维普中文期刊产品整合服务
2篇 您的检索式:作者名="S.Zdravkovic"
    题名 作者 年代 出处 被引量
1Nitric oxide and tumour necrosis factor alpha in the process of pseudoexfoliation glaucoma显示文摘AIM: To establish the role of nitric oxide(NO), ascorbic acid and tumour necrosis factor α(TNF-α) in the pathogenesis of pseudoexfoliation glaucoma(XFG).METHODS: Our study included 120 patients who were referred for cataract surgery. All patients were divided into four groups according to clinical findings: XFG,early and late pseudoexfoliation syndrome(XFS), and cataract(without pseudoexfoliation). Serum and aqueous humour levels of the ascorbic acid, NO and TNF-α were measured. The concentrations of the ascorbic acid and NO were measured by an appropriate spectrophotometric method. Enzyme-linked immunosorbent assay(ELISA)was used to determine TNF-α level.RESULTS: Aqueous humour concentration of ascorbic acid was significantly lower in patients with late XFS(0.61 ±0.11 mmol/L) and XFG(0.48 ±0.15 mmol/L)compared to patients with early XFS(0.9 ±0.15 mmol/L)and cataract(1.16 ±0.22 mmol/L), while there was no difference in serum concentration in all examined groups.Aqueous humour concentration of NO was significantly higher in patients with XFG(77.7 ±11.4 μmol/L) compared to patients with early XFS(50.27 ±9.34 μmol/L) and cataract(49.77 ±7.1 μmol/L), while serum concentration was increased in the early stage of XFS(73.26±8.29 μmol/L).Aqueous humour level of proinflammatory cytokine TNF-αwas increased in patients with XFS(early 460.04±18.32 pg/mL;late 502.42±53.23 pg/mL) and XFG(510.34±43.07 pg/mL),while there was no difference in serum level in all examined groups of patients.CONCLUSION: Reduced ascorbic acid and elevated NO and inflammation related cytokine TNF-α level in aqueous humour of the patients with developed XFG suggest that oxidative stress induces local inflammation.Tatjana S.Sarenac Vulovic Sladjana M.Pavlovic Vladimir LJ.Jakovljevic Katarina B.Janicijevic Nemanja S.Zdravkovic 2016International Journal of Ophthalmology(English edition)2016,9,8:2
2Heritability of death from coronary heart disease: a 36‐year follow‐up of 20?966 Swedish twins显示文摘S.Zdravkovic A.Wienke N. L.Pedersen M. E.Marenberg A. I.Yashin U.De Faire 2002Journal of Internal Medicine2002,,:1
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费