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| 1 | 接受纤溶治疗的ST段抬高心肌梗死患者在经皮冠状动脉介入治疗前服用氯吡格雷的效果:PCI-CLARITY研究显示文摘背景:关于经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)前氯吡格雷预治疗的益处目前仍有争议,并且其使用亦未获得普遍认可。
目的:于新近发生ST段抬高心肌梗死(ST—segment elevation myocardial infarction,STEMI)的患者中确定PCI前氯吡格雷预治疗预防严重不良心血管事件的效果是否优于PCI时开始采用氯吡格雷治疗。
设计、地点及参试者:CLARITY(PCI—Clopidogrel as Adjunctive Reperfusion Therapy)研究是一项于1863例患者中进行的前瞻性计划分析。这些患者均于CLARITY—TIMI(Thrombolysis in Myocardial Infarction)28试验中在血管造影后实施了PCI。CLARITY—TIMI28是一项在接受纤溶治疗的患者中进行的有关氯吡格雷效果的随机、双盲、安慰剂对照试验。患者于2003年2月至2004年10月入选自23个国家的319家医院。
干预:患者服用阿斯匹林并于纤溶治疗时开始随机接受氯吡格雷(300mg负荷剂量,以后75mg,每日1次)或安慰剂,直至冠状动脉造影前为止。造影在开始研究药物后2~8天进行。接受冠脉支架的患者建议于诊断性血管造影后给予开标氯吡格雷(包括负荷剂量)。
主要观测指标:一级终点为PCI至随机分组后30天心血管死亡、MI复发或脑卒中的复合发生率。二级终点包括在PCI之前发生的MI或脑卒中以及前述随机分组后30天相关终点。
结果:氯吡格雷预治疗可显著降低PCI后心血管死亡、MI或脑卒中的发生率(34[3.6%]比58[6.2%];校正优势比[odds ratio,OR],0.54[95%CI,0.35—0.85];P=0.008)。氯吡格雷预治疗还可降低PCI前MI或脑卒中的发生率(37[4.0%]比58[6.2%];OR,0.62[95%CI,0.40~0.95];P=0.03)。总体上,氯吡格雷预治疗可导致随机分组后30天心血管死亡、MI或脑卒中显著下降(70[7.5%]比112[12.0%];校正OR,0.59[95%CI,0.43~0.81];P=0.001;所需治疗例数=23)。TIMI严重或轻微出血的发生率未显著增加((18[20%]比17[1.9%];P〉0.99)。
结论:氯吡格雷预治疗可显著降低PCI前后心血管死亡或缺血并发症,而严重或轻微出血无显著增加。这些数据为STEMI患者早期使用氯吡格雷以及接受PCI的患者常规采用氯吡格雷预治疗方案提供了进一步的支持。 | Marc S. Sabatine Christopher P.Cannon C. Michael Gibson Jose L Lopez-Sendon Gilles Montalescot Pierre Theroux Basil S. Lewis Sabina A. Murphy Carolyn H. McCabe Eugene Braunwald 李呈亿(译) | 2006 | 美国医学会杂志(中文版)2006，25，4： | 2 |
| 2 | Localization of N-terminal sequences in human AMP deaminase isoforms that influence con- tractile protein binding显示文摘 | Mahnke-Zizelman D K Sabina R L | 2001 | Biochemical and Biophysical Research Communications2001，285，2： | 1 |
| 3 | N-terminal sequence and distal histidine residues are responsible for pH-regulated cyto- plasmic membrane binding of human AMP deaminase isoform E 显示文摘 | Mahnke-Zizelman D K Sabina R L | 2002 | Journal of Biological Chemistry2002，277，42： | 1 |
| 4 | 6-Shogaol inhibits monosodium urate crystal-induced inflammation- an in vivo and in vitro study 显示文摘 | Sabina E P Rasool M Mathew L | 2010 | Food Chem Toxicol2010，48，1： | 1 |
| 5 | Electrode materials for ionic liquid-based supercapacitors显示文摘 | Catia A Sabina B Mariachiara L | 2007 | J Power Sources2007，174，： | 1 |
| 6 | Aspects of meat quality: trace elements and B vitamins in raw and cooked meats 显示文摘 | Ginevra LB Sabina L Altero A | 2005 | Journal of Food Composition and Analysis2005，18，： | 1 |
| 7 | New evaluation for annular gas flow potential 显示文摘 | Sutton D Sabina L | 1984 | Oil Gas Journal1984，82，51： | 1 |
| 8 | Mycoplasma genitalium among women with nongonococcal nonchlamydial pelvic inflammatory disease 显示文摘 | Catherine L H Patricia A T 3 Sabina GA | 2006 | Infectious Diseases in Obstetrics and Gynecology2006，30，184： | 1 |
| 9 | Effectiveness of electrolyzed acidic water in killing Escherichia coli O157: H7, Salmonella Enteritidis, and Listeria monocytogenes on the surfaces of tomatoes显示文摘 | Bari M L Sabina Y Isobe S | 2003 | Journal of Food Protection2003，66，： | 1 |
| 10 | Effectiveness of electrolyzed acidic water in killing Escherichia coli O157 : H7,Salmonella Enteritidis, and Listeria monocytogenes on the surfaces of tomatoes显示文摘 | Bari M L Sabina Y Isobe S | 2003 | Journal of Food Protection2003，66，4： | 1 |
| 11 | Identification of a noncatalytic domain in AMP deaminase that influences binding to myosin显示文摘 | MARQUETANT R SABINA R L HOLMES E W | 1989 | Biochemistry1989，28，： | 1 |
| 12 | Adenine nucleotide pool perturbation is a metabolic trigger for AMP deami- nase inhibitor-based herbicide toxicity显示文摘 | Sabina R L Paul A L Ferl R J | 2007 | Plant Physiol2007，143，4： | 1 |
| 13 | Characterisation of composite edible films based on wheat starch and whey-protein isolate 显示文摘 | Ewelina B Sabina G Andrzej L | 2015 | International Journal of Food Science and Technology2015，50，： | 1 |
| 14 | AMP deaminase deficiency is associated with lower sprint cycling performance in healthy subjects显示文摘 | Fischer H Eshjornsson M Sabina R L | 2007 | J Appl Physiol2007，103，： | 1 |
| 15 | Regulation of skele tal muscle ATP catabolism by AMPD1 genotype during sprint exercise in asymptomatic subjects显示文摘 | NORMAN B SABINA R L JANSSON E | 2001 | J Appl Physiol2001，91，1： | 1 |
| 16 | 6-Shogao1 inhibits monosodium urate crystal-induced inflammation1 an in vivo and in vitro study 显示文摘 | Sabina E P Rasool M Mathew L | 2010 | Food Chem Toxicol2010，48，1： | 1 |
| 17 | Cortisol and Cortisone in Human Follicular Fluid and Serum and The Outcome of IVF Treatment显示文摘 | SABINA L CORNELIA V H UTE H | 2003 | Human Reproduction2003，18，： | 1 |
| 18 | N-terminal sequence and distal histidine residues are responsible for pH-regulated cytoplasmic membrane binding of human AMP deaminase isoform显示文摘 | MAHNKE-ZIZELMAN D K SABINA R L | 2002 | Journal of Biological Chemistry2002，277，42： | 1 |
| 19 | High-glucosetriggered apoptosis in cultured endothelial cells 显示文摘 | Sabina M Baumgartner-Parzer SM Wagner L | 1995 | Diabetes1995，44，11： | 1 |
| 20 | The Viable but noneulturable state and starvation are different stress responses of Enterococcus faecalis, as determined by proteome analysis 显示文摘 | SABINA H MARIA M L | 2002 | Journal of Bacteriology2002，12，2： | 1 |
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