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| 1 | Expression of miR-15/107 Family MicroRNAs in Human Tissues and Cultured Rat Brain Cells显示文摘The miR-15/107 family comprises a group of 10 paralogous microRNAs(miRNAs),sharing a 50AGCAGC sequence.These miRNAs have overlapping targets.In order to characterize the expression of miR-15/107 family miRNAs,we employed customized TaqMan Low-Density micro-fluid PCR-array to investigate the expression of miR-15/107 family members,and other selected miRNAs,in 11 human tissues obtained at autopsy including the cerebral cortex,frontal cortex,primary visual cortex,thalamus,heart,lung,liver,kidney,spleen,stomach and skeletal muscle.miR-103,miR-195 and miR-497 were expressed at similar levels across various tissues,whereas miR-107 is enriched in brain samples.We also examined the expression patterns of evolutionarily conserved miR-15/107 miRNAs in three distinct primary rat brain cell preparations(enriched for cortical neurons,astrocytes and microglia,respectively).In primary cultures of rat brain cells,several members of the miR-15/107 family are enriched in neurons compared to other cell types in the central nervous system(CNS).In addition to mature miRNAs,we also examined the expression of precursors(pri-miRNAs).Our data suggested a generally poor correlation between the expression of mature miRNAs and their precursors.In summary,we provide a detailed study of the tissue and cell type-specific expression profile of this highly expressed and phylogenetically conserved family of miRNA genes. | Wang-Xia Wang Robert J.Danaher Craig S.Miller Joseph R.Berger Vega G.Nubia Bernard S.Wilfred Janna H.Neltner Christopher M.Norris Peter T.Nelson | 2014 | Genomics, Proteomics & Bioinformatics2014，12，1： | 9 |
| 2 | The Press as a Watchdog for Accounting Fraud显示文摘 | GREGORY S.MILLER | 2006 | Journal of Accounting Research2006，，5： | 5 |
| 3 | Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone显示文摘Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody(mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid(LTA). Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immuno PET imaging in an in vivo mouse model of prosthetic joint infection(PJI). In vitro and ex vivo binding of the anti-LTA mAb to pathogenic bacteria was measured with Octet, ELISA, and flow cytometry. The in vivo PJI mouse model was assessed using traditional imaging modalities, including positron emission tomography(PET) with [^(18)F]FDG and [^(18)F]Na F as well as X-ray computed tomography(CT), before being evaluated with the zirconium-89-labeled antibody specific for LTA([^(89)Zr]SAC55).The anti-LTA mAb exhibited specific binding in vitro to LTA-expressing bacteria. Results from imaging showed that our model could reliably simulate infection at the surgical site by bioluminescent imaging, conventional PET tracer imaging, and bone morphological changes by CT. One day following injection of both the radiolabeled anti-LTA and isotype control antibodies, the anti-LTA antibody demonstrated significantly greater(P < 0.05) uptake at S. aureus-infected prosthesis sites over either the same antibody at sterile prosthesis sites or of control non-specific antibody at infected prosthesis sites. Taken together, the radiolabeled anti-LTA mAb, [^(89)Zr]SAC55, may serve as a valuable diagnostic molecular imaging probe to help distinguish between sterile inflammation and infection in the setting of PJI. Future studies are needed to determine whether these findings will translate to human PJI. | Julie E.Pickett John M.Thompson Agnieszka Sadowska Christine Tkaczyk Bret R.Sellman Andrea Minola Davide Corti Antonio Lanzavecchia Lloyd S.Miller Daniel LJ Thorek | 2018 | Bone Research2018，6，2： | 3 |
| 4 | Geodynamics of oceanic plateau and plume head accretion and their role in Phanerozoic orogenic systems of China显示文摘We present three 3D numerical models of deep subduction where buoyant material from an oceanic plateau and a plume interact with the overriding plate to assess the influence on subduction dynamics,trench geometry,and mechanisms for plateau accretion and continental growth.Transient instabilities of the convergent margin are produced,resulting in:contorted trench geometry;trench migration parallel with the plate margin;folding of the subducting slab and orocline development at the convergent margin;and transfer of the plateau to the overriding plate.The presence of plume material beneath the oceanic plateau causes flat subduction above the plume,resulting in a 'bowed' shaped subducting slab.In plateau-only models,plateau accretion at the edge of the overriding plate results in trench migration around the edge of the plateau before subduction is re-established directly behind the trailing edge of the plateau.The plateau shortens and some plateau material subducts.The presence of buoyant plume material beneath the oceanic plateau has a profound influence on the behaviour of the convergent margin.In the plateau + plume model,plateau accretion causes rapid trench advance.Plate convergence is accommodated by shearing at the base of the plateau and shortening in the overriding plate.The trench migrates around the edge of the plateau and subduction is re-established well behind the trailing edge of the plateau,effectively embedding the plateau into the overriding plate.A slab window forms beneath the accreted plateau and plume material is transferred from the subducting plate to the overriding plate through the window.In all of the models,the subduction zone maintains a relatively stable configuration away from the buoyancy anomalies within the downgoing plate.The models provide a dynamic context for plateau and plume accretion in Phanerozoic accretionary orogenic systems such as the East China Orogen and the Central Asian Orogen(Altiads),which are characterised by accreted ophiolite complexes with diverse geochemical affinities,and a protracted evolution of accretion of exotic terranes including oceanic plateau and terranes with plume origins. | Peter G.Betts Louis Moresi Meghan S.Miller David Willis | 2015 | Geoscience Frontiers2015，6，1： | 2 |
| 5 | Resistance training alters skeletal muscle structure and function in human heart failure: effects at the tissue, cellular and molecular levels显示文摘 | Michael J.Toth Mark S.Miller PeterVanBuren Nicholas G.Bedrin Martin M.LeWinter Philip A.Ades Bradley M.Palmer | 2012 | The Journal of Physiology2012，，： | 1 |
| 6 | Earnings Performance and Discretionary Disclosure显示文摘 | Gregory S.Miller | 2002 | Journal of Accounting Research2002，，1： | 1 |
| 7 | The Press as a Watchdog for Accounting Fraud显示文摘 | GREGORY S.MILLER | 2006 | Journal of Accounting Research2006，，5： | 1 |
| 8 | Earnings Performance and Discretionary Disclosure显示文摘 | Gregory S.Miller | 2002 | Journal of Accounting Research2002，，1： | 1 |
| 9 | The Role of Supplementary Statements with Management Earnings Forecasts显示文摘 | Amy P.Hutton Gregory S.Miller Douglas J.Skinner | 2003 | Journal of Accounting Research2003，，5： | 1 |
| 10 | Mortality of Amur tigers:The more things change,the more they stay the same显示文摘Poaching as well as loss of habitat and prey are identified as causes of tiger population declines.Although some studies have examined habitat requirements and prey availability,few studies have quantified cause-specific mortality of tigers.We used cumulative incidence functions(CIFs)to quantify cause-specific mortality rates of tigers,expanding and refining earlier studies to assess the potential impact of a newly emerging disease.To quantify changes in tiger mortality over time,we re-examined data first collected by Goodrich et al.(2008;study period 1:1992–2004)as well as new telemetry data collected since January 2005(study period 2:2005–2012)using a total of 57 tigers(27 males and 30 females)monitored for an average of 747 days(range 26–4718 days).Across the entire study period(1992 to 2012)we found an estimated average annual survival rate of 0.75 for all tigers combined.Poaching was the primary cause of mortality during both study periods,followed by suspected poaching,distemper and natural/unknown causes.Since 2005,poaching mortality has remained relatively constant and,if combined with suspected poaching,may account for a loss of 17–19%of the population each year.Canine distemper virus(CDV)may be an additive form of mortality to the population,currently accounting for an additional 5%.Despite this relatively new source of mortality,poaching remains the main threat to Amur tiger survival and,therefore,population growth. | Hugh S.ROBINSON John M.GOODRICH Dale G.MIQUELLE Clayton S.MILLER Ivan V.SERYODKIN | 2015 | Integrative Zoology2015，10，4： | 1 |
| 11 | The Press as a Watchdog for Accounting Fraud显示文摘 | GREGORY S.MILLER | 2006 | Journal of Accounting Research2006，，5： | 1 |
| 12 | Radiation-induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation显示文摘Translational animal models for oral mucositis(OM)are necessary to simulate and assess the bioclinical effects and response in humans.These models should simulate high levels of radiation exposure that leads to oxidative stress and inflammatoryinitiated tissue changes.Hamster models have been extensively studied to observe pathological effects of radiation exposure and help in the development of effective treatments.To successfully evaluate the potential for treatment regimens with consistency and relevance,a radiation-induced OM hamster model was developed using a clinical linear accelerator utilized by cancer patients daily.The dose exposure to the isolated,everted cheek pouch of a hamster,as well as the progression of injury,proinflammatory marker,histological,and elasticity analyses of the buccal pouch were conducted to verify replicability and reproducibility of the injury model.The findings from this model demonstrated its ability to consistently induce injury and resolution over 28 days using an acute dose of 60 Gy.This model was developed to enhance clinical relevance when evaluating potential efficacious treatments and can now be utilized in efficacy studies to better evaluate developed therapeutics in a preclinical model that is easy to translate to clinical studies.. | Carolyn T.Jordan Emily M.Bradford Dennis C.Cheek Mahesh Kudrimoti Craig S.Miller Molly H.Smith J.Zach Hilt Thomas D.Dziubla | 2021 | Animal Models and Experimental Medicine2021，4，1： | 1 |
| 13 | 用甲基化的寡聚核苷酸作反义制剂显示文摘在含甲基磷酸根的寡核苷酸中,核苷酸之间含有非离子键,能抵抗细胞核酸酶的降解。一这种寡聚物能被培养的哺乳动物细胞完全吸收,它们能与细胞或病毒mRNA的启始密码或编码区或前体RNA的拼接位点有效的结合,特异性地抑制mRNA在细胞中表达。在甲基磷酸根寡核苷酸上衍生与靶mRNA共价交联的功能团,可以增强这种反义寡聚物的效率。这种寡聚核苷酸类似物是研究和控制基因表达的有用工具,并有希望开发成为治疗制剂。 最近。 | Paul S.Miller 熊克勇 | 1992 | 生物工程进展1992，12，2： | 1 |
| 14 | Review of research methodologies for tigers:Telemetry显示文摘Over the past half century,wildlife research has relied on technological advances to gain additional insight into the secretive lives of animals.This revolution started in the 1960s with the development of radio telemetry and continues today with the use of Global Positioning System(GPS)-based research techniques.In the present paper we review the history of radio telemetry from its origins with grizzly bears in Yellowstone to its early applications in tiger research and conservation in Asia.We address the different types of data that are available using radio telemetry as opposed to using other research techniques,such as behavioral observations,camera trapping,DNA analysis and scat analysis.In the late 1990s,the rapid development of GPS collar technology revolutionized wildlife research.This new technology has enabled researchers to dramatically improve their ability to gather data on animal movements and ecology.Despite the ecological and conservation benefits of radio telemetry,there have been few telemetry studies of tigers in the wild,and most have been on the Bengal or Amur subspecies.We close with an assessment of the current tiger conservation efforts using GPS technology and discuss how this new information can help to preserve tigers for future generations. | Clayton S.MILLER Mark HEBBLEWHITE John M.GOODRICH Dale G.MIQUELLE | 2010 | Integrative Zoology2010，5，4： | 0 |
| 15 | Antiproliferative Triterpenoid Saponins from Leptaulus citroides Baill. from the Madagascar Rain Forest显示文摘Bioassay-guided fractionation of EtOH extracts obtained from the roots and wood of the Madagascan plant Leptaulus citroides Baill.(Cardiopteridaceae)led to the isolation of ethyl esters of three new triterpenoid saponins(1–3)and the known sesquiterpenoid cinnamosmolide(4).The structures of 1–3 were elucidated by extensive 1D and 2D NMR experiments and mass spectrometry.Compounds 1,2,and 4 showed moderate cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 2.8,10.2 and 2.0 lM,respectively. | Qingxi Su Peggy J.Brodie Yixi Liu James S.Miller Naina M.Andrianjafy Rabodo Antsiferana Vincent E.Rasamison David G.I.Kingston | 2016 | Natural Products and Bioprospecting2016，6，1： | 0 |
| 16 | 药箱之外显示文摘“谁有绷带?”一个声音在宿舍走廊里回响。在进入大学的第一周,我们都经历着“忘这忘那”的时期。之前,我就忘记了带零食作宵夜。很明显,有个手忙脚乱的可怜女孩忘了带绷带。我们都感受到了一点背井离乡的不适。 | Jacllyn S.Miller 陈梓 | 2013 | 高中生(作文)2013，，11： | 0 |
| 17 | 哈佛大学商学院 怎样通过媒体与投资者沟通显示文摘在公司危急关头,管理层在与投资者进行公司财务状况沟通时,通常会低估媒体的作用。我曾与沃顿商学院的布瑞·布希收集了在纳斯达克和柜台市场(OTC market)交易的200多家公司的数据,研究发现大部分中、小规模的公司都为一事所困扰——自己不在分析师的研究之列。 | Gregory S.Miller | 2008 | 董事会2008，，7： | 0 |
| 18 | 一种用于递送酸度敏感大分子到小肠的简易且廉价的肠溶胶囊(英文)显示文摘目的:通过开展胃肠道远端释放药物的研究,以增加对肠道健康和发病机制的理解。创新点:本研究选择了13C醋酸钠作为同位素探针,通过收集和分析呼吸中的13CO2来非侵入测量其在小肠吸收的情况。这将提供胃排空率的信息及释放和吸收位点的指标。方法:在一系列体外和体内的猪实验中,评估了EUDRAGITL100-55和DRcaps两种胶囊的肠溶保护特性。结论:包覆有EUDRAGITL100-55的DRcaps具有增强的肠溶保护性能,特别是在体内。本研究增加了对猪胃排空的了解,同时也开始设计用于递送酸度敏感大分子到小肠的简易且廉价的肠溶胶囊。 | Darren S.MILLER Anne Michelle PARSONS John BRESL Paul HERDE Duc Minh PHAM Angel TAN Hung-yao HSU Clive A.PRESTIDGE Tim KUCHEL Rezaul BEGG Syed Mahfuzul AZIZ Ross N.BUTLER | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，7： | 0 |
| 19 | Promoting T and NK cell attack: preserving tumor MICA/B by vaccines显示文摘The activating receptor NKG2D, first discovered in the late 1990’s, participates in the immune surveillance of cytotoxic lymphocytes through recognition of the stress-induced ligands MICA/B on the surface of malignant cells. Recently, a study by Badrinath et al. in Nature described a vaccine targeting approach that prevents proteolytic cleavage of MICA/B, leading to enhanced immune infiltration and antitumor responses highlighting the importance of NKG2D interactions on both natural killer cells and T cells. | Frank Cichocki Jeffrey S.Miller | 2022 | Cell Research2022，32，11： | 0 |
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