| 1 | Sulphur Mustard Induced Oxidative Stress and Its Prevention by Sodium 2, 3-Dimercapto Propane Sulphonic Acid (DMPS) in Mice显示文摘Sulphur mustard [bis(2 chloro ethyl) sulfide] (SM), a bifunctional alkylating agent has been frequently used as a chemical warfare agent. In the present study, the effects of sodium 2 3 dimercaptopropane sulphonic acid (DMPS) on some biochemical and histological parameters in mice, exposed to 1/4LC 50 concentration of SM vapor (10.5 mg/m\+3) were examined over a period of seven days. Exposure of SM resulted in a significant loss of blood, hepatic and pulmonary glutathione (GSH) and an elevation of hepatic and pulmonary oxidized glutathione (GSSG). These biochemical changes were accompanied by a number of histopathological alterations. The most prominent was congestion and degeneration in viscera and obliteration of chromatin material. These biochemical and histopathological changes were less marked in animals pre administered with DMPS followed by DMPS exposure indicating some protective value of the thiol (DMPS) against SM induced oxidative injury in mice. | S.C.PANT R.VIJAYARAGHAVAN 等 | 2000 | Biomedical and Environmental Sciences2000，13，3： | 4 |
| 2 | Sarin Induced Lung Pathology and Protection by Standard Therapy Regime显示文摘The effects of atropine,diazepam and pralidoxime were studied for their ability to block the pathological lesions induced by sarin.Rats were exposed to and aerosol of sarin at a concentration of 51.2mg·m^-3 for 15 min following the pretreatment with one of th following combinations:atropine(10mg/kg,i.m.)and dizaepam(0.5mg/kg,i.m.);atropine and pralidoxine(25mg/kg,i.m.);diazepam and pralidoxime;atropine,diazepam and pralidoxime.Lung exposed to sarin aerosols revealed and increased cellular proliferation with progressive diffused interstitial thickening on the 4th day following exposure.On the 16th day,loss of alveolar space and consolidation of large areas of all lobes were observed.Sarin also caused damage to the respiratory bronchioles.All the therap regime blocked the development of lung lesions in the descending orders:atropine,diazepam and pralidoxime,atropine and diazepam>diazepam and pralidoxime>atropine and pralidoxime.The result suggests that diazepam in combination with atropine and pralidoxime could be an effective drug combination regime for the lung lesions. | S.C.PANT R.VIJAYARAGHAVAN S.DASGUPTA | 1993 | Biomedical and Environmental Sciences1993，6，2： | 2 |
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