia coli genes for trehalose 6-phosphate synthase and trehalose-6-phosphate phosphatase in transgenic rice plants increases trehalose accumulation and abiotic stress tolerance without stunting growth显示文摘 | Jang I C Oh S J Seo J S | 2003 | Plant Physiology2003，131，2： | 1 |
| 14 | 显示文摘 | Lee T H Oh C S Lee C G | 2004 | Scripta Materialia2004，5，50： | 1 |
| 15 | Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells显示文摘 | Oh M Choi S Chung H | 1999 | Int J Oncol1999，14，5： | 1 |
| 16 | Characteristics of nitrile--butadiene rubber layered silicate nanocomposites with silane coupling agent 显示文摘 | Kim J T Lee D Y Oh T S | 2003 | J Appl Polym Sci2003，89，10： | 1 |
| 17 | Three-axis attitude determination from vector observations显示文摘 | Shuster M D Oh S D | 1981 | Journal of Guidance and Control1981，4，1： | 1 |
| 18 | Electricity generation from swine wastewater using microbialfuel cells显示文摘 | Min B Kim J R Oh S E | 2005 | Water Res2005，39，20： | 1 |
| 19 | A new class of SN2 reactions catalyzed by protic solvents: facile fluorination for isotopic labeling of diagnostic molecules 显示文摘 | Kim D W Ahn D S Oh Y H | 2006 | J Am Chem Soc2006，128，16： | 1 |
| 20 | Significantly accelerated osteoblast cell growth on aligned TiO2 nanotubes 显示文摘 | Oh S Daraio C Chen LH | 2006 | J Biomed Mater Res A2006，78，1： | 1 |
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