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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 3 | Revisions to the Tumor,Node,Metastasis staging of lung cancer(8th edition):Rationale,radiologic findings and clinical implications显示文摘The Tumor, Node, Metastasis(TNM) staging system,adopted by the Union for International Cancer Control(UICC) and the American Joint Committee on Cancer(AJCC), has been recently revised, with the new 8^(th) edition of the staging manual being published in January 2017. This edition has few but important evidencebased changes to the TNM staging system used for lung cancer. Radiologists should be aware of the updated classification system to accurately provide staging information to oncologists and oncosurgeons. In this article, we discuss the rationale, illustrate the changes with relevance to Radiology, and review the clinical implications of the 8^(th) edition of the UICC/AJCC TNM staging system with regards to lung cancer. | Fernando U Kay Asha Kandathil Kiran Batra Sachin S Saboo Suhny Abbara Prabhakar Rajiah | 2017 | World Journal of Radiology2017，9，6： | 39 |
| 4 | 微小RNA-1和微小RNA-29b对急性心肌梗死后不良心室重塑的诊断和预后价值显示文摘已知微小RNA(microRNAs,miRs)在急性心肌梗死(acute myocardial infarction,AMI)临床前期模型中可发挥纤维化和抗纤维化作用。为了评估miR-1,miR-21,miR-29b和miR-92a能否作为患者发生AMI后不良心室重塑(adverse ventricular remodeling,AVR)的循环生物标志物, | 刘莉 叶鹏 Grabmaier U Clauss S Gross L Klier I Franz WM Steinbeck G Wakili R Theiss HD Brenner C | 2017 | 中华高血压杂志2017，25，7： | 17 |
| 5 | 美国乳清蛋白的应用研究和最新进展显示文摘 | U S Dairy Export Council | 1998 | 中国食品添加剂1998，9，3： | 12 |
| 6 | Climate Changes in the 21st Century over the Asia-Pacific Region Simulated by the NCAR CSM and PCM显示文摘The Climate System Model (CSM) and the Parallel Climate Model (PCM), two coupled global climate models without flux adjustments recently developed at NCAR, were used to simulate the 20th century climate using historical greenhouse gas and sulfate aerosol forcing. These simulations were extended through the 21st century under two newly developed scenarios, a business-as-usual case (BAU, CO2≈710 ppmv in 2100) and a CO2 stabilization case (STA550, CO2≈540 ppmv in 2100). The simulated changes in temperature, precipitation, and soil moisture over the Asia-Pacific region (10°-60°N, 55°-155°) are analyzed, with a focus on the East Asian summer monsoon rainfall and climate changes over the upper reaches of the Yangtze River. Under the BAU scenario, both the models produce surface warming of about 3-5℃ in winter and 2-3℃ in summer over most Asia. Under the STA550 scenario, the warming is reduced by 0.5-1.0℃ in winter and by 0.5℃ in summer. The warming is fairly uniform at the low latitudes and does not induce significant changes in the zonal mean Hadley circulation over the Asia-Pacific do- main While the regional precipitation changes from single CSM integrations are noisy, the PCM ensemble mean precipitation shows 10%-30% increases north of ~ 30°N and~10% decreases south of ~ 30°N over the Asia-Pacific region in winter and 10%-20% increases in summer precipitation over most of the region. Soil moisture changes are small over most Asia The CSM single simulation suggests a 30% increase in river runoff into the Three Gorges Dam, but the PCM ensemble simulations show small changes in the | Aiguo Dai, G.A. Meehl, W.M. Washington, and T.M.L. Wigley National Center for Atmospheric Research P.O. Box 3000, Boulder, CO 80307 ) Email: adai@ ucar. edu The National Center for Atmospheric Research is sponsored by the U S National Science Foundation. | 2001 | Advances in Atmospheric Sciences2001，18，5： | 9 |
| 7 | BT型杂交粳稻育性及其三系的若干蛋白质标记(英文)显示文摘用十二烷基硫酸钠聚丙烯酰胺凝胶电泳 (SDS- PAGE)方法 ,对粳稻 BT细胞质雄性不育系六千辛 A,保持系六千辛 B,恢复系六千辛 R、7730 2 - 1,以及杂交组合六千辛 A/7730 2 - 1的 F1 和 F2 种子的胚乳贮藏蛋白进行了分析。结果表明 ,在谷蛋白α- 3区域 ,恢复系有两条带α- 3a和α- 3b,而六千辛 A和六千辛 B只有一条带α- 3。 F2 代具有α- 3的种子和具有α- 3a加α-3b的种子 1∶ 1分离。谷蛋白α- 4带的移动速率 ,恢复系比六千辛 A快。把较快的α- 4带记为α- 4f。 F2 代具有α- 4的种子和具有 α- 4加 α- 4f的种子也是 1∶ 1分离 ,与配子体不育类型的 F2 代花粉育性恢复基因分离比一致。系谱分析表明六千辛 R中 α-3a和α- 3b来源于 IR8。六千辛 A比六千辛 | 洪德林 佐藤光 熊丸敏博 曲乐庆 U S SADAR | 2001 | 中国水稻科学2001，15，3： | 8 |
| 8 | 维生素D对心力衰竭患者全因死亡率的影响:4000U/d维生素D口服3年随机临床试验结果显示文摘循环25-羟基维生素D[25-hydroxyvitamin D,25(OH)D]〈75nmol/L与死亡率风险的非线性增加相关。这种低25(OH)D水平在心力衰竭患者中很常见。因此,Zittermann等进行研究检查口服维生素D补充剂能否降低晚期心力衰竭患者的死亡率。 | 刘莉 叶鹏 Zittermann A Ernst JB Prokop S Fuchs U Dreier J Kuhn J Knabbe C Birschmann I Schulz U Berthold HK Pilz S Gouni-Berthold I Gummert JF Dittrich M Brgermann J | 2017 | 中华高血压杂志2017，25，10： | 7 |
| 9 | Confocal laser endomicroscopy and immunoendoscopy for real-time assessment of vascularization in gastrointestinal malignancies显示文摘Gastrointestinal cancers represent a major cause of morbidity and mortality,with incomplete response to chemotherapy in the advanced stages and poor prognosis.Angiogenesis plays a crucial part in tumor growth and metastasis,with most gastrointestinal cancers depending strictly on the development of a new and devoted capillary network.Confocal laser endomicroscopy is a new technology which allows in vivo microscopic analysis of the gastrointestinal mucosa and its microvascularization during ongoing endoscopy by using topically or systemically administered contrast agents.Targeting markers of angiogenesis in association with confocal laser endomicroscopic examination(immunoendoscopy),as a future challenge,will add functional analysis to the morphological aspect of the neoplastic process.This review describes previous experience in endomicroscopic examination of the upper and lower digestive tract with emphasis on vascularization,resulting in a broad spectrum of potential clinical applications,and also preclinical research that could be translated to human studies. | Dan Ionut Gheonea Tatiana Crtnǎ Tudorel Ciurea Carmen Popescu Anca Bǎdǎrǎu Adrian Sǎftoiu | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 10 | 健康领域的文化能力显示文摘1背景
尽管人类对其他社会的兴趣纵贯历史的各个阶段,但是检验不同文化概念对人类健康实践的影响从20世纪才开始,当时是伴随着长期的人类学田野调查产生的,这些田野调查揭露了不同文化之间相关卫生实践的多样性、复杂性和连续性。 | Napier A D Ancarno C Butler B Calabrese j Chater A Chatterjee H Guesnet F Home R Jacyna S Jadhav S Macdonald A Neuendorf U Parkhurst A Reynolds R Scambler G Shamdasani S Smith S Z Stougaard-Nielsen J Thomson L Tyler N Volkmann A M Walker T Watson J Williams AC Willott C Wilson J Woolf K | 2016 | 中国卫生政策研究2016，9，2： | 5 |
| 11 | 界面压力可控式假肢接受腔设计显示文摘功能性假肢接受腔需要同时具备穿戴舒适性与力及运动的传递功能,两者对人机界面提出刚柔特性相反的要求,对接受腔的设计形成了矛盾。针对这一矛盾,提出分时间歇和分区交替承载的界面压力可控式假肢接受腔设计概念,以最大化其功能传递性,并且避免残肢软组织长时间承受过高载荷。设计一种负刚度挤压腔体单元,通过抽真空方式驱动腔体单元收缩改变接受腔内壁形状,实现接受腔对残肢软组织适配界面的刚柔特性协调及快速转换。理论分析负刚度挤压腔体单元的力学特性,该特性使其对软组织松紧挤压转换所需的驱动力小,有利于小型化驱动单元,同时也使接受腔对软组织具有过载保护的功能。以该单元为基础构建假肢接受腔试验模型,并对其界面压力响应特性进行试验评价,初步实现了对接受腔界面压力的控制,并证明了该设计方案可以同时提高接受腔的功能传递性和舒适安全性。 | 甘云 | 2013 | 机械工程学报2013，49，11： | 5 |
| 12 | 稻田CH_4排放及控制技术的研究(英文)显示文摘为了探索北方稻田水管理、施肥和水稻品种对稻田甲烷排放的影响 ,于 1995年至 1998年应用全自动甲烷采样 -测定系统 ,测定了水稻田甲烷排放通量。实验探明 :北方稻田甲烷排放通量为 4~364mg/m2 .d,平均值为 82 mg/m2 .d;稻田甲烷的季节排放只有一个高峰 ,发生在水稻分蘖期 ,该期的甲烷排放量占年排放总量的 85 %以上 ,水稻生长中、后期的稻田甲烷非常有限。水管理对稻田甲烷的生成、排放有显著的影响 ,稻田采用间歇灌溉代替常规灌溉和淹灌 ,可减排稻田甲烷 4 6%~ 5 9% ;稻田施用有机肥 ,甲烷排放量则剧增。但在同等有机碳含量情况下 ,不同有机肥的产甲烷潜势存在明显差异 ,猪粪和稻草较高 ,堆肥和牛粪较低 ,稻田施用堆肥和牛粪 ,可比施用猪粪和稻草的稻田减排稻田甲烷 72 %~ 90 % ;试验中选用的水稻品种 ,以中作 93的甲烷排放效率为最低 ,其甲烷排放通量比杂交稻京优和高秆品种中花 94 - 10 17减少 5 0 %~ 5 5 %。实验揭示 ,水稻分蘖期是控制北方稻田甲烷排放的关键时期 。 | 王增远 徐雨昌 李震 过益先 R Wassmann H U Neue R S Lantin L V Buendia | 2001 | 作物学报2001，27，6： | 5 |
| 13 | 氧化铝对铁矿石烧结质量和生产率的影响(英文)显示文摘烧结矿是现代高炉生产的主要含铁原料。合理控制入炉烧结矿的理化性能与冶金性能对高炉生产和稳定操作是很必要的。铁矿粉是烧结矿的主要原料,其化学成分和烧结料层内的热量条件在烧结过程中起着重要的作用。化学成分等参数也决定着烧结矿矿相结构和质量。由于含氧化铝原料的低反应性及其液相的高粘性,因此在人们的预料中高铝矿石对烧结矿结构组成的影响并不好。烧结混合料中的氧化铝在同化过程中需要消耗大量热量,延迟烧结过程。在确保高炉渣的流动性方面,氧化铝也需要消耗较大热量。不论是烧结还是高炉的生产实绩均表明,氧化铝是有害的。一般而言,高含铁量与低脉石的印度矿与其他矿石的不同特点就是氧化铝含量高。由于高品味铁矿石的消耗殆尽,使用可利用的烧结原料成为生产必需。因此,必须要掌握氧化铝的作用及其对烧结矿质量和生产过程的影响。实验室完成了不同氧化铝含量水平(2.00%~5.46%)的实验,可从中了解氧化铝在烧结矿矿物学、生产率、物理性能和冶金性能方面的影响。随着烧结矿中氧化铝含量的增加,残存赤铁矿、复合铁酸钙(SFCA)和孔隙率增加,而磁铁矿和硅酸盐比例下降。烧结生产率和烧结矿转鼓强度(TI)随着氧化铝含量上升而下降,反映烧结矿冶金性能的诸如低温还原粉化率(RDI)和还原率(RI)提高。 | T Umadevi S Prakash U K Bandopadhyay P C Mahapatra M Prabhu Madhu Ranjan | 2010 | 世界钢铁2010，，1： | 4 |
| 14 | Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy显示文摘AIM: To evaluate the association between serum concentrations of S100β in patients with cirrhosis and the presence of low grade hepatic encephalopathy(HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy(CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney's U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100β values were different among all groups, and differences remained significant between groups 1 and 2(P < 0.001), and also between groups 2 and 3(P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100β was higher than in patients without HE [0.18(0.14-0.28) ng/m L vs 0.11(0.06-0.14) ng/m L, P < 0.001]. There was a close correlation between serum concentrations of S100β and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE(r =-0.413, P = 0.019). ROC curve analysis yielded > 0.13 ng/m L as the best cutoff value of S100β for the diagnosis of HE(sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100β are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100β could help in the correct characterization of incipient stages of HE. | Andrés Duarte-Rojo Astrid Ruiz-Margáin Ricardo U Macias-Rodriguez Francisco Javier Cubero José Estradas-Trujillo Rosa Ma Munoz-Fuentes Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，17： | 4 |
| 15 | Complications of diagnostic and therapeutic ERCP: a prospective multicenter study显示文摘 | E Masci G Toti A Mariani S Curioni A Lomazzi M Dinelli G Minoli C Crosta U Comin A Fertitta A Prada G Rubis Passoni P.A Testoni | 2001 | The American Journal of Gastroenterology2001，，2： | 4 |
| 16 | Investigation of soliton solutions with different wave structures to the(2+1)-dimensional Heisenberg ferromagnetic spin chain equation显示文摘The principal objective of this article is to construct new and further exact soliton solutions of the(2+1)-dimensional Heisenberg ferromagnetic spin chain equation which investigates the nonlinear dynamics of magnets and explains their ordering in ferromagnetic materials.These solutions are exerted via the new extended FAN sub-equation method.We successfully obtain dark,bright,combined bright-dark,combined dark-singular,periodic,periodic singular,and elliptic wave solutions to this equation which are interesting classes of nonlinear excitation presenting spin dynamics in classical and semi-classical continuum Heisenberg systems.3D figures are illustrated under an appropriate selection of parameters.The applied technique is suitable to be used in gaining the exact solutions of most nonlinear partial/fractional differential equations which appear in complex phenomena. | M S Osman K U Tariq Ahmet Bekir A Elmoasry Nasser S Elazab M Younis Mahmoud Abdel-Aty | 2020 | Communications in Theoretical Physics2020，72，3： | 4 |
| 17 | Association of Helicobacter pylori IgA antibodies with the risk of peptic ulcer disease and gastric cancer显示文摘AIM: To compare the prevalence of Helicobacter pylori (Hpylori) IgG and IgA antibodies between adult subjects,with defined gastric diseases, nondefined gastric disorders and those representing the population.METHODS: Data on H pylori IgG and IgA antibodies,determined by enzyme immunoassay, were analyzed in 3 252 subjects with DGD including 482 patients with gastric ulcer, 882 patients with duodenal ulcer, 1 525patients with chronic gastritis only and 363 subjects with subsequent gastric cancer, 19 145 patients with NoDg and4 854 POPUL subjects. The age-adjusted prevalences were calculated for 1- and 20-year age cohorts.RESULTS: The prevalences of IgG antibodies were equally high (89-96%) in all 20-year age cohorts of the DGD groups, whereas the prevalences of IgG antibodies were lower and increased by age in the POPUL and NoDg groups. The prevalences of IgA antibodies were also higher in the DGD groups; among them CA (84-89%) and GU groups (78-91%) showed significantly higher prevalences than DU (68-77%) and CG patients (59-74%) (OR 2.49, 95%CI 1.86-3.34 between the GU and DU groups). In the CA, GU, and DU groups, the IgA prevalences showed only minor variation according to age, while they increased by age in the CG, POPUL, and NoDg groups (P≤0.0001). The IgA response, but not the IgG response, was associated with an increased risk of CA (OR 2.41, 95%CI 1.79-3.53) and GU (OR 2.57,95%CI 1.95-3.39) in comparison with CG patients.CONCLUSION: An IgA antibody response during H pylori infection is significantly more common in CA and GU patients as compared with CG patients. | Timo U Kosunen Kari Seppl Seppo Sarna Arpo Aromaa Paul Knekt Jarmo Virtamo Anniina Salomaa-Rsnen Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，43： | 3 |
| 18 | 系统性药物治疗儿童银屑病的安全性显示文摘银屑病是一种常见的慢性炎症性皮肤病。成年人的发病率为2%~3%,其中大约有三分之一的患者在18岁之前发病。在儿童期,该病的发病率呈线性增长。从1970年至2000年,儿童银屑病的发病率增加了一倍多。尽管对许多轻度银屑病患儿而言,局部治疗已足够,但对更多可能影响生活质量的重度或顽固性的银屑病患儿,则往往需要系统性治疗。 | bronckers imgj seyger mmb west dp lara-corrales i tollefson m tom wl hogeling m belazarian l zachariae c mahé e siegfried e philipp s szalai z vleugels ra holland k murphy r baselga e cordoro k lambert j alexopoulos a mrowietz u kievit w paller as 邓婕(编译) 张锡宝(审校) 无 | 2017 | 皮肤性病诊疗学杂志2017，24，5： | 3 |
| 19 | 欧洲和中国的心脏与肾脏远程缺血预适应研究:一项随机对照试验显示文摘远程缺血预适应(remote ischemic preconditioning,RIPC)对经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后造影剂肾病(contrast-induced nephropathy,CIN)的潜在保护作用尚待确定。该研究为双盲、随机、安慰剂对照的多中心研究,纳入年龄〈85岁,肾清除率为30~60mL/(min·1.73m^2)的有临床适应证的患者,除了直接PCI外均按1∶1给予RIPC或标准治疗。主要终点是CIN的发生率。次要终点是围手术期心肌梗死(peri-procedural myocardial infarction,PMI)的发生率。 | 刘青 叶鹏 Moretti C Cerrato E Cavallero E Lin S Rossi ML Picchi A Sanguineti F Ugo F Palazzuoli A Bertaina M Presbitero P Shao-Liang C Pozzi R Giammaria M Limbruno U Lefèvre T Gasparetto V Garbo R OmedèP Sheiban I Escaned J Biondi-Zoccai G Gaita F Perl L D'Ascenzo F | 2018 | 中华高血压杂志2018，26，4： | 3 |
| 20 | The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma(英文)显示文摘Primary central nervous system lymphomas (PCNSL) frequently reveal genomic instability. We analysed different functional genetic variants affecting the folate and homocysteine metabolism important for DNA integrity in 31 PCNSL patients and 142 controls. We found significantly less carriers of the methionine synthase c. 2756A> G (D919G) missense polymorphism among the patients (0.16 vs 0.42; odds ratio 0.26, CI(95%): 0.09-0.74; P=0.005), suggesting a protective function of the G allele. These data stimulate further epidemiological and functional studies focusing on the role of homoeysteine and folate metabolism in lymphoma tumorigenesis. | Linnebank M Schmidt S Kolsch H Linnebank A Heun R Schmidt-Wolf IG Glasmacher A Fliessbach K Klockgether T Schlegel U Pels H | 2004 | 中国神经肿瘤杂志2004，2，2： | 3 |
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