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	题名	作者	年代	出处	被引量
1	N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects.	Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea	2008	World Journal of Gastroenterology2008，14，18：	2
2	Mamey sapote cultivars in Florida显示文摘	Campbell C W S P Lara	1982	Processdings of the Florida State Horticultural Society1982，95，：	1
3	显示文摘	Lara Wilfredo C Jeremy S Lewis Rodney P	1998	Journal of Long-Term Effects of Medical Implants1998，8，1：	1
4	Polybrominated diphenyl ether in theEast Asian environment: A critical review显示文摘	Wang Y Jiang G Lara P K S	2007	Environmental Internalion-ai2007，33，：	1
5	Tip dieback of mango (Mangifera indica) caused by Botryosphaeria ribis显示文摘	Ramos L J Lara S P McMillan R T Jr	1991	Plant disease1991，75，：	1
6	Retinoic acid and dexamethasone regulate the expression ofPEDF in retinal and endothelial cells显示文摘	Tombran-Tink J Lara N Apricio SE Potluri P Gee S Ma JX etal	2004	Eocp Eye Res2004，78，5：	1
7	The rpoN gene product of Pseudo-monas aeruginosa is required for expression of diverse genes,inclu-ding the flagellin gene显示文摘	Totten P A Lara J C Lory S		0，，01：	1
8	Folding and intramembraneous brichos binding of the prosuffactant protein C transmembrane segment 显示文摘	Sátenz A Presto J Lara P	2015	J Biol Chem2015，290，17：	1
9	Changes in the oral environment during four stages of orthodontic treatment显示文摘	Lara C E Normam M Leonor S P	2010	Korean J Orthod2010，40，2：	1
10	Chemical compotition of rainwater and anthropogenic influences in the Piracicaba River Basin, Southeast Brazil显示文摘	Lara L B L S Artaxo P Martineili L A	2001	Atmospheric Environment2001，35，：	1
11	Tip dieback of mango (Mangifera indica) caused byBotryosphaeria ribis显示文摘	Ramos L J Lara S P McMillan R T Jr	1991	Plant Disease1991，75，3：	1
12	Stable carbon and nitrogen isotopic composition of bulk aerosol particles in a C4 plant landscape of southeast Brazil显示文摘	MARTINELLI L A CAMARGO P B LARA L B L S	2002	Atmospheric Environment2002，36，14：	1
13	Stable carbon and nitrogen isotopic composition of bulk aerosol particles in a C4 plant landscape of southeast Brazil 显示文摘	Martinelli L A Camargo P B Lara L B L S	2002	Atmospheric Environment2002，36，14：	1
14	Electroreduction of the antioulin- gagent TCMTB and its electroanalytical determination in tannerywastewaters显示文摘	MENESES E S MARIA LARA P M ARGUELHO JOStP HALVES	2005	Talanta2005，67，4：	1
15	High doses of irbesartan offer long - term kidney protection in cases of established diabetic nephropathy显示文摘	Ros- Ruiz S Aranda- Lara P Fernndez JC	2012	Nefrologia2012，32，2：	1
16	Changes in the oral environment during four stages of orthodontic treatment 显示文摘	LARA C E NORMA M M LEONOR S P	2010	Korean J Orthod2010，40，2：	1
17	Electroreduction of the antifoulingagent TCMTB and its electro- analyticaldetermination in tannerywas- tewaters 显示文摘	Meneses E S Arguelho Maria Lara P M Alves Jos6 P H	2005	Talanta2005，67，4：	1
18	Stable carbon and nitrogen isotopic composition of bulk aerosol particles in a C4 plant landscape of southeast Brazil 显示文摘	MartineUi L A Camargo P B Lara L B L S	2002	Atmospheric Environment2002，36，14：	1
19	Electroreduction of the antifouling agent TCMTB and its electroanalytical determination in tannery wastewaters 显示文摘	Elaine S M Maria Lara P M A Jose P H A	2005	Talanta2005，67，4：	1
20	Chemical composition of rainwater and anthropogenic influences in the Piracicaba River Basin, Southeast Brazil 显示文摘	Lara L B L S Artaxob P Martinellia L A	2001	Atmospheric Environment2001，35，：	1

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