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| 1 | Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study显示文摘To determine the interdependence of intracranial pressure(ICP) and intraocular pressure(IOP) and how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into the left ventricle, lumbar cistern, optic nerve subarachnoid space in the left eye, and anterior chamber in the left eye. This allowed ICP, lumbar cistern pressure(LCP), optic nerve subarachnoid space pressure(ONSP) and IOP to be simultaneously recorded. After establishing baseline pressure levels, pressure changes that resulted from lowering ICP(via shunting cerebrospinal fluid(CSF) from the ventricle) were recorded. At baseline, all examined pressures were different(ICP>LCP>ONSP), but correlated(P<0.001). As ICP was lowered during CSF shunting, IOP also dropped in a parallel time course so that the trans-lamina cribrosa gradient(TLPG) remained stable(ICP-IOP dependent zone). However, once ICP fell below a critical breakpoint, ICP and IOP became uncoupled and TLPG changed as ICP declined(ICP-IOP independent zone). The optic nerve pressure gradient(ONPG) and trans-optic nerve pressure gradient(TOPG) increased linearly as ICP decreased through both the ICP-IOP dependent and independent zones. We conclude that ICP and IOP are coupled in a specific pressure range, but when ICP drops below a critical point, IOP and ICP become uncoupled and TLPG increases. When ICP drops, a rise in the ONPG and TOPG creates more pressure and reduces CSF flow around the optic nerve. This change may play a role in the development and progression of various ophthalmic and neurological diseases, including glaucoma. | Ruowu Hou Zheng Zhang Diya Yang Huaizhou Wang Weiwei Chen Zhen Li Jinghong Sang Sumeng Liu Yiwen Cao Xiaobin Xie Ruojing Ren Yazhuo Zhang Bernhard A. Sabel Ningli Wang | 2016 | Science China(Life Sciences)2016，59，5： | 11 |
| 2 | Controlled syn-thesis of poly(ε-caprolactone)-grafted dextran copolymers as poten-tial environmentally friendly surfactants显示文摘 | Sabelle Ydens Delphine Rutot Philippe Deg e | 2000 | Macromolecules2000，33，： | 2 |
| 3 | RhoC-GTPase is a novel tissue biomarker associated with biologically aggressive carcinomas of the breast显示文摘 | Kleer C G Griffith K A Sabel M S | 2005 | Breast Cancer Res Treat2005，93，2： | 1 |
| 4 | Long-term stability of PBCA nanoparticle suspensions显示文摘 | Sommerfeld P Sabel B A Schroeder U | 2000 | J Microencapsul2000，17，： | 1 |
| 5 | Oligodendroglial tumors:refinement of candidate regions on chromosome arm 1p and correlation of 1p/19q status with survival显示文摘 | Felsberg J Erkwoh A Sabel MC | 2004 | Brain Pathol2004，14，2： | 1 |
| 6 | Glioblastoma multiforme at the site of metal splinter injury:a coincidence? Case report 显示文摘 | Sabel M Felsberg J Messing-Junger M | 1999 | J Neurosurg1999，91，6： | 1 |
| 7 | Efficient tumour formation by single human melanoma cells 显示文摘 | Quintana E Shackleton M Sabel MS | 2008 | Nature2008，456，7222： | 1 |
| 8 | Incidence and clinical presentation of primary hemophagocytic lymphohistiocytosis in Sweden显示文摘 | Meeths M Horne A Sabel M | 2015 | Pediatr Blood Cancer2015，62，2： | 1 |
| 9 | Sentinel node biopsy prior to neoadjuvant chemotherapy显示文摘 | Sabel MS Schott AF Kleer CG | 2003 | Am J Surg2003，186，2： | 1 |
| 10 | Immunologic response to cryoablation of breast cancer 显示文摘 | Sabel MS Nehs MA Su G | 2005 | Breast Cancer Res Treat2005，90，1： | 1 |
| 11 | Sentinel node biopsy prior to neoadjuvant chemotherapy 显示文摘 | Sabel M S Schott A F Kleer C G | 2003 | Am J Surg2003，186，2： | 1 |
| 12 | Long term follow-up of 15 patients with arrhythmogenic right ventricular dysplasia显示文摘 | Blomstrm-Lundqvist C Sabel CG Olsson SBA | 1987 | Br Heart J1987，58，8： | 1 |
| 13 | Vision restoration after brain and retina damage : the residual vision activation theory 显示文摘 | Sabel BA Henrich-Noack P Fedorov A | 2011 | Prog Brain Res2011，192，： | 1 |
| 14 | The use of local agents : surgicel and surgifoam 显示文摘 | Sabel M Stummer W | 2004 | European Spine Journal2004，，： | 1 |
| 15 | Building New Forms of- Cooperationina Volatile Economy 显示文摘 | SABEL C F STUDIED TRUST | 1993 | Human Relations1993，46，9： | 1 |
| 16 | Palaeoenvironment of the Eocene Eckfeld Maar lake (Germany):implications from geochemical analysis of the oil shale sequence显示文摘 | SABEL M BECHTEL A PüTTMANN W | 2005 | Organic Geochemistry2005，36，： | 1 |
| 17 | Surgical therapy of cu- taneous melanoma显示文摘 | Blazer D G 3rd Sondak V K Sabel M S | 2007 | Semin Oncol2007，34，3： | 1 |
| 18 | Rate of freeze alters the immuno- logic response after cryoablation of breast cancer 显示文摘 | Sabel MS Su G Griffith KA | 2010 | Annals of Surgi- cal Oncology2010，123，11： | 1 |
| 19 | Pragmatic Collaborations:Advancing Knowledge While Controlling Opportunism显示文摘 | HELPER S MACDUFFIE J P SABEL C | 2000 | Industrial and Corporate Change2000，9，3： | 1 |
| 20 | Wikirep: Digital reputationin virtual communities 显示文摘 | Sabel M Garg A Battii R | 2005 | Proceedings of XLIII CongressAnnuale Aica2005，，： | 1 |
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