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| 1 | Staging of portal hypertension and portosystemic shunts using dynamic nuclear medicine investigations显示文摘AIM: To explore portal hypertension and portosys-temic shunts and to stage chronic liver disease (CLD) based on the pathophysiology of portal hemodynam-ics. METHODS: Per-rectal portal scintigraphy (PRPS) was performed on 312 patients with CLD and liver angio-scintigraphy (LAS) on 231 of them. The control group included 25 healthy subjects. We developed a new model of PRPS interpretation by introducing two new parameters,the liver transit time (LTT) and the circu-lation time between right heart and liver (RHLT). LTT for each lobe was used to evaluate the early portal hypertension. RHLT is useful in cirrhosis to detect liver areas missing portal in? ow. We calculated the classical per-rectal portal shunt index (PRSI) at PRPS and the hepatic perfusion index (HPI) at LAS. RESULTS: The normal LTT value was 24 ± 1 s. Abnor-mal LTT had PPV = 100% for CLD. Twenty-seven non-cirrhotic patients had LTT increased up to 35 s (median 27 s). RHLT (42 ± 1 s) was not related to liver disease. Cirrhosis could be excluded in all patients with PRSI < 5% (P < 0.01). PRSI > 30% had PPV = 100% for cirrhosis. Based on PRPS and LAS we propose the clas-sifi cation of CLD in 5 hemodynamic stages. Stage 0 is normal (LTT = 24 s,PRSI < 5%). In stage 1,LTT is increased,while PRSI remains normal. In stage 2,LTT is decreased between 16 s and 23 s,whereas PRSI is increased between 5% and 10%. In stage 3,PRSI is increased to 10%-30%,and LTT becomes undetect-able by PRPS due to the portosystemic shunts. Stage 4 includes the patients with PRSI > 30%. RHLT and HPI were used to subtype stage 4. In our study stage 0 had NPV = 100% for CLD,stage 1 had PPV = 100% for non-cirrhotic CLD,stages 2 and 3 represented the transition from chronic hepatitis to cirrhosis,stage 4 had PPV = 100% for cirrhosis. CONCLUSION: LTT allows the detection of early por-tal hypertension and of opening of transhepatic shunts. PRSI is useful in CLD with extrahepatic portosystemic shunts. Our hemodynamic model stages the evolution of portal hypertension and portosystemic shunts. It may be of use in the selection of patients for interferon therapy. | Mircea Dragoteanu Ioan A Balea Liliana A Dina Cecilia D Piglesan Ioana Grigorescu Stefan Tamas Sabin O Cotul | 2008 | World Journal of Gastroenterology2008，14，24： | 7 |
| 2 | Impaired expression of peroxisome proliferator-activated receptor γ in ulcerative colitis显示文摘 | Laurent Dubuquoy Emmelie ? Jansson Samir Deeb Sabine Rakotobe Mehdi Karoui Jean-Frédéric Colombel Johan Auwerx Sven Pettersson Pierre Desreumaux | 2003 | Gastroenterology2003，，5： | 2 |
| 3 | Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi‐targeted kinase inhibitors in pimasertib‐resistant human lung and colorectal cancer cells显示文摘 | Erika Martinelli Teresa Troiani Elena D’Aiuto Floriana Morgillo Donata Vitagliano Anna Capasso Sarah Costantino Loreta Pia Ciuffreda Francesco Merolla Loredana Vecchione Veerle Vriendt Sabine Tejpar Anna Nappi Vincenzo Sforza Giulia Martini Liberato Berri | 2013 | Int J Cancer2013，，9： | 2 |
| 4 | Stereotactic body radiation therapy in patients with hepatocellular carcinoma: A mini-review显示文摘Stereotactic body radiation therapy(SBRT) is an emerging treatment for hepatocellular carcinoma. This technique results in excellent local control rates with favorable toxicity profile despite being predominantly used in heavily pretreated patients or those unsuitable for other local therapies. SBRT may be used as a sole treatment or in combination with other local therapies as well as a bridging strategy for patient awaiting liver transplants. This brief review describes current practice of SBRT with respect to radiation technique, patient selection and treatment concepts. It summarizes available evidence from retroand prospective studies evaluating SBRT alone, SBRT in combination with other treatments and SBRT compared to other local treatment approaches. | Sabine Gerum Alexandra D Jensen Falk Roeder | 2019 | World Journal of Gastrointestinal Oncology2019，11，5： | 2 |
| 5 | Behavior of recursive division suriace near extraordinary points 显示文摘 | Doo D Sabin M | 1978 | Computer-Aided Design1978，10，6： | 1 |
| 6 | Valacyclovir provides optimum acyclovir exposure for prevention of cytomegalovirus and related outcomes after organ transplantation显示文摘 | Fiddian P Sabin C A Griffiths P D | 2002 | J Infect Dis2002，186，1： | 1 |
| 7 | Annular gas flow theory and prevention methods described显示文摘 | SUTTON D L FAUL R SABINS F | 1984 | Oil and Gas Journal1984，10，82： | 1 |
| 8 | Product configuration frameworks-A survey显示文摘 | Sabin D Weigel R | 1998 | IEEE Intelligent Systems & Their Applications1998，13，4： | 1 |
| 9 | A comprehensive genetic map of the human genome based on 5264 microsatellites显示文摘 | Collete D Sabine F ceclle F | 1996 | Nature1996，380，14： | 1 |
| 10 | Product Configuration Frameworks:A Survey显示文摘 | Sabin D Weigel R | 1998 | IEEE Intelligent Systems1998，13，4： | 1 |
| 11 | A random ized contro lledtrial of medicaltherapy versus endo scop ic ligation for the prevention of variceal rebleeding in patientsw ith cirrhosis显示文摘 | Patch D Sabin CA Goulls J | 2002 | Gastroenterology2002，123，4： | 1 |
| 12 | Behavior of recursive division surfaces near extraordinary points显示文摘 | DOO D SABIN M | 1978 | Computer-Aided Design1978，10，6： | 1 |
| 13 | Particle-mediated gene therapy of wounds显示文摘 | Jeffrey M D Thomas K Sabine A E | 2002 | Wound Rep and Reg2002，8，6： | 1 |
| 14 | A comprehensive genetic map of the human genome based on 5264 microsatellites 显示文摘 | Collete D Sabine F ceclle F | 1996 | Nature1996，380，14： | 1 |
| 15 | Saturated fatty acids induce insulin resistance in human podocytes : implications for dia- betic nephropathy显示文摘 | LENNON R PONS D SABIN M A | 2009 | Nephrol Dial Transplant2009，24，11： | 1 |
| 16 | Product configuration frameworks-A survey 显示文摘 | SABIN D WEIGEL R | 1998 | IEEE Intelligent Systemsd &Their Applications1998，13，4： | 1 |
| 17 | Long term probability of detection of HIV-1 drug resistance after starting antiretroviral therapy in routine clinical practice显示文摘 | Phillips AN Dunn D Sabin C | | 0，，05： | 1 |
| 18 | A comprehensive genetic map of the human genome based on 5264 microsatellites显示文摘 | Collete D Sabine F ceclle F | 1996 | Nature1996，380，14： | 1 |
| 19 | N - terminal sequ- ence and distal histidine residues are responsible for pH - regulated cytoplasmicm embrane binding of human AMP deaminase isoform E 显示文摘 | MAHNKE - ZIZELMAN D K SABINAL R L | 2002 | J Biol Chem2002，277，42： | 1 |
| 20 | Behavior of recursive division surfaces near extraordinary points显示文摘 | DOO D SABIN M | 1978 | Computer-Aided Design1978，10，6： | 1 |
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