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| 1 | Pressure balance and imbalance in the optic nerve chamber: The Beijing Intracranial and Intraocular Pressure (iCOP) Study显示文摘To determine the interdependence of intracranial pressure(ICP) and intraocular pressure(IOP) and how it affects optic nerve pressures, eight normal dogs were examined using pressure-sensing probes implanted into the left ventricle, lumbar cistern, optic nerve subarachnoid space in the left eye, and anterior chamber in the left eye. This allowed ICP, lumbar cistern pressure(LCP), optic nerve subarachnoid space pressure(ONSP) and IOP to be simultaneously recorded. After establishing baseline pressure levels, pressure changes that resulted from lowering ICP(via shunting cerebrospinal fluid(CSF) from the ventricle) were recorded. At baseline, all examined pressures were different(ICP>LCP>ONSP), but correlated(P<0.001). As ICP was lowered during CSF shunting, IOP also dropped in a parallel time course so that the trans-lamina cribrosa gradient(TLPG) remained stable(ICP-IOP dependent zone). However, once ICP fell below a critical breakpoint, ICP and IOP became uncoupled and TLPG changed as ICP declined(ICP-IOP independent zone). The optic nerve pressure gradient(ONPG) and trans-optic nerve pressure gradient(TOPG) increased linearly as ICP decreased through both the ICP-IOP dependent and independent zones. We conclude that ICP and IOP are coupled in a specific pressure range, but when ICP drops below a critical point, IOP and ICP become uncoupled and TLPG increases. When ICP drops, a rise in the ONPG and TOPG creates more pressure and reduces CSF flow around the optic nerve. This change may play a role in the development and progression of various ophthalmic and neurological diseases, including glaucoma. | Ruowu Hou Zheng Zhang Diya Yang Huaizhou Wang Weiwei Chen Zhen Li Jinghong Sang Sumeng Liu Yiwen Cao Xiaobin Xie Ruojing Ren Yazhuo Zhang Bernhard A. Sabel Ningli Wang | 2016 | Science China(Life Sciences)2016，59，5： | 11 |
| 2 | Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS显示文摘The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is lacking.To address this gap,we conducted a study aiming to investigate this association and identify relevant biomarkers.We analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune microenvironment.Additionally,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)populations.We employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune cells.Our findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal tissues.Moreover,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA replication.In conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets. | Sumeng Wang Silu Chen Huiqin Li Shuai Ben Tingyu Zhao Rui Zheng Meilin Wang Dongying Gu Lingxiang Liu | 2024 | The Journal of Biomedical Research2024，38，1： | 0 |
| 3 | Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage显示文摘Rabbit right eyes were injected with 3 or 6mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1,2, and 4 weeks after injection. There was no difference between left (control) and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe. | Sumeng Liu Wu Liu Yaling Ma Kegao Liu Meizi Wang | 2012 | Neural Regeneration Research2012，7，35： | 0 |
| 4 | Mechanically robust antireflective coatings显示文摘机械力量是影响并且限制 antireflective (AR ) 的一生表演的一个必要参数在光设备的涂层。明确地,当他们更加扩大基本应用的范围,有减少的反射的 amphiphobic AR 涂层意义大。此处,我们与减少的反射和提高的机械跳回描述 amphiphobic AR 涂层的设计和制造。介绍在经由蒸汽免职方法的 bilayer SiO 2 涂层上的层高度使它成为的薄 polytetrafluoroethylene (PTFE ) 液体驱虫剂。我们完成了减少的反射(<1%) 在全部可见波长范围,以及 tunability 上根据需要的波长区域。制作电影显示出更好热的稳定性(多达 300 琠敨朠潲楷杮椠普畬湥散漠 ? 桴 ? 湩整湲瑥愠摮琠' 虦 K 杯 ? 湩猠' 覕?敭楤慣? 敲敳牡档挠湡戠 ? 湥慨据摥戠 ? 牣睯獤畯 ' 詼?湡 ? 湯楬敮瀠瑡敩瑮瀠牯慴獬吗?? | Sadaf Bashir Khan Hui Wu Xiaochen Huai Sumeng Zou Yuehua Liu Zhengjun Zhang | 2018 | Nano Research2018，11，3： | 0 |
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