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| 1 | Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin显示文摘The interplay between keratinocytes and immune cells,especially T cells,plays an important role in the pathogenesis of chronic inflammatory skin diseases.During psoriasis,keratinocytes attract T cells by releasing chemokines,while skin-infiltrating selfreactive T cells secrete proinflammatory cytokines,e.g.,IFN γand IL-17A,that cause epidermal hyperplasia.Similarly,in chronic graftversus-host disease,allogenic IFN γ-producing Th1/Tc1 and IL-17-producing Th17/Tc17 cells are recruited by keratinocyte-derived chemokines and accumulate in the skin.However,whether keratinocytes act as nonprofessional antigen-presenting cells to directly activate naive human T cells in the epidermis remains unknown.Here,we demonstrate that under proinflammatory conditions,primary human keratinocytes indeed activate naive human T cells.This activation required cell contact and costimulatory signaling via CD58/CD2 and CD54/LFA-1.Naive T cells costimulated by keratinocytes selectively differentiated into Th1 and Th17 cells.In particular,keratinocyte-initiated Th1 differentiation was dependent on costimulation through CD58/CD2.The latter molecule initiated STAT1 signaling and IFN γproduction in T cells.Costimulation of T cells by keratinocytes resulting in Th1 and Th17 differentiation represents a new explanation for the local enrichment of Th1 and Th17 cells in the skin of patients with a chronic inflammatory skin disease.Consequently,local interference with T cell–keratinocyte interactions may represent a novel strategy for the treatment of Th1 and Th17 cell-driven skin diseases. | Christian Orlik Daniel Deibel Johanna Küblbeck Emre Balta Sabina Ganskih Jüri Habicht Beate Niesler Jutta Schröder-Braunstein Knut Schäkel Guido Wabnitz Yvonne Samstag | 2020 | Cellular & Molecular Immunology2020，17，4： | 4 |
| 2 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | Mathews D H Sabina J Zuker M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 3 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D H SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 4 | Incidental gall bladder carcinoma in laparoscopic cholecystectomy: a report of 6 cases and a re- view of the literature显示文摘 | Sujata J SR Sabina K | 2013 | J Clin Diagn Res2013，7，1： | 1 |
| 5 | Rapid estimation of rate constant susing on-line SW-NIR and trilinear models显示文摘 | Sabina Bijlsma D J Louwerse(Ad) Willem Wimdig | 1998 | Analytical ChemicalActa1998，376，： | 1 |
| 6 | The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer显示文摘 | Edgard Graner Dan Tang Sabrina Rossi Antonella Baron Toshiro Migita Lisa J Weinstein Mirna Lechpammer Dieter Huesken Johann Zimmermann Sabina Signoretti Massimo Loda | 2004 | Cancer Cell2004，，3： | 1 |
| 7 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure 显示文摘 | Mathews DH Sabina J Zuker M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 8 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D H SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 9 | Expanded se-quence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，5： | 1 |
| 10 | Maximum and comparison principles for operators involving the p-Laplacian显示文摘 | Garcla-Melidn J Sabina de Lis J | 1998 | J MathAnal Appl1998，218，： | 1 |
| 11 | Incidental gall bladder carcinoma in laparoscopic cholecystectomy:a report of 6 cases and a review of the literature显示文摘 | Sujata J Sabina K | 2013 | J Clin Diagn Res2013，7，1： | 1 |
| 12 | Adenine nucleotide pool perturbation is a metabolic trigger for AMP deami- nase inhibitor-based herbicide toxicity显示文摘 | Sabina R L Paul A L Ferl R J | 2007 | Plant Physiol2007，143，4： | 1 |
| 13 | Self-consistent analysis of waves in a matrix-inclusion composite-A matrix containing cracks显示文摘 | SMYSHLYAVE V P WILLIS J R SABINA F J | | 0，，03： | 1 |
| 14 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D H SABINA J ZUKER M | 1999 | J Mol Biol1999，288，： | 1 |
| 15 | Expanded sequence dependence of thermodyn amic parameters provides robust prediction of RNA secondary structure显示文摘 | Mathews DH Sabina J Zuker M | | 0，，： | 1 |
| 16 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure显示文摘 | MATHEWS D H SABINA J ZUKER M | 1999 | Journal of Molecular Biology1999，288，： | 1 |
| 17 | Incidental gall bladder carcinoma in laparoscopic cholecystectomy : a report of 6 cases and a review of the literal'are 显示文摘 | Sujata J SR Sabina K | 2013 | J Clin Diagn Res2013，7，1： | 1 |
| 18 | Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure 显示文摘 | Mathews DH Sabina J Zuker M | 1999 | J Mol Biol1999，288，5： | 1 |
| 19 | On the global structure of the set of positive solutions of some semilinear elliptic boundary value problems显示文摘 | Fraile J M L6pez-G6mez J Sabina De Lis J C | 1995 | Journal of Differential Equations1995，123，1： | 1 |
| 20 | A Local Bifurcation Theorem for Degenerate Elliptic Equations with Radial Symmetry 显示文摘 | Garcia-Melian J Sabina Lis J de | 2002 | J Differ Equations2002，179，1： | 1 |
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